Giving scientists AI superpowers. Spring’s AI R&D platform was acquired by a major biotech leader in the Bay Area.
Joined November 2017
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Spring Science retweeted
have an incredible immunologist now looking for next thing due to this —
strong startup experience, drug discovery project leader, and AI+drug discovery veteran
DM me for more
16/ Finally, there’s now a group of 18 ridiculously talented, hard-working, gritty, mission-driven, and startup-battle-hardened AI engineers, scientists, and software developers – plus a great startup ops person – who are in need of a home.
A team of this caliber is as rare as they come. My loss, your opportunity. Ping me ASAP if you want details.
Spring Science retweeted
What complex tasks can a model complete? And in what environment (available tools, quality thereof)? What constraints (wall clock time, inference costs)? Eval continues to get more complex, but again, that's what we'd expect when something new is on horizon...
Spring Science retweeted
Props to Anthropic for shipping computer use. Very exciting. I'm seeing lots of interesting example use cases and also a lot of "failures" where the model ultimately can't finish the task.
...but that's maybe what you'd expect when you open a door to something new + important!
Spring Science retweeted
#newpaperalert! Morphological profiling used to classify hits in neural progenitor cells in a drug screen for Alzheimer's. HCA was used to profile the TargetMol library, showing the power of this technique for drug repurposing and discovery studies.
buff.ly/3JcdtAM
Spring Science retweeted
Applications are open for engineers and technical leadership responsible for building these platforms to join the community.
conference.latch.bio
We thank @Lux_Capital @awscloud @coatuemgmt for supporting the first homebrew computing club in the biotech industry.
Spring Science retweeted
REMINDER!
REGISTRATION FOR OUR ANNUAL MEETING CLOSES TUESDAY, OCTOBER 24th at 5PM ET.
We are near capacity for this year, and there will be NO on site registration ! Please submit your conference registration before the deadline!!!!
buff.ly/3PBBG8h
Spring Science retweeted
Why we build @springdiscovery:
"He notes that the share of target-based drugs in new approvals has grown over the years, but that there has never been a year when they surpassed the phenotypic ones."
Delighted that my recent article has been featured in the great blog of the @ScienceMagazine, Dr. @Dereklowe's In the Pipeline.
Target Based Drug Discovery - A Waste of Time?
🔗 science.org/content/blog-pos…
#drugdesign #drugdevelopment #medicinalchemistry #pharma #systemsbiology
Spring Science retweeted
Abstract submission closes September 15! Don't miss out! Submit now for poster and podium presentations! buff.ly/3pLqMlx
Spring Science retweeted
It's #meetingmonday, and we're thrilled to thank our main session and keynote spotlight sponsors Cytotronics, @RevvityInc and @SpringDiscovery ! Without our sponsors, SBI2's annual meeting would not be possible! See the agenda here: buff.ly/44O3nir
Spring Science retweeted
You may also view these three components as part of a continuous loop, a discovery machine of sorts. A scientific belief that guides an experiment, followed by data analysis that ultimately informs how this belief should be altered for the next iteration through the loop.
Spring Science retweeted
We’ve spent years quietly building a discovery engine @springdiscovery that gives scientists fighting aging the tools they deserve.
Feels good to be sharing more of our tech publicly — springdiscovery.com/technolo…
Spring Science retweeted
Scientists should step into the lab and feel like batman walking into the bat cave. Surrounded by the best R&D tools at the ready.
Spring gives scientists superpowers.
Spring Science retweeted
16/ PS Like many in bio, it’s been HUMBLING seeing our team respond to this.
Spring's rallying cry since founding has been “Progress Every Week!” Since late Feb when we saw the promise of aging tech for COVID-19, I've witnessed nonstop heroics to honor this value.
More soon.
Spring Science retweeted
15/ The implications of tech that can help search for therapies for immune aging are wide-reaching, far beyond COVID-19.
We need new tools capable of doing so in a high-throughput, systematic manner. This is our mission @springdiscovery — read more:
medium.com/spring-discovery/…
Spring Science retweeted
14/ ...A drug we surfaced by asking the question,
“How do we help an older adult’s immune system respond to a virus like a younger person’s?”
Spring Science retweeted
13/ And excitingly, a couple days ago UCSF announced a small proof-of-concept trial testing disulfiram in COVID-19 patients.
We hope this is the first of many steps taken to explore a drug we think holds promise for different reasons than the majority of COVID therapies...
Spring Science retweeted
12/ ...including an ability to inhibit inflammasome-mediated pyroptotic cell death (nature.com/articles/s41590-0…).
These mechanisms may have direct relevance to root causes of COVID-19’s runaway inflammatory processes.
Spring Science retweeted
11/ Disulfiram was identified by leading immunologists Judy Lieberman and @WuLabHarvard and highlighted by @VirusesImmunity as having specific anti-inflammatory properties...
Spring Science retweeted
10/ Identified via unbiased screening of thousands of drugs and multiple dose responses in our platform, disulfiram shows promise for restoring age-related phenotypes: cytokine levels, t-cell phenotypes, viral infection phenotypes, more.
(In vitro, needs followup, see preprint)