@ThalerLab

Neuroimmunologist, clinician scientist investigating the immunobiology of autoimmune encephalitis

Joined June 2022
  • Tweets13
  • Following83
  • Followers66
Via @GreenJournal: Researchers have found Class IV evidence of an association between rituximab and a lower hazard to relapse in patients with autoimmune encephalitis: bit.ly/3QcevkB #NeuroTwitter @AANMember
A person sits in a blue chair and receives an infusion of medicine.

ALT A person sits in a blue chair and receives an infusion of medicine.

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Franziska Thaler retweeted
Carsten Finke@carstenfinke12 May 2023
In NMDA receptor #encephalitis, patients with persistent CSF NMDAR-Abs at 12 months were more likely to have subsequent relapses and a poor long-term outcome
French Reference Center for PNS and AE@LyonPNS_AE12 May 2023
Stop scrolling, here is our new article regarding Prognostic Value of Persistent CSF Antibodies at 12 Months in Anti-NMDAR Encephalitis pubmed.ncbi.nlm.nih.gov/3714… @lundahl1 @Vogrig_Alberto @maccuve @GnclvsDavid #autoimmune #encephalitis #antinmdar

Prognostic Value of Persistent CSF Antibodies at 12 Months in Anti-NMDAR Encephalitis - PubMed

In this study, patients with persistent CSF NMDAR-Abs at 12 months were more likely to have subsequent relapses and a poor long-term outcome. However, these findings should be interpreted with...

pubmed.ncbi.nlm.nih.gov
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Don’t miss this excellent updated review: “Autoimmune encephalitis: recent clinical and biological advances” ⁦@ANG_Oxford⁩ link.springer.com/article/10…

Autoimmune encephalitis: recent clinical and biological advances

Journal of Neurology - In 2015, we wrote a review in The Journal of Neurology summarizing the field of autoantibody-associated neurological diseases. Now, in 2023, we present an update of the...

link.springer.com
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Brain@Brain187828 Apr 2023
Cytotoxic T cells and plasma cells dominate early in temporal lobe epilepsy with GAD antibodies. New scientific commentary by Franziska Thaler & Edgar Meinl bit.ly/40NP9M6
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Brain@Brain187812 Apr 2023
Steinke et al. develop and validate a construct that neutralizes autoantibodies from patients with NMDAR encephalitis, and prevents receptor internalization and memory deficits in a mouse model. bit.ly/3Z2vgQi
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Adrian Budhram@adrianbudhram16 Apr 2023
Thanks @AAN @GreenJournal N2 for publishing our experience using prolonged corticosteroids for anti-LGI1 encephalitis. Examining the impact of acute immunotherapy regimen on need for maintenance immunotherapy may help optimize our treatment approach. nn.neurology.org/content/10/…

Prolonged Corticosteroids Without Maintenance Immunotherapy for Treatment of Anti-LGI1 Encephalitis...

ObjectivesTo analyze outcomes and relapse rate of patients with anti-LGI1 encephalitis referred to the London Health Sciences Centre Autoimmune Neurology Clinic, where prolonged (≥3 months) cortico...

neurology.org
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KawakamiLab@KawakamiLab22 Mar 2023
Congratulations to @LabMader on their new publication! 🥳It was a pleasure to contribute. Take a look at the pathomechanisms of MOG-antibody-associated disease: pnas.org/doi/10.1073/pnas.23…
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Brain@Brain187824 Feb 2023
In a large cohort of patients with anti-IgLON5 disease, Grüter et al. reveal early inflammatory CSF changes, and association of HLA-DRB1*10:01 with higher autoantibody titre, consistent with a primary autoimmune nature of the disease. bit.ly/3kqYn1B
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Study data support the hypothesis that the accumulation of GAD65-specific B cells and plasma cells in the CSF is an important feature of early disease stages of GAD65-Ab spectrum disorders, such as stiff-person syndrome and cerebellar ataxia. Learn more: bit.ly/3Zokjtf
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What happened to #neurological #autoantibody detection rates around the pandemic? We compared 2019 Vs 2020, across the 5 commonest cell surface Abs, and only saw a fall in LGI1 rates. The drop was marked around March-June - the time of the UK lockdown. jamanetwork.com/journals/jam…

Changes in the Rate of Leucine-Rich Glioma-Inactivated 1 Seropositivity During the COVID-19 Lockdown

This case-control study investigates the positivity rates of the most prevalent neuroglial surface antibodies during the COVID-19 pandemic.

jamanetwork.com
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Franziska Thaler retweeted
MaderLab@LabMader27 Jan 2023
Check out our new manuscript. Many thanks for this great collaboration: @Samanth68485267, Eva Oswald, Hoi Kiu Wong, @AtayVural, Vuslat Yilmaz, Erdem Tüzün, Recai Türkoğlu, Tobias Straub, Ingrid Meinl, @ThalerLab, Tania Kümpfel @LabMeinl,@LabMader
Atay Vural@AtayVural27 Jan 2023
Happy to contribute to this exciting study that uncovers a novel mechanism of effect for ocrelizumab on the BAFF-APRIL system. Cheers to my colleagues Simone Mader and Edgar Meinl and other collaborators 🥂 nn.neurology.org/content/10/… @LabMeinl @LabMader

Ocrelizumab Treatment Modulates B-Cell Regulating Factors in Multiple Sclerosis | Neurology...

Background and ObjectivesAntibodies to CD20 efficiently reduce new relapses in multiple sclerosis (MS), and ocrelizumab has been shown to be effective also in primary progressive MS. Although...

neurology.org
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Brain@Brain187823 Nov 2022
Tröscher et al. show that in patients with GAD65 antibody-associated temporal lobe epilepsy, cytotoxic T cells attack and kill neurons and are responsible for the early neuronal loss. bit.ly/3hglZUH
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