Joined November 2014
- Tweets1.9K
- Following794
- Followers765
- Likes2K
2/ Use linked health + genomic data from @ukfuturehealth and @AllofUsResearch to study how comorbidities cluster, accumulate and causally relate to #psoriasis and #PsoriaticArthritis across diverse populations.
Steven Zhao retweeted
📢 We are delighted to share our newly-updated clinical guideline for the management of axial spondyloarthritis! Read more: bit.ly/3EdQnei
@NASSexercise
@BritspaUK
#guidelines #rheumatology #axSpA
Steven Zhao retweeted
📢Do you work in #Rheumatology or #Dermatology in the UK?
Please help us understand the impact of #obesity on #psoriasis and #PsoriaticArthritis
👉🏽app.onlinesurveys.jisc.ac.uk…
Steven Zhao retweeted
A great new resource for phenome-wide genetic explorations by the Estonian Biobank🇪🇪🧬
👉206,159 participants
👉GWASs for 4,884 ICD-10 diagnoses
👉2,127 unique GWAS loci
👉778 putatively novel locus-phenotype associations
Steven Zhao retweeted
A GWAS meta-analysis for sarcoidosis in 9,755 cases and 1,526,867 controls🧬
In diseases like sarcoidosis, where we know little about etiology, GWAS can be much more interesting, as they provide pathogenesis insights with potential for informing therapeutic strategies
Steven Zhao retweeted
#PhysicalActivity for those with chronic widespread pain & #fibromyalgia effective in
✅Reducing #pain & #depression
✅Enhancing quality of life
🔹Intense physical activity has strongest protective effect
#MetaAnalysis
👉🏽dovepress.com/effect-of-phys…
The largest #GWAS of #sarcoidosis to date identifies 28 susceptibility loci and implicates CCDC88 and #TYK2* genes.
MR suggested causal roles of IL-23R and IL-2Rβ, and risk increasing role of #BMI. @Yuan_AS
nature.com/articles/s41467-0…
*these results replicate an earlier candidate gene study of TYK2 and sarcoid sciencedirect.com/science/ar…
🚨#Apremilast (#Otezla) is associated with⬇️risk of #PsoriaticArthritis compared to #methotrexate among people with cutaneous #psoraisis (HR 0.85, 95%CI 0.79, 0.91).
Research funded by @PsoriasisInfo
sciencedirect.com/science/ar…
However, a key limitation is that IL-17/-23 inhibitors have superior efficacy for controlling cutaneous disease, the severity of which is an independent risk factor for PsA onset.
This study compares #apremilast and #methotrexate (that have more similar efficacy for cutaneous psoriasis) to see if targeted therapy reduces PsA risk independent of skin control.
🚨The incidence of #uveitis and #IBD in psoriatic disease, and vice versa, is not well described.
This study shows, among other things, that uveitis and IBD incidences are higher in #PsA than cutaneous-only #psoriasis and higher in females than males.
academic.oup.com/rheumatolog…
🚨#Tofacitinib ⬆️ #cardiovascular & #cancer risk in RA. But how relevant is this risk to people with #AxialSpondyloarthritis or #PsoriaticArthritis?
This study did not find⬆️risk of JAK compared to TNF/IL17 inhibitors in SpA. Funded by @PsoriasisInfo sciencedirect.com/science/ar…
Steven Zhao retweeted
Mendelian randomization (MR) has been criticized due to a flood of papers based on the output of a single R command.
But MR can offer valuable insights into disease etiology and can be really fun
Some interesting MR applications in examples from our work over the years 🧵 1/17
Steven Zhao retweeted
🚨 Fully funded PhD opportunity! 🚨
Join the DigiRA project at the University of Manchester & improve adherence in RA!
💻 Interdisciplinary research
💡 Innovative healthcare solutions
📍 Manchester, UK
🔗 Apply now: findaphd.com/phds/project/bi…
#PhD #DigitalHealth #Rheumatology
Steven Zhao retweeted
BSR guidelines on biologic DMARDs will guide clinicians to provide the safest, most effective care for inflammatory arthritis. BSR members, please help us shape recommendations that meet today’s challenges by sharing your feedback here: bit.ly/4freinW
