It is all about the structure...
Safed, Israel
Joined May 2019
- Tweets108
- Following129
- Followers119
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Moshe Dessau retweeted
Dr. Shai Bel has uncovered a surprising link between antibiotics and inflammatory bowel disease (IBD), a condition affecting about 1% of the world’s population.
His research, published in the journal Science Advances, reveals that antibiotics hinder the secretion of protective mucus enabling bacteria to penetrate deeper into the gut, leading to bacterial infiltration, systemic bacterial antigen replication, and ulcers - all hallmarks of IBD.
"This finding shatters the paradigm that antibiotics harm only bacteria and not our own cells," Dr. Bel explains. But Dr. Bel and his team are already planning their next steps. They aim to explore potential treatments that could mitigate the adverse effects of antibiotics on mucus secretion.
Link for the article: science.org/doi/10.1126/scia…
Picture below: Dr. Bel with his lab staff.
@Bar_ilan
@Mucus_Man
@MadaGadol
@ScienceAdvances
#IBD #INFLAMMATORYBOWELDISEASE
#research #medicine
#MedicalResearch
#facultyofmedicine
#biology
Moshe Dessau retweeted
This is a fantastic discovery 🤯
Super thrilled to share a preprint from the lab biorxiv.org/cgi/content/shor…
We found pH regulates the inflammatory response 🔥in #macrophage by controlling BRD4-dependent transcriptional condensates. In my lab led by @younggouu
Moshe Dessau retweeted
Prof. Omry Koren was chosen among the most cited scientists in academic journals, and has been recognized as such for the 6th consecutive year, according to a study conducted by Clarivate research and data processing company.
@KorenLab
Moshe Dessau retweeted
This is what humanitarian aid looks like. And the fact that it’s coming from IDF soldiers says it all.
Moshe Dessau retweeted
👀 What a fascinating journey from ancient trinkets to single nuclear pore complexes.
Find here ➡️bit.ly/3Q1lCer the ´In a Nutshell´ by ✍️ Boris Fichtman & Amnon Harel @biumedicine
#auxinInduced_degron #NPC #RanBP2_NUP358 #SEM
ALT A journey from the polished quartz lenses in the eyes of an ancient Egyptian statue of a seated scribe, through the development of microscopes and towards modern electron microscopy. Recent advances in field emission scanning electron microscopy have made it possible to expose nuclei from human cells and to focus on individual nuclear pore complexes, comparing their architectural features.
Moshe Dessau retweeted
2/3 We've discovered that the key lies in the enzyme SARM1, responsible for executing the degeneration process by depleting the vital molecule NAD. 😮 Surprisingly, the C. elegansSARM1 (a.k.a. TIR-1) is significantly less active compared to the human ortholog.
Moshe Dessau retweeted
1/3 🧠 Curious about why human neuronal axons degenerate after injury, while C. elegans axons remain intact? 🤔 Our new Cell Reports article in collaboration with hammarlab.org/ has the answer!
cell.com/cell-reports/fullte…
Moshe Dessau retweeted
3/3💡 This robust activity of human SARM1 is what drives the degenerative function. Fascinatingly, when we introduced human SARM1 into C. elegans axons, they experienced degeneration after injury too! 💥
Moshe Dessau retweeted
🚨 New paper alert 🚨
Our recent paper, led by the one and only Ayelet Peres has just been published in Nucleic Acids Research. It introduces new methods for germline V allele annotation & genotype inference.
[t.ly/YsoGo] 📄
🧵1/5
Moshe Dessau retweeted
Congratulations to Prof. Orly Avni on your first day as new Dean of the Azrieli Faculty of Medicine!
@Bar_ilan
Moshe Dessau retweeted
MDA5 is the primary innate immune sensor for many viruses & a disease mutation hotspot. Our preprint w/ @viropractor shows cooperative ATP hydrolysis allows MDA5 to bind RNA selectively & displace other proteins. Selectivity is tuned by LGP2 NTP hydrolysis doi.org/10.1101/2023.05.25.5…
Moshe Dessau retweeted
This paper is insane 🤯 for a few reasons. The first being they experimentally evolved a yeast into a multicellular organism. The second is that the review process took longer than the evolution process 🤦🏻♂️
nature.com/articles/s41586-0…
Moshe Dessau retweeted
Whoa.
"Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery".
tinyurl.com/tdwej75j
Moshe Dessau retweeted
Congratulations to the winners of our Scientific Challenge in Israel—Ron Piran & Lihi Grinberg from Bar-Ilan University. Ron & Lihi will work with both Visium Spatial Gene Expression & Chromium Single Cell Gene Expression to advance their #diabetes research. @ubarilan @PiranRon
Moshe Dessau retweeted
Congratulations to my (former) student Moshe Dessau @StructureRocks on getting tenure and getting promoted! Always expected great things from you. From here it just gets better!
Moshe Dessau retweeted
This 1.85 Å structure of tobacco mosaic virus, released today on #EMDB, is now the highest resolution #CryoEM structure resolved using #Helical reconstruction!
EMDB: ebi.ac.uk/emdb/EMD-16572
Moshe Dessau retweeted
A journey that started somewhere in 2014 in Burnham (today Sanford Burnham Prebys @sbpdiscovery) has finally ended at inflammation and Regeneration #InflammRegen:
Thank you, Gal Reches et al., for bringing this project to conclusi…lnkd.in/eegrTCAW lnkd.in/eGyVc7K4
Moshe Dessau retweeted
So excited that we finally have the ACTIVE NLRP3 inflammasome structure, thanks to super talented Le Xiao @LeXiao17, and Venkat Magupalli @MagupalliVenny! nature.com/articles/s41586-0… – at Boston, MA
Moshe Dessau retweeted
Our study on Atlas virus, an endogenous virus in hookworms, has just been published in @ScienceAdvances. Atlas has a retrovirus-like genome but contains a phlebovirus-like class II membrane fusion protein instead of the class I Env found in retroviruses. science.org/doi/10.1126/scia…
