@EdKuijper2

microbiota studies, Cdiff, AMR and fungal infections.

 Leiden, The Netherlands
Joined January 2018
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The Peggy Lillis Foundation (cdiff.org/) invites clinicians, researchers, scientists, pharmacists, and industry professionals to submit abstracts for the November 19-20 2026 Clostridioides difficileScientific Symposium. The submission deadline is October 23, 2026.

C. Diff Education & Advocacy | Peggy Lillis Foundation

The leading C. diff patient advocacy organization. Learn about C. difficile symptoms, treatment, and recovery — and find out how to take action.

cdiff.org
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This is a study that we need...... bmjopen.bmj.com/content/16/8…

Fecal microbiota transplantation versus vancomycin or fidaxomicin in Clostridioides difficile...

Introduction Clostridioides difficile infection (CDI) is a leading cause of healthcare-associated diarrhoea in adults, with recurrence rates of 15%–25% after a first episode and up to 65% after...

bmjopen.bmj.com
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Ed Kuijper retweeted
Wiep Klaas Smits@SmitsLabSep 11
It's a wrap! #ICDS2026 has come to an end. As usual, flawless execution, great crowd. There will be another ICDS in two years - but not organised by Maja Rupnik anymore. Lots of respect and appreciation for what she has done over the past decades for the #cdiff community.
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Not the first study, usually approx 20%. Much higher than for other enteropathogens and complicating IPC and outbreak investigations
Wiep Klaas Smits@SmitsLabSep 3
Multi-strain Clostridioides difficile infection: Increased detection and clinical implications. sciencedirect.com/science/ar…
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Interesting assocation of macrolides with aminoglycosides resistancy.
Wiep Klaas Smits@SmitsLabAug 3
🚨publication alert: Collateral effects of antibiotic resistance in Campylobacter jejuni - academic.oup.com/femsle/arti…

Collateral effects of antibiotic resistance in Campylobacter jejuni

Collateral effects in antibiotic sensitivity related to antibiotic resistance in Campylobacter jejuni.

academic.oup.com
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ICDS 2026: see icds.si/programme-abstract-b…

PROGRAMME & ABSTRACT BOOK – ICDS

icds.si
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Ed Kuijper retweeted
Wiep Klaas Smits@SmitsLabJun 25
[🔔] Publication alert! The CloDiCo trial is now published in @NatureComms @NaturePortfolio (Editor's choice!). This is the work of an amazing team, and led by PhD student Annefleur Hensen. Check out this thread [👇] for a summary of the study. nature.com/articles/s41467-0… 1/10

Experimental human colonisation with non-toxigenic Clostridioides difficile: a placebo-controlled...

Nature Communications - Experimental human colonisation with non-toxigenic Clostridioides difficile shows that antibiotic-mediated microbiota disruption, particularly prolonged treatment, increases...

nature.com
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Bundibugyo ebolavirus outbreak in the Democratic Republic of the Congo and Uganda: rapid assessment from the ESCMID Emerging Infections Subcommittee @CMIJournal @ESCMID clinicalmicrobiologyandinfec…

Bundibugyo Ebolavirus outbreak in the Democratic Republic of the Congo and Uganda: rapid assessment...

The ongoing outbreak of Ebola virus disease (EVD) caused by Bundibugyo ebolavirus (BDBV) in the Democratic Republic of the Congo (DRC) and Uganda represents a major regional public health emergency...

clinicalmicrobiologyandinfection.org
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Ed Kuijper retweeted
Wiep Klaas Smits@SmitsLabMay 19
Not just passengers: Phages as agents of genetic exchange in fecal microbiota transplantation sciencedirect.com/science/ar…
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Andes hantavirus outbreak on a cruise ship - an ESCMID Emerging Infections Subcommittee (EIS) rapid assessment - Clinical Microbiology and Infection clinicalmicrobiologyandinfec…

Andes hantavirus outbreak on a cruise ship—an European Society of Clinical Microbiology and...

The ongoing cluster of hantavirus infections associated with the cruise ship MV Hondius represents an unusual but instructive event at the intersection of zoonotic spillover, human mobility, confined...

clinicalmicrobiologyandinfection.org
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Ed Kuijper retweeted
Wiep Klaas Smits@SmitsLabMay 11
New bookchapter published! The book Clostridioides difficile has a chapter on Nanoluciferase use by Jeroen Corver, Ana Paiva and myself: link.springer.com/book/10.10… Also check out the contributions of all the other experts in this volume!

Clostridioides difficile

link.springer.com
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Ed Kuijper retweeted
Wiep Klaas Smits@SmitsLabMar 10
Paper 🚨: in this Narrative Review we describe the challenges and opportunity of a microbiome research facility, based on our experiences at @LUMC_Leiden with Center for Microbiome Analyses and Therapeutics (CMAT) #ESGHAMI @ESCMID @CMIJournal @EdKuijper2 sciencedirect.com/science/ar…
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Ed Kuijper retweeted
Wiep Klaas Smits@SmitsLabMar 6
🚨Publication alert! In this manuscript we describe the characterization of the non-toxigenic C. difficile (#NTCD) strain L-NTCD03 that we have used in our controlled human colonization experiments. academic.oup.com/femsmicrobe…

Characterization of the clade 4 non-toxigenic C. difficile isolate L-NTCD03 carrying the cfr(B) gene

This manuscript describes characteristics of the clade 4 non-toxigenic Clostridioides difficile isolate L-NTCD03.

academic.oup.com
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Ed Kuijper retweeted
Wiep Klaas Smits@SmitsLabMar 6
📢Publication alert: Clinical prevalence of collateral sensitivity: a systematic exploration of multicentre antimicrobial surveillance data 💊wonderful work from Coen van Hasselt's lab, with a minor contribution from yours truly - sciencedirect.com/science/ar…
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clinicalmicrobiologyandinfec… Review of our experiences in the past 6 years to establish a Microbiota Center in an academic setting with many stakeholders and an excellent research group of George Zeller. @SmitsLab @NicolasBenech2 @CMIJournal @EurFmt

How to set up and manage a microbiome research facility

The increasing number of therapeutic intervention studies in the microbiome field has sparked broad interest among clinicians and scientists to incorporate microbiome analyses in their research....

clinicalmicrobiologyandinfection.org
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Amazing data on the Cfr -mediated antibiotic resistance in Cdiff. Typical a One Heath resistance mechanism? Also found in LA-MRSA and VRE...
Wiep Klaas Smits@SmitsLabJan 13
Epidemiology suggests that cfr(B) is associated with PhLOPSa resistance in C. difficile, but is this causative? Yes it is. We show this in our most recent preprint: biorxiv.org/content/10.64898…

Characterization of the clade 4 non-toxigenic C. difficile isolate L-NTCD03 carrying the cfr(B) gene

Clostridioides difficile infection (CDI) is a toxin-mediated gastro-intestinal disease. Yet, C. difficile is a phylogenetically diverse species that includes many non-toxigenic strains. In general,...

biorxiv.org
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Ed Kuijper retweeted
JAMA
@JAMA_current27 Dec 2025
Clostridioides difficile is a gram-positive spore-forming anaerobic bacterium that can produce toxins. Learn more about the epidemiology, diagnosis, and treatment of recurrent C difficile infections in this JAMA Insights: ja.ma/3N2AKdz
A flowchart titled, 'Diagnosis of Recurrent Clostridioides difficile Infection'. It shows steps for diagnosis from suspected infection to treatment options. Text includes, 'Sensitive screening assay', 'Specific test', and treatment options like 'Fecal microbiota transplant'.

ALT A flowchart titled, 'Diagnosis of Recurrent Clostridioides difficile Infection'. It shows steps for diagnosis from suspected infection to treatment options. Text includes, 'Sensitive screening assay', 'Specific test', and treatment options like 'Fecal microbiota transplant'.

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As 2025 comes to an end, it is time to reflect on an exceptionally productive scientific year (22 manuscripts so far). I am grateful for these interactions, proud of the work, and looking forward to more exciting science with my team in 2026! sites.google.com/view/expbac…

ExpBac @ LUMC

Image: CDC, Jennifer Oosthuizen

sites.google.com
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Donor screening for #FMT gets ever more complicated, but is there rationale for this? Great to play a part in this critical appraisal and international Delphi process on this issue, now out in @Gut_BMJ: gut.bmj.com/content/early/20… @EdKuijper2 @IHepatology @ImperialMDR @EurFmt
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Excellent news from Gut....our article "Towards Optimising and Standardising Donor Screening for Faecal Microbiota Transplantation" has been accepted. International collaboration with FMT experts, completed with a Delphi-survey. More news in the following weeks.
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