Laboratory at Purdue University using biochemistry and biophysics to study lipids and viruses. Drug development against viral hemorrhagic fevers. U2 fans!
West Lafayette, IN
Joined April 2018
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Candidates have been disclosed for the upcoming election for the American Society for Biochemistry and Molecular Biology. If you are an ASBMB member, don't forget to vote!
#vote #asbmb #JLR #jbc
asbmb.org/asbmb-today/people…
New publication! It was a wonderful collaboration with the lab of Juan Del Valle at Notre Dame. This would not be possible without his team and their peptide design. A constrained peptide that binds the Ebola virus matrix protein #ebola #VP40 #peptide
pubs.rsc.org/en/Content/Arti…
I was very happy our work was chosen to the cover this month. Especially for former postdoc Souad Amiar and collaborator Andrea Marzi
Cover - Journal of Lipid Research jlr.org/article/S0022-2275%2…
Stahelin Lab retweeted
Check out our new preprint! biorxiv.org/content/10.1101/… We found sphingolipid binding to SARS-CoV-2 M protein controls its conformation to coordinate viral assembly+release. Great collaboration with @VothGroup + @Stahelin_Lab co-led by @KimDolan_UCB, Mandira Dutta, + @souadamiar.
Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly
New preprint in collaboration with the @SteveBrohawn @VothGroup Excellent team effort demonstrating a ceramide-1-phosphate interaction in M! #membrane
biorxiv.org/content/10.1101/…
Very pleased to announce a new review in Virology put together by Ph.D. student Rokaia Sultana. This article details the strenghts and limitations of virus-like particle systems for SARS-CoV-2
#virus #sarscov2 #lipid #virology
sciencedirect.com/science/ar…
Fatty acids and membrane order matter for assembly and budding of the Ebola virus matrix protein VP40! New work from the lab. Big thanks to Andrea Marzi!
#ebola #lipidtime #membrane #VP40 #plasma_membrane
jlr.org/article/S0022-2275(2…
New collaborative work examining electrostatic interactions between the Ebola virus matrix protein VP40 and the plasma membrane at key arginine substitutions!
pubs.acs.org/doi/10.1021/acs…
#ebola #lipidtime #VP40 #membrane #filovirus
The N (nucleoprotein) interacts with anionic lipids including phosphoinositides and phosphatidylserine. New work from the lab and collaboration with the lab of Greg Voth.
#lipidtime #sars2 #membrane
jbc.org/article/S0021-9258(2…
Collaboration with Dr. Elsje Pienaar's computational lab yields a better understanding of the Ebola virus nucleoprotein's role in virus budding. #Ebola #nucleoprotein #VP40
nature.com/articles/s42003-0…
Collaboration with Dr. V. Jo Davisson's lab! New studies demonstrating potency and stability of diphyllin-derived Vacuolar-ATPase inhibitors
#Virus #pH
sciencedirect.com/science/ar…
Stahelin Lab retweeted
Abstracts Due 5/26!🌟 Explore the latest in #Phospholipid Biology at #LSHSRC! Join Antonella De Matteis @Tigem_Telethon and @VolkerHaucke in July for "Phospholipids in Aging and Disease." Topics: lipid signaling, treatments for diabetes, cancer, & more. bit.ly/3xQj5yp
ALT For over 35 years, this Science Research Conference (SRC) has presented and integrated advances in phospholipid biology and signaling to foster new national and international collaborative projects. This year’s SRC will continue to encourage and support junior investigators, trainees, women, and minority scientists to pursue phospholipid biology research, ensuring that the study of human diseases relevant to aging remains vigorous. It will also accelerate the translation of fundamental advances into novel clinical treatments through the interactions of basic and clinical researchers. Presenters will explore all aspects of phospholipids, the major components of biological membranes, which play instrumental roles in guiding cell-to-cell communication and trafficking of nutrients and proteins.
4 amazing keynotes under one roof! Join @ghotamis and @JLS_Lab with organizers @OlzmannLab and @HenneLab for #LIPDSRC plus @AntonellaDeMat4 and @VolkerHaucke with organizers @BrookeEmerling and @sharontooze01 for #LSHSRC. Register for one to attend both:
hubs.ly/Q02sPfRB0
Learn more about how the Ebola virus matrix protein (VP40) dimer is stabilized! A wonderful collaboration with the Wiest and Chapagain labs integrating computational work with in vitro and cellular studies. #ebola #vp40 #lipidtime #Virus
onlinelibrary.wiley.com/doi/…
Happy this manuscript is published, especially for Ph.D. student Bali Motsa. Demonstrates how +1 or -1 in charge (and more) can alter lipid binding, assembly, and budding of the Ebola virus matrix protein VP40.
jbc.org/article/S0021-9258(2…
#ebola #lipidtime #electrostatics #VP40
New work from our collaboration with the lab of Dr. Elsje Pienaar at Purdue. A computational model of the Ebola virus matrix protein nucleation-elongation process!
#ebola #lipidtime
journals.asm.org/doi/10.1128…
New work from the lab with integrated collaborative studies with Prem Chapagain's lab on the role of phosphatidic acid in assembly and budding of the Ebola virus. @AsbmbLrd
#lipidtime #ebola #VP40
sciencedirect.com/science/ar…
We are happy to have a new preprint online! Minor changes in electrostatics robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles biorxiv.org/content/10.1101/…
Excited to have this work published in the Journal of Lipid Research! How PI(4,5)P2 binding sites in the Ebola virus matrix protein modulate assembly and budding! KAJ the rockstar! @KristenAnnaJoh1 @jlipidres @AsbmbLrd
#lipidtime
jlr.org/article/S0022-2275(2…
Stahelin Lab retweeted
It’s Dr. Emily David, Ph.D.!
This degree was made possible by the incredible support from my family and friends, my mentor, @Stahelin_Lab and lab mates, @Purdue_MCMP dept., the @purduepharmacy, and @MbtpPurdue program.
Boiler up! @LifeAtPurdue
Photo by Chloe Smetanka
Stahelin Lab retweeted
We had a wonderful week at Madeira! Thank you all for the great discussions at the FEBS Special Meeting on Sphingolipid Biology.
It was a pleasure to host you all!
#sphingolipidbiology
#SLBiol2023
#visitmadeira
@FEBSnews @EMBOevents @CoskunPLID @BassereauTeam @Stahelin_Lab
