@StephenRG97

https://nitter.cf/t.co/V7NQMy5Igq

Joined February 2012
  • Tweets468
  • Following417
  • Followers503
31Media
Really excited to share my first paper from the @JohnWhitneyIIDR lab, alongside an amazing grad student, Polina. We identify a chaperone family required for the folding of a domain of T7SS toxins, and solve the structure of the chaperone-toxin complex. pnas.org/doi/10.1073/pnas.25…

A widespread family of molecular chaperones promotes the intracellular stability of type VIIb...

To survive in highly competitive environments, bacteria use specialized secretion systems to deliver antibacterial toxins into neighboring cells, t...

pnas.org
5
18
865
Stephen Garrett retweeted
José R Penadés@jrpenades
2 Dec 2025
Excited to share our latest work with @AlbertoMarina14 and @AvigdorEldar labs, where we decipher the mechanism by which SPβ-like phages sense the SOS response to control the lysis–lysogeny switch. biorxiv.org/content/10.1101/…

An unprecedented DNA recognition–mimicry switch governs induction in arbitrium phages

Temperate phages integrate multiple information sources to regulate lysis-lysogeny transitions. SPBeta-like phages use arbitrium signalling and DNA damage to control repressor activity during lytic...

biorxiv.org
1
10
33
2,274
academic.oup.com/nargab/arti… Exciting to see a plethora of toxin/antitoxin systems (e.g., retrons, type II) identified in P. aeruginosa genomic islands with limited representation in DefenseFinder, etc.

Genomic islands in Pseudomonas encode modular hotspots of defence and anti-defence systems

Abstract. Bacteria use diverse defence systems to resist phage predation, many of which cluster within mobile genetic elements (MGEs) and defence islands.

academic.oup.com
2
31
2,012
Stephen Garrett retweeted
Giuseppina Mariano@GiusyM1990
1 Oct 2025
🚨PhD Opportunity Alert🚨 Join me,@DrSuzieHumphrey and Donal Wall to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa. Apply here: gla.ac.uk/postgraduate/docto…
1
3
249
Stephen Garrett retweeted
Tim Blower@BlowerLab
23 Jun 2025
Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol academic.oup.com/nar/article…

PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex...

Abstract. BREX (Bacteriophage Exclusion) systems, identified through shared identity with Pgl (Phage Growth Limitation) systems, are a widespread, highly d

academic.oup.com
7
27
1
83
6,425
New preprint from @MacBiochemGrad and @McMasterMDPhD student @JakeColautti and @BBS_McMasterU and @McMasterIIDR Postdoc @StephenRG97!
bioRxiv Microbiology@biorxiv_micrbio
14 Apr 2025
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria biorxiv.org/content/10.1101/… #biorxiv_micrbio

Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria

Many species of bacteria produce small-molecule antibiotics that enter and kill a wide range of competitor microbes. However, diffusible antibacterial proteins that share this broad-spectrum activity...

biorxiv.org
1
6
354
A broad-spectrum, contact-independent antimicrobial that is neither a nonribosomal peptide nor a BGC- assembled small molecule from @JakeColautti @StephenRG97 @JohnWhitneyIIDR
bioRxiv Microbiology@biorxiv_micrbio
14 Apr 2025
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria biorxiv.org/content/10.1101/… #biorxiv_micrbio

Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria

Many species of bacteria produce small-molecule antibiotics that enter and kill a wide range of competitor microbes. However, diffusible antibacterial proteins that share this broad-spectrum activity...

biorxiv.org
2
1
282
.@jrpenades (@imperialcollege) and colleagues published a new review on #phage satellite genetics, ecology and #evolution, diving into how these elements impact bacterial evolution and virulence. buff.ly/GTeAxVg
9
31
1,304
Some really cool work from @JakeColautti in the @JohnWhitneyIIDR lab on a family of contact-independent, broad spectrum protein toxins that target Gram-positive bacteria.
bioRxiv Microbiology@biorxiv_micrbio
14 Apr 2025
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria biorxiv.org/content/10.1101/… #biorxiv_micrbio

Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria

Many species of bacteria produce small-molecule antibiotics that enter and kill a wide range of competitor microbes. However, diffusible antibacterial proteins that share this broad-spectrum activity...

biorxiv.org
1
6
498
Stephen Garrett retweeted
Alexander Harms@AHarms485
8 Apr 2025
And here it is, the completed BASEL collection finally published as early access in @PLOSBiology - see the thread for more details. 🤗🧬🎣
Alexander Harms@AHarms485
6 Feb 2025
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
1
27
1
81
6,847
Stephen Garrett retweeted
Giuseppina Mariano@GiusyM1990
9 Mar 2025
Pleased to share that my main Sir Henry Wellcome Fellowship project is now published! This study provides mechanistic insights into Zorya II function. Grateful to all who contributed! Read it here:tinyurl.com/ZoryaII
2
15
90
3,896
We have extended the deadline for this! If you are passionate about phage-bacteria interactions, check this out and join us!
Giuseppina Mariano@GiusyM1990
24 Jan 2025
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
10
16
2,503
It’s not too late to apply for a postdoc position with Giusy in Glasgow! Super supportive lab doing some really exciting science!
Giuseppina Mariano@GiusyM1990
18 Feb 2025
Still time to apply! Join us in Glasgow—be part of my team. Closing date: Feb 24th
2
3
556
Nanopore sequencing-based measurement of paramyxovirus RNA editing reveals virus-specific differences in editing efficiency of mRNA, ... biorxiv.org/content/10.1101/… #biorxiv_micrbio

Nanopore sequencing-based measurement of paramyxovirus RNA editing reveals virus-specific differe...

Paramyxovirus polymerase recognizes an RNA editing signal on the viral genome and transcribes mRNA in which guanine nucleotides are inserted in a template-independent manner. This enables the...

biorxiv.org
2
3
742
Stephen Garrett retweeted
Tim Blower@BlowerLab
13 Feb 2025
The lab is now up and running at New England Biolabs @NEBiolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃 neb.wd5.myworkdayjobs.com/en…
6
48
3
149
19,569
Love phage-bacteria interactions, anti-phage systems, and a sprinkle of evolutionary biology? There’s still time to apply and join our team in Glasgow at @UofGSii !
Giuseppina Mariano@GiusyM1990
24 Jan 2025
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
1
15
1
33
3,729
Stephen Garrett retweeted
Luke Allsopp@luke_allsopp
3 Feb 2025
Latest out from the lab. Crazy amounts of #diversity in #T6SS #effectors #pseudomonas out now in @NatureComms @MPI_EvolBio @ImperialNHLI imperial.ac.uk/news/260613/b… evolbio.mpg.de/3804447/same-… nature.com/articles/s41467-0…

Bacterial survival, top marks for maths and a mystery solved: News from Imperial | Imperial News |...

From the crossbow-like tactics used by bacteria, to top marks for homework and a research mystery solved, here is some quick-read news from Imperial.

imperial.ac.uk
6
32
1,285
Stephen Garrett retweeted
Tim Blower@BlowerLab
24 Jan 2025
Super opportunity to join Giusy in Glasgow!
Giuseppina Mariano@GiusyM1990
24 Jan 2025
🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
8
15
3,036
Stephen Garrett retweeted
EMBO@EMBO
24 Jan 2025
EMBO Postdoctoral Fellowships support internationally mobile postdoctoral researchers in Europe and around the world. Apply here (next cut-off date is 14 February): embo.org/funding/fellowships… #ResearchFunding #LifeSciences

Fellowships, grants and career support – Postdoctoral Fellowships – EMBO

Supporting internationally mobile postdoctoral researchers in Europe and around the world

embo.org
146
8
319
49,452
The final version of our Serratia paper is now out! Congrats to @TomCX99 and (X-less) Suraj, and a big thank you to @BlowerLab and @StephenRG97. tinyurl.com/3vnyvufa

Multi-conflict islands are a widespread trend within Serratia spp.

Cummins, Songra et al. identify three Serratia defense islands co-localizing anti-phage systems, virulence factors, and anti-bacterial factors. These islands provide a resource for discovering...

cell.com
Giuseppina Mariano@GiusyM1990
29 Jan 2024
New pre-print from the lab, led from (for now Twitter-less) star-RA Tom Cummins. If you did receive his PhD application, you do not want to miss this chance, Tom is a star! As always, fun collaboration with the amazing @BlowerLab and @StephenRG97
4
13
1,773
Load more