@SelbachLab

Real flying ion Circus studying the proteome and its dynamics @BIMSB_MDC @MDC_Berlin

 Berlin, Deutschland
Joined May 2017
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MEK inhibition + growth factor → unexpected JNK activation 💥 Dual inhibition = significantly impaired tumor cell growth 🔬 SPIED-DIA = a powerful tool to dissect signaling & resistance #phosphoproteomics #cancerresearch #SPIED_DIA #MEKinhibition #DIA #precisionmedicine
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We present SPIED-DIA – a spike-in enhanced phosphoproteomics method combining DIA with targeted sensitivity to uncover synergistic signaling in colorectal cancer cells. 👉 [rdcu.be/enPF2](rdcu.be/enPF2)
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What happens to all those alternative transcripts? 👉 Many are translated 👉 Proteolytic processing adds even more diversity Integrated mRNA & protein isoform landscape now out on bioRxiv! doi.org/10.1101/2025.04.16.6… #proteomics #transcriptomics #systemsbiology
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Replying to @michaelsteidel1 @DemichevLab
Should be up by tomorrow the latest!
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Excited to share our new paper in MCP! 🎉 DIA with Spike-In SILAC (DIA-SiS) boosts proteome coverage and quantification. Check it out: doi.org/10.1016/j.mcpro.2024… #Proteomics #MassSpec #Research
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Celebrating summer with our annual group barbecue
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Read our latest preprint on targeted phosphoproteomics: "Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells.": biorxiv.org/cgi/content/shor… #Phosphoproteomics #DIA #CancerResearch #Signaling #ColonCancer
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Read the latest preprint on medRxiv: Cross-platform Clinical Proteomics using the Charite Open Standard for Plasma Proteomics (OSPP)
Ralser Lab@RalserLab11 May 2024
Want to do absolute quantitative plasma proteomics, with an internal standard that costs you less than 1€ per sample? Have a look at our OSPP medrxiv.org/cgi/content/shor…
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Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification. Read our new preprint on bioRxiv. #SILAC #DIA #Proteomics biorxiv.org/content/10.1101/…

Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and...

Data Independent Acquisition (DIA) is increasingly preferred over Data Dependent Acquisition (DDA) due to its higher throughput and fewer missing values. Whereas DDA often utilizes stable isotope...

biorxiv.org
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Read our latest work on how phosphorylation in Intrinsically Disordered Regions (IDRs) affects protein-protein interactions in Nature Communications. @TRrustemi nature.com/articles/s41467-0… #IDR #phosphorylation

Pathogenic mutations of human phosphorylation sites affect protein–protein interactions

Nature Communications - Here the authors characterise the impact of phosphorylation site mutations in intrinsically disordered regions (IDRs) on protein-protein interactions, highlighting the...

nature.com
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Enjoy good lectures about DIA and the sun here in South Africa #UPSS2024
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We would like to congratulate Fabian @CosciaLab for being awarded the European Research Council (ERC) Starting Grant 👏. #ERC mdc-berlin.de/news/press/erc…

ERC Starting Grant awarded to Fabian Coscia

Whether aggressive cancer cells can spread unchecked depends, to no small degree, on their cellular neighborhood. Fabian Coscia wants to analyze exactly what happens at the proteome level during this...

mdc-berlin.de
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Wishing our institute, MDC-BIMSB, a very happy 15th birthday 🥳 mdc-berlin.de/news/press/max… #MDC #BIMSB

The Max Delbrück Center celebrates 15 years of MDC‑BIMSB

Internationally renowned for pioneering achievements and geared to inter-institutional cooperation: 22 research groups at the Berlin Institute for Medical Systems Biology in the Max Delbrück Center...

mdc-berlin.de
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Our latest preprint investigates the pathogenic mutations of human phosphorylation sites that affect protein-protein interactions. Using peptide-based interaction proteomics, more insights regarding the transcription factor GATAD1 were unveiled. @TRrustemi biorxiv.org/content/10.1101/…

Pathogenic mutations of human phosphorylation sites affect protein-protein interactions

Despite their lack of a defined 3D structure, intrinsically disordered regions (IDRs) of proteins play important biological roles. Many IDRs contain short linear motifs (SLiMs) that mediate protein...

biorxiv.org
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Last week we went on a nice kayaking trip to Lübbenau/Spreewald 😃 #ProteomeDynamics #MS
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We completed a 5x5 km team relay yesterday. Some of us already look forward to running again next year.
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