The Immunotherapy Integrated Research Center accelerates discovery by promoting cross-disciplinary and cross-divisional collaboration @fredhutch.
Seattle, WA
Joined October 2019
- Tweets111
- Following95
- Followers125
- Likes40
Survival Outcomes in Chronic Lymphocytic Leukemia During the Novel Agent Era: A Population‐Based Analysis - Di - 2026 - Cancer Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/… @fredhutch
First-In-Human Study of 211At-CD45 Radioimmunotherapy With Nonmyeloablative Conditioning Hematopoietic Cell Transplantation for Adults With Hematologic Malignancies | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JCO…
@fredhutch
Strengthening Individual-Patient Treatment Prediction in Precision Oncology: The Case for a National Evidence Infrastructure | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JCO… @fredhutch
10x Genomics Announces New Collaboration to Advance Single Cell and Spatial Applications Across Solid Tumors and B... prn.to/47Fkl5X @fredhutch
Congrats to the IIRC Team for another great Thomas Symposium!
Reprogramming engineered autologous T cells to overcome resistance in patients with Merkel cell carcinoma | Science Translational Medicine science.org/doi/10.1126/scit…
@HutchInnovation @fredhutch
Fixed-treatment duration venetoclax following covalent BTKi progressio… sciencedirect.com/science/ar…
@fredhutch
Plant-based whole-food diets are feasible during auto-HCT and are associated with dose-dependent microbiome modulation ashpublications.org/bloodadv…
@fredhutch
Immunotherapy IRC @fredhutch retweeted
Fred Hutch is recruiting an open-rank faculty member in cancer immunotherapy. Join a leading immunotherapy research community and help advance next-generation treatments from discovery to clinical translation. Apply: apply.interfolio.com/188969
Uneven TCR chain pairing constraints govern epitope recognition | Science science.org/doi/10.1126/scie…
@fredhutch
JCI - B-cell depletion improves therapeutic index of combination checkpoint blockade in patients with advanced melanoma jci.org/articles/view/205606 @fredhutch
CD45-Directed Radioimmunotherapy with the Alpha-Emitter Astatine-211 As Conditioning for Autologous Hematopoietic Stem/Progenitor Cell Gene Therapy: Results from a Nonhuman Primate Model ashpublications.org/blood/ar… 1/2014/533073/CD45-Directed-Radioimmunotherapy-with-the-Alpha . @fredhutch
Researchers optimized a method to isolate nuclei from flash‑frozen mouse colon tissue for single‑nuclei RNA sequencing using Miltennyi’s lysis buffer and Octo-dissociator with chillers. The protocol improved nuclei RNA quality and counting prior to fixing nuclei for the 10x. FLEX- Multiplex protocol, supporting high‑quality, cost-effective molecular profiling when other single‑cell methods aren’t possible. @HutchInnovation bit.ly/4ueaNZi
Immunotherapy IRC @fredhutch retweeted
Autoantibodies cause autoimmune disease, shape infection outcomes, and alter cancer immunotherapy. But what role might they play in neuropsychiatric disease? In our new preprint, Katlyn Nemani and @JillianRJaycox take on this question in schizophrenia. 🧵
biorxiv.org/content/10.64898…
ALT https://www.biorxiv.org/content/10.64898/2026.05.04.722731v1
Immunotherapy IRC @fredhutch retweeted
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too?
That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below
nature.com/articles/s41586-0…
pubmed.ncbi.nlm.nih.gov/4198… In 4,258 patients, donor age affected outcomes differently depending on donor type. @fredhutch researchers & collaborators found while younger family donors showed rising risk once donors were ~38, matched unrelated donors stayed low‑risk until ~50 with better overall survival, allowing for more personalized donor choices.
