@SpitaleLab

🚀🚀🚀

 Irvine, CA
spitalelab.com
Joined June 2015
  • Tweets4.1K
  • Following1.5K
  • Followers2.6K
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It certainly is, George. It certainly is.
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The Marleys were dead to begin with…..
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A tradition unlike any other
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THE OINC IS HERE! New tour-de-force with @JMTali, years in the making! Direct sequencing of chemical modifications on RNA to measure RNA localization transcriptome-wide. Read about OINC-seq here: biorxiv.org/content/10.1101/…

Quantification of subcellular RNA localization through direct detection of RNA oxidation

Across cell types and organisms, thousands of RNAs display asymmetric subcellular distributions. The study of this process often requires quantifying abundances of specific RNAs at precise subcellu...

biorxiv.org
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A tradition unlike any other
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BIGLY congratulations to @raflynn5 #glycoRNA! @NIH_CommonFund's Transformative Research Award! #NIHHighRisk hscrb.harvard.edu/news/flynn…

Ryan Flynn Awarded Prestigious NIH Director's Transformative Research Award | HSCRB

hscrb.harvard.edu
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41rst orbit complete. Nominal.
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Top 10
50cent
@50cent10 Jun 2024
My country album on the way Beyoncé ain’t got shit on me. LOL 😆 gunitbrands.com
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Robert Spitale retweeted
50cent
@50cent10 Jun 2024
My country album on the way Beyoncé ain’t got shit on me. LOL 😆 gunitbrands.com
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Interested in cell-surface (gasp) and glyco (gasp again) RNA? Very exciting research in this area! A great read from @raflynn5 and the group here: cell.com/cell-chemical-biolo…
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Charlie Mace@Charles_Mace4 Mar 2024
Newest ChemRxiv preprint from the lab - "Colorimetric detection of fentanyl using a supramolecular displacement assay". We wanted a simple way for first responders to identify unknown white powders without putting themselves at risk. doi.org/10.26434/chemrxiv-20…

Colorimetric detection of fentanyl using a supramolecular displacement assay | ChemRxiv

Fentanyl is a potent synthetic opioid with an alarmingly low lethal dosage of 2 mg. The equipment necessary to detect fentanyl in field settings (e.g., handheld spectrometers) is restricted to highly...

chemrxiv.org
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Its not as cool as RNA, but it turns out DNA can form structures too! New paper from our lab w/ @TWBredy: "G4-DNA is a critical molecular switch underlying the regulation of neuronal transcription" pubmed.ncbi.nlm.nih.gov/3841…

DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory - PubMed

The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and...

pubmed.ncbi.nlm.nih.gov
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Tim Allen@AllenNeuroLab4 Feb 2024
Projections from thalamic nucleus reuniens to hippocampal CA1 area enable context value updating biorxiv.org/content/10.1101/…

Projections from thalamic nucleus reuniens to hippocampal CA1 area enable context value updating

The ability to extinguish contextual fear in a changing environment is crucial for animal survival. The ‘classic’ neuronal circuit of contextual fear extinction includes the medial prefrontal cortex...

biorxiv.org
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🚨🚨🚨Awesome new preprint from @tfmPhD! Important consideration when using riboseq for any analysis!
bioRxiv@biorxivpreprint31 Dec 2023
Comparison of software packages for detecting unannotated translated small open reading frames by Ribo-seq biorxiv.org/cgi/content/shor… #bioRxiv
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bioRxiv@biorxivpreprint31 Dec 2023
Comparison of software packages for detecting unannotated translated small open reading frames by Ribo-seq biorxiv.org/cgi/content/shor… #bioRxiv
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How are timescales integrated in biology? Glucose fluxes (sec) are captured by transcription (hrs) — but how? Learn more in our new paper! #LLPS #timescales #proximity #spatiotemporal #condensate #metabolism #metabolon #glucose #glycolysis Thanks to @MDPIOpenAccess @UCI_SPPS mdpi.com/2072-6694/16/1/16
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New paper from the lab with @YongshengShi in @NatureSMB: The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery nature.com/articles/s41594-0…
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New paper out now in Nature Communications w/@TWBredy "Fear extinction is regulated by the activity of long noncoding RNAs at the synapse" Excited that this one is out now. There are plenty of new ncRNA roles to find OUTSIDE the nucleus! nature.com/articles/s41467-0…
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