Yapeng Su retweeted
Fred Hutch is bringing the 🔥 to #STATMadness!
@SuYapeng and team uncovered how the sugar mannose supercharges T cells and boosts tumor control.
Let’s run up the score — vote in @statnews’ bracket-style tournament now! 👉 bit.ly/4aUz4en
Yapeng Su retweeted
Two obstacles in #CancerImmunotherapy are tumor-infiltrating T cell exhaustion and mitochondrial dysfunction.
Drs. @SuYapeng & Philip Greenberg at @FredHutch & @UW identified the E3 ubiquitin ligase KLHL6 as a dual-negative regulator of both.
🔎 Abstract: go.nature.com/4qqLAsK
Yapeng Su retweeted
This @Nature study (rdcu.be/eY5hC) shows that loss of the ubiquitin ligase KLHL6 in Tex cells prevents TOX degradation, stabilizing exhaustion and mitochondrial dysfunction. Another case linking proteostasis to T cell exhaustion. Congrats to @HutchGreenberg, Guideng Li.
Yapeng Su retweeted
Nature research paper: The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction
go.nature.com/457rivW
🚨 Excited to share our collaborative work in @Nature ! 🚨
We identify KLHL6, an E3 ubiquitin ligase, as a key regulator that protects CD8⁺ T cells from both exhaustion and mitochondrial dysfunction — two major barriers in cancer immunotherapy. nature.com/articles/s41586-0…🧵👇
📌 Take-home message:
Targeting ubiquitin-mediated proteostasis can coordinate cell state and metabolism in T cells.
KLHL6 is a multifunctional, clinically actionable target for next-gen immunotherapy.
"Huge thanks to an amazing team, mentors, and collaborators at @fredhutch @FH_IRC and globally
📄 Nature: “The ubiquitin ligase KLHL6 drives resistance to CD8⁺ T cell dysfunction”
🔗 (nature.com/articles/s41586-0…)
Yapeng Su retweeted
The spark that led to a Nobel. Dr. Mary Brunkow on the mentors who changed everything.
“I wouldn't be standing here today if it weren't for a couple of really important mentors in my life who showed me what a life in research would look like.”
During her Nobel Prize lecture, medicine laureate Mary Brunkow spoke about the people that helped her during her scientific journey.
Watch her full lecture: youtube.com/watch?v=n1tfKu3e…
Yapeng Su retweeted
🚨 Breaking: ISB wins a 2025 #AWSImagineGrant!
The funding will supercharge Tarpon, our generative-AI platform that decodes T-cell receptors into digital immune fingerprints — a game-changer for immune-based therapies.
Read more ➤ isbscience.org/news/press-re…
@awscloud
Tonight at my former home, @ISBsci, I celebrated my former lab mate Mary Brunkow as this year’s Nobel Laureate, surrounded by mentors who believed in me and shaped my journey. 💛 Science is about people as much as discovery.
#ScienceFamily #Nobel #Gratitude #Mentorship
Yapeng Su retweeted
In the latest issue! Remembering David Baltimore (1938–2025) dlvr.it/TPKHDs
