So cool to see our recent paper on environmental chemicals affecting brain health on the cover of Nature Neuroscience! Congrats again to @ErinFCohn and the team. Special thanks to Ella Maru Studio @Ella_Maru for the artwork

Excited to share this excellent article by Teddy Amenabar @TeddyAmen in The Washingotn Post @washingtonpost. It provides a clear & balanced look at our recent discovery of a class of household chemicals that are harmful to the brain's myelinating cells. wapo.st/4dcYUL6

Proud to see work from our lab making its way to patients. I am hopeful that the investigational drug, ION356, being tested by Ionis will be found to be both safe & effective in people with Pelizaeus Merzbacher disease🙏 Link to our 2020 @Nature paper: nature.com/articles/s41586-0…

Thank you @EricTopol for highlighting our paper. An open access link to the full article is here: rdcu.be/dCpPr

Open access link to the full paper: rdcu.be/dCpPr

I am also grateful to our supporters, including the @NIH_NINDS, @mssociety, @HHMINEWS, @nyscf, sTF5 Care, and the Long, Walter, Peterson, Goodman, and Geller families.

Thank you to the entire team including Ben Clayton @bllclayton, Mayur Madhavan @MayurMadhavan, Kristin Lee, Sara Yacoub, Yuriy Fedorov, Marissa Scavuzzo @marissascavuzzo, at @CWRUSOM & Tim Shafer and Katie Paul Friedman at the U.S. Environmental Protection Agency.

Future studies need to identify clearer links between exposure to these chemicals and brain health. Some of these chemicals have useful roles in our homes, but we need to consider what level of exposure is considered safe for ourselves and our kids (and pets 🐕).

Our goal is not to raise alarm bells or suggest that we completely remove these chemicals from our homes.

We also linked high exposure levels of these chemicals to developmental challenges in children, underscoring the need for deeper understanding and action.

Laboratory experiments with cellular and human brain organoid models, alongside developmental studies in mice, demonstrated the specific vulnerability of oligodendrocytes to these chemicals.

Our team analyzed over 1,800 environmental chemicals, uncovering that quaternary ammonium compounds (found in personal care products and disinfectants) and organophosphate flame retardants (in electronics and furniture) are particularly harmful to oligodendrocytes.

Our research, published in @NatureNeuro, focuses on the impact of common environmental chemicals on oligodendrocytes. These cells are crucial for brain function, insulating nerve cells. Our findings point to environmental factors as potential contributors to neurological diseases

Common household chemicals pose a risk to the brain’s myelinating cells Thrilled to share groundbreaking findings from our latest study led by @ErinFCohn at @CWRUSOM's Institute for Glial Sciences, in collaboration with the U.S. @EPA. nature.com/articles/s41593-0…

Read the full scientific paper here 👇 rdcu.be/dy7in