@SynapticHolly

Neurobiologist | Postdoctoral Research Fellow @Neuromedicines @MIPS_DDB | PhD in synaptic physiology from @TheGordonLab @TheFlorey @UniMelb | Queer feminist 🌈

 Melbourne, Victoria
linkedin.com/in/holly-melland/
Joined December 2017
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  • Following382
  • Followers390
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Exciting news 🔊: I've recently started as a postdoctoral Research Fellow with @chrislangmead and @gdstewart82 at @MIPS_DDB and @Neuromedicines Discovery Centre, researching novel neurotherapeutics. 🧠💊🔬
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Beautiful work systematically deconvolving the calcium signals driving different modes of neurotransmitter release!
Camille Wang@camilleswang3 Oct 2023
I’m so excited to share that my paper is now online at Cell Reports! We use optical imaging to examine the spatial organization of presynaptic calcium signals. More details below 🧵👇 cell.com/cell-reports/fullte…

Spatially non-overlapping Ca2+ signals drive distinct forms of neurotransmission

Wang et al. use GCaMP8s-Syb2 to visualize three distinct Ca2+ signals within individual presynaptic boutons, and these are derived from unique Ca2+ sources. Using an optical approach employing...

cell.com
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Dr Holly Melland 🔬🧠 retweeted
The Gordon Lab@TheGordonLab30 Mar 2023
Absolutely brilliant PhD oration by @elyas_arvell. An exceptional scientist, a generous colleague, a fierce advocate, and a wonderful human; it's been an absolute gift to have been invited to come on this journey with them. They have helped make our lab @TheFlorey a special place
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Dr Holly Melland 🔬🧠 retweeted
Chris Langmead@chrislangmead8 Dec 2022
So happy to have the opportunity to bring our #MTDD lab and closest @Neuromedicines collaborators together at beautiful @HeideMoMA for a day of strategy and creative art.
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I'll very much miss @TheGordonLab and @TheFlorey, and am so grateful for my experiences with them, but I'm eager to start this new chapter and explore new science. Thank you @chrislangmead and @gdstewart82 for bringing me on board!
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Dr Holly Melland 🔬🧠 retweeted
Lignani Lab@LignaniLab_UCL3 Nov 2022
📢 Very happy to share our paper just published in @ScienceMagazine in collaboration with @Newrotrash and led by the fabulous @sophieqyc_q! Activity-dependent Gene Therapy for Neurological Diseases #epilepsy #genetherapy @UCLIoN @EpilepsyRUK @The_MRC science.org/doi/10.1126/scie…

On-demand cell-autonomous gene therapy for brain circuit disorders

Expressing a transgene that reduces neuronal excitability using an activity-dependent promoter stops seizures in mouse models of epilepsy.

science.org
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Dr Holly Melland 🔬🧠 retweeted
Adam Hines@AdamDHines2 Nov 2022
With submission looming ever closer, I'm now in the strange position to say I'm on the lookout in the job market! If you or someone you know is on the hunt for a dedicated & passionate post-doctoral researcher, please do not hesitate to get in touch adamdhines.com
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Dr Holly Melland 🔬🧠 retweeted
QueersInScience@QueersInScience17 Oct 2022
Catch up with QiS VIC over board games on Thursday Oct 27th! If you haven't been to a QiS event before, don't stress! We love meeting new people and we'll try not to be overly competitive😉 For more details & to let us know if you'll be there➡️ bit.ly/3D30j6T
Queers In Science VIC Board game night Join us for some old school board game fun! When: 6pm, Thursday 27th October Where: Fortress (Shop 25, 23 Caledonian lane, Melbourne, VIC 3000) Meet us in the tavern! Catch up with your QueersInScience friends, or make new ones, over some board games and fantasy-themed pub grub. We'll be meeting at 6pm on Thursday the 27th of October in The Tavern at Fortress Melbourne Emporium. You can access the venue either from the Lower Ground inside Emporium or from an external entrance at Shop 25/23 Caledonian Lane, Melbourne CBD. Fortress is a wheelchair-accessible venue that has all-gender toilet options. Feel free to check out Fortress's other tabletop, video, and arcade gaming facilities while you're there.

ALT Queers In Science VIC Board game night Join us for some old school board game fun! When: 6pm, Thursday 27th October Where: Fortress (Shop 25, 23 Caledonian lane, Melbourne, VIC 3000) Meet us in the tavern! Catch up with your QueersInScience friends, or make new ones, over some board games and fantasy-themed pub grub. We'll be meeting at 6pm on Thursday the 27th of October in The Tavern at Fortress Melbourne Emporium. You can access the venue either from the Lower Ground inside Emporium or from an external entrance at Shop 25/23 Caledonian Lane, Melbourne CBD. Fortress is a wheelchair-accessible venue that has all-gender toilet options. Feel free to check out Fortress's other tabletop, video, and arcade gaming facilities while you're there.

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Dr Holly Melland 🔬🧠 retweeted
Cortical Labs
@CorticalLabs12 Oct 2022
Meet DishBrain: human brain cells in a dish learn to play Pong. Our latest paper published today in @NeuroCellPress. Full paper at doi.org/10.1016/j.neuron.202….
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Dr Holly Melland 🔬🧠 retweeted
Konrad Platzer
@platzer_k22 Apr 2022
📢 New preprint 📢 We establish #STX1A as a novel #MorbidGene. Heterozygous and homozygous variants cause a neurodevelopmental disorder with or without epilepsy depending on variant type/location. A short 🧵... 👇 [1/9]
medRxiv@medrxivpreprint21 Apr 2022
Heterozygous and homozygous variants in STX1A cause a neurodevelopmental disorder with or without epilepsy medrxiv.org/cgi/content/shor… #medRxiv
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Dr Holly Melland 🔬🧠 retweeted
The Florey@TheFlorey17 Mar 2022
🔬Extensive scientific collaboration underpins research on #SYT1 gene variants causing rare #neurodevelopmental disorder, #BakerGordonSyndrome. 📖ow.ly/E2LE50IkloL @GIMJournal 👇 doi.org/10.1016/j.gim.2021.1… @TheGordonLab @SynapticHolly @KBGenesBrains @mrccbu #RareDisease
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Dr Holly Melland 🔬🧠 retweeted
Dr Holly Melland 🔬🧠@SynapticHolly28 Feb 2021
It is a privilege to play a small role in helping to achieve diagnoses, understanding, and better care for people with rare diseases. It takes a village, and we need to invest in the wellbeing of the not-so-rare 300 million people living with a rare disease. #RareDiseaseDay
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Dr Holly Melland 🔬🧠 retweeted
The Gordon Lab@TheGordonLab11 Feb 2022
It's been a rough week for queer folk in Australia, especially trans and non-binary folk, and today is International Day of Women and Girls in Science. I'm particularly proud of the fact that all the authors of this work are queer women or non-binary folk 🏳️‍🌈💪
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Dr Holly Melland 🔬🧠 retweeted
The Gordon Lab@TheGordonLab11 Feb 2022
Woo! We'll take it 🙌😄! Really proud of this beast of a review (written in a pandemic). @SynapticHolly and @asciencequeer worked incredibly hard to put together what we hope is a useful and timely resource for the field.
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Dr Holly Melland 🔬🧠 retweeted
Dr. Samantha Barton@samkbarton78 Feb 2022
We're hiring! If you've recently finished your PhD, are an iPSC wizard and are just generally a rad person then please apply! floreyinstitute.applynow.net…
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Proud to announce that our work identifying 10 new variants in SYT1 has now been published in Genetics in Medicine! @GIMJournal doi.org/10.1016/j.gim.2021.1…
Screenshot of article title page. Titled: "Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder" in the journal Genetics in Medicine published by Elsevier. Include full author list (first author Holly Melland, last author Kate Baker) and abstract.

ALT Screenshot of article title page. Titled: "Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder" in the journal Genetics in Medicine published by Elsevier. Include full author list (first author Holly Melland, last author Kate Baker) and abstract.

Figure from the article with two panels. Top panel showing a linear domain diagram of synaptotagmin-1 with the location of variants identified along the length of the protein. Bottom panel showing the three-dimensional structure of C2A and C2B domains of synaptotagmin-1 with amino acids affected by variants highlighted.

ALT Figure from the article with two panels. Top panel showing a linear domain diagram of synaptotagmin-1 with the location of variants identified along the length of the protein. Bottom panel showing the three-dimensional structure of C2A and C2B domains of synaptotagmin-1 with amino acids affected by variants highlighted.

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Although Baker-Gordon Syndrome is a #RareDisease, new variants of uncertain significance are regularly being identified. We hope this study increases confidence in diagnosing individuals with likely pathogenic SYT1 variants, providing much-needed answers for affected families.
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Thank you especially to @KBGenesBrains, @TheGordonLab, @amkolesnik, and twitterless Fabian Bumbak, as well as all the researchers, clinicians, geneticists, and importantly patients and families that were involved from across the globe. #SYT1 Connected.
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