@SelbachLab

Real flying ion Circus studying the proteome and its dynamics @BIMSB_MDC @MDC_Berlin

 Berlin, Deutschland
Joined May 2017
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We present SPIED-DIA – a spike-in enhanced phosphoproteomics method combining DIA with targeted sensitivity to uncover synergistic signaling in colorectal cancer cells. 👉 [rdcu.be/enPF2](rdcu.be/enPF2)
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MEK inhibition + growth factor → unexpected JNK activation 💥 Dual inhibition = significantly impaired tumor cell growth 🔬 SPIED-DIA = a powerful tool to dissect signaling & resistance #phosphoproteomics #cancerresearch #SPIED_DIA #MEKinhibition #DIA #precisionmedicine
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What happens to all those alternative transcripts? 👉 Many are translated 👉 Proteolytic processing adds even more diversity Integrated mRNA & protein isoform landscape now out on bioRxiv! doi.org/10.1101/2025.04.16.6… #proteomics #transcriptomics #systemsbiology
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Excited to share our new paper in MCP! 🎉 DIA with Spike-In SILAC (DIA-SiS) boosts proteome coverage and quantification. Check it out: doi.org/10.1016/j.mcpro.2024… #Proteomics #MassSpec #Research
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Celebrating summer with our annual group barbecue
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Read our latest preprint on targeted phosphoproteomics: "Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells.": biorxiv.org/cgi/content/shor… #Phosphoproteomics #DIA #CancerResearch #Signaling #ColonCancer
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Read the latest preprint on medRxiv: Cross-platform Clinical Proteomics using the Charite Open Standard for Plasma Proteomics (OSPP)
Ralser Lab@RalserLab11 May 2024
Want to do absolute quantitative plasma proteomics, with an internal standard that costs you less than 1€ per sample? Have a look at our OSPP medrxiv.org/cgi/content/shor…
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Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification. Read our new preprint on bioRxiv. #SILAC #DIA #Proteomics biorxiv.org/content/10.1101/…

Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and...

Data Independent Acquisition (DIA) is increasingly preferred over Data Dependent Acquisition (DDA) due to its higher throughput and fewer missing values. Whereas DDA often utilizes stable isotope...

biorxiv.org
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Read our latest work on how phosphorylation in Intrinsically Disordered Regions (IDRs) affects protein-protein interactions in Nature Communications. @TRrustemi nature.com/articles/s41467-0… #IDR #phosphorylation

Pathogenic mutations of human phosphorylation sites affect protein–protein interactions

Nature Communications - Here the authors characterise the impact of phosphorylation site mutations in intrinsically disordered regions (IDRs) on protein-protein interactions, highlighting the...

nature.com
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Enjoy good lectures about DIA and the sun here in South Africa #UPSS2024
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We would like to congratulate Fabian @CosciaLab for being awarded the European Research Council (ERC) Starting Grant 👏. #ERC mdc-berlin.de/news/press/erc…

ERC Starting Grant awarded to Fabian Coscia

Whether aggressive cancer cells can spread unchecked depends, to no small degree, on their cellular neighborhood. Fabian Coscia wants to analyze exactly what happens at the proteome level during this...

mdc-berlin.de
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Wishing our institute, MDC-BIMSB, a very happy 15th birthday 🥳 mdc-berlin.de/news/press/max… #MDC #BIMSB

The Max Delbrück Center celebrates 15 years of MDC‑BIMSB

Internationally renowned for pioneering achievements and geared to inter-institutional cooperation: 22 research groups at the Berlin Institute for Medical Systems Biology in the Max Delbrück Center...

mdc-berlin.de
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Our latest preprint investigates the pathogenic mutations of human phosphorylation sites that affect protein-protein interactions. Using peptide-based interaction proteomics, more insights regarding the transcription factor GATAD1 were unveiled. @TRrustemi biorxiv.org/content/10.1101/…

Pathogenic mutations of human phosphorylation sites affect protein-protein interactions

Despite their lack of a defined 3D structure, intrinsically disordered regions (IDRs) of proteins play important biological roles. Many IDRs contain short linear motifs (SLiMs) that mediate protein...

biorxiv.org
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Last week we went on a nice kayaking trip to Lübbenau/Spreewald 😃 #ProteomeDynamics #MS
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We completed a 5x5 km team relay yesterday. Some of us already look forward to running again next year.
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Interested in joining our Proteome Dynamics lab in Berlin? We are offering a postdoc position: tinyurl.com/y99xvxad
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Looking for a method to identify drug targets? Our new paper on drug target identification by quantitative proteomics is now online: doi.org/10.1002/cmdc.2022003…

Compound Interaction Screen on a Photoactivatable Cellulose Membrane (CISCM) Identifies Drug Targets

Parallel identification: We present a new compound interaction screen on a cellulose membrane (CISCM) that combines undirected photoimmobilization of compounds on cellulose with affinity purificati...

chemistry-europe.onlinelibrary.wiley.com
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Proteomics Pride @MDC_Berlin in celebration of #CSDBerlin #proteomics #pride #mdcberlin
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How can you predict kinase activity in phosphoproteomic data? This database allows you to do this, even for poorly annotated kinases. Read more in this new paper: doi.org/10.1021/acs.jproteom…”
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Given the energy required for protein synthesis, degrading proteins seems to be wasteful. Read about the physiological functions of protein degradation in this new review: doi.org/10.1146/annurev-cell…

Physiological Functions of Intracellular Protein Degradation

While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process:...

annualreviews.org
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