We aim to understand how the supporting stroma of the tumour micro environment regulates immune activity from early stages of disease to promote carcinogenesis.
London, England
Joined March 2019
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Shields Lab retweeted
In vivo fluorescent labeling and tracking of extracellular matrix | Nature Protocolsm nature.com/articles/s41596-0…
Shields Lab retweeted
Neutralization of NET-associated human ARG1 enhances cancer immunotherapy science.org/doi/10.1126/scit…
Shields Lab retweeted
Hepatic macrophages are more heterogeneous than once thought: the markers that define them, the signals driving their development and their unique functions in the healthy and diseased liver. @ImmunityCP @KC_DC_01 @MartinGuilliams
cell.com/immunity/fulltext/S…
Shields Lab retweeted
Does ECM composition determine immune cell phenotype?
Yes! In our new work on #ECM #immunity, we found tumour ECM induces a population of TAMs found in ovarian cancer with tissue remodelling and immunoregulatory properties. biorxiv.org/cgi/content/shor…
Shields Lab retweeted
I am thrilled to share our paper with you all today! We unraveled how dural lymphatic vessel dysfunction assists the behavioral response to peripheral inflammation: nature.com/articles/s43587-0…
Shields Lab retweeted
Happy to see my artwork featured in @LabonaChip cover!
Check out our article here,
pubs.rsc.org/en/content/arti…
Shields Lab retweeted
A pan-cancer metabolic atlas of the tumor microenvironment cell.com/cell-reports/fullte…
Shields Lab retweeted
🎉 Happy International #DayOfImmunology!
A huge thank you to all the #immunologists championing the critical role of #vaccination & helping us understand how #VaccinesWork 👏
Our President Prof @AkbarArne shares a message of thanks to every one of you ⤵
#ThankYouImmunology 1/3
Shields Lab retweeted
Thank you to @CRUKresearch & @NIHRresearch for funding this important #Cytosponge trial! This is the next step in getting our invention to more people around the UK to increase the #EarlyDetection of #BarrettsOesophagus @CRUKCamEarlyDx @Cyted_UK @MedtronicUK
Together with @NIHRresearch, we’re investing £6.4m to support the latest Cytosponge trial. The trial aims to provide the cancer detection & mortality endpoint data necessary to establish Cytosponge in clinical care as a tool to detect Barrett’s oesophagus: bit.ly/3kebO1g
Shields Lab retweeted
In the wake of #COVID19 we must minimise damage to UK research infrastructure, preventing cuts to thousands of scientific jobs essential for treating the world’s deadliest diseases.
Unite with @MRC_CU Dr Frezza this Wednesday 28thOct asking Government to protect #ResearchAtRisk
Shields Lab retweeted
...and the @Shields_Lab is back! The last time I was here, there were no leaves on the trees 😳. Thanks to everyone involved in the huge effort to get us in to the @MRC_CU, and get us in safely. Now, where is my lab coat again?
Shields Lab retweeted
In case you missed yesterday's show, you can catch up now here:
camfm.co.uk/player/36994
#CambridgeZeroClimateTalks #ClimateChange #Sustainability #Environment
Today 4-5pm @camfm972. Our guests include Dimitri Zenghelis @DimitriZ, Dr Ruchi Choudhary @Cambridge_Eng, Tom Bragg @CCFcambridge, Will Moody @MRC_CU and Flannery (7yrs).
Because the more informed we are, the better decisions we can make.
#CambridgeZeroClimateTalks
Shields Lab retweeted
Will is a PhD student at the MRC Cancer Unit @MRC_CU @Cambridge_Uni. He took part in a coaching programme called Engage for Change @CambridgeHub @CambridgeSust, and now shares his vision for positive environmental change.
#PostcardsFromHome #CambridgeZero
#ClimateChange
Shields Lab retweeted
Another inspiring person for #WomenInScience
@HafsaMunir11 postdoc @Shields_Lab who is her wonderfully #authentic self, always plugged into Dr Dre (?!) headphones, bopping about @MRC_CU, neutrophil nerd with awesome paper 👇 biorxiv.org/content/10.1101/…
Shields Lab retweeted
A must read.... A framework for advancing our understanding of cancer-associated fibroblasts
Our #openaccess Consensus Statement provides a framework for advancing our understanding of cancer-associated fibroblasts authored by 29 leaders in the field! Why not have a read here....go.nature.com/2vs60uX @NatResCancer @CSHL @cshlbanbury
Shields Lab retweeted
Mini lymph nodes grow in tumours and predict immunotherapy outcomes? Crikey! Triple set of publications in @nature last week by @jonsson_lab, @JenWargoMD and @fridmanwh.
nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
Shields Lab retweeted
Who knew #neutrophils were so interesting @HafsaMunir11? Our preprint showing drivers and effects of CAF-induced NETs is online
Stromal Amyloid β drives Neutrophil extracellular trap formation to augment tumour growth biorxiv.org/cgi/content/shor… #bioRxiv
