@Sixt_Lab

Using mainly immune cells, we try to understand how cells migrate, change shape and interact in tissues. #immunecells #cellmigration Run by lab members!

 @ISTAustria
sixt.pages.ist.ac.at/
Joined March 2022
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We are really happy to see @mehmetintheory, @zanealsberga and @jonna_alanko‘s work on self generated gradients in collective migration out! Another great collaboration with @EdouardHannezo ‘s lab. Check the pre-print 👉 tinyurl.com/36dsz47z
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The Image & Optics Facility @ISTAustria is expanding it’s image analysis services and has a vacant position for a service oriented *Image Analysis Specialist* with a strong interest for data infrastructure organization🔬🧑‍💻📈 ista.ac.at/en/job/?title=Ima…

Job details

Job details

ista.ac.at
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We teamed up with @ISTAsustainable and Saki, visiting artist @ISTAustria, and collected used non-contaminated gloves. The result was a beautiful dress worth a red carpet event in the lab. Check more of her work 👉sakitheartist.com/ 📸juergenhofmann.com/
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An institute like ISTA consumes around 1700 gloves/day. These gloves are often discarded after a single use. Although nitrile CAN be recycled, Europe lacks sufficient infrastructure to process this material, so the gloves end up being incinerated.
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If you would like to help science become more sustainable: • Reuse gloves when possible, they can be sterilized with no change in their properties: 📄twtr.to/uPYLx • Don't overstock-gloves do expire!
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Last Friday our @ERC_Research synergy team #pushingcell got together @institut_curie in Paris. Great discussion with @BassereauTeam, @PierreSens group and Anna Akhamnova’s team!
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👻Trick or treat?🎃 Here is a treat 🍬 In our new perspective article @mi_riedl dives into the self-organizing principles behind actin polymerization and the Belousov-Zhabotinsky reaction. Two seemingly different systems, one underlying principle. 👉 shorturl.at/hyUY3
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🧵(1/6) How do immune cells know where to go? It has been proposed that cells simply respond to externally established gradients of chemokines, but we think that’s not all…
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(5/6) DCs don't just passively follow chemical cues! CCR7 senses CCL19 and actively shapes the distribution of chemokine. This dual function allows immune cells to generate their own gradients, guiding their collective migration in complex environments more effectively.
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(6/6)You can read more about it here: science.org/doi/10.1126/scii… Congratulations to all the authors involved!!

CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration

Dendritic cells modulate local chemokine gradients resulting in robust self-organizing patterns of collective migration.

science.org
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If you are attending the @lindaunobel Laureate Meeting this month you might meet our postdoc Mario (@mj_avellaneda)! We are all looking forward to hear about all the amazing talks that will happen…
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Here is a peek at some bits from the story, a video with the images from @christlet and some of his comments, and a podcast with @Sixt_Lab @RolandSoldner protocolsmethods.springernat…
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The directed cell migration GRC is happening next January and there are still some places available! Don’t miss out on an interactive and engaging meeting. Find out more here: grc.org/directed-cell-migrat…
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📣 JOB ALERT!! 🔬 Time to get into the details of amoeboid #collectivemigration! 3 years funded postdoc position in collaboration with @PielMatthieu, @mcoppey and Voituriez labs to decrypt the cellular and molecular mechanisms of CAM (science.org/doi/10.1126/scia…)
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Talk alert 🚨Don’t miss Michael’s talk tomorrow in Global Immunotalks @globalimmuno! 6pm CET, link 👇
Global Immunotalks@globalimmuno14 Nov 2022
Looking forward to our next #globalimmuno talk this Wednesday, November 16th at 9am PST, noon EST, 5pm GMT by Dr. Michael Sixt. Title: "Leukocyte locomotion - the single cell perspective" LINK: ucsd.zoom.us/j/91053505061
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Thrilled to share our work in @Nature showing elevated viscosity counterintuitively increases cell motility and imprints mechanical memory in tumor cells enabling them to disseminate more efficiently in vivo! Thanks to #NCI, @KaustavBera11, @SXS_biophysics nature.com/articles/s41586-0…
Art created by Dr. Selma A. Serra from Universitat Pompeu Fabra, Barcelona, Spain

ALT Art created by Dr. Selma A. Serra from Universitat Pompeu Fabra, Barcelona, Spain

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