Hi Otter, the code applies to neurons born in the larva which will make the bulk of the adult brain. We propose that it stores the order in which individual neurons are born from the stem cells (neuroblasts in insects)
Late born neurons from each lineage form trajectories, with consecutively born neuron types arranged by birth order. By aligning 83 such trajectories, we directly compared how expression dynamics unfold across lineages. 5/8
With unprecedented 38× coverage, our atlas resolves single neuron clusters and shows that separate waves of neurogenesis use different modes of molecular identity encoding: discrete in early born and continuous in late born. 3/8
Seba retweeted
So proud of @istvan_taisz and @GaliliDana for this elegant and rich scientific story that finally links sex pheromone circuits to dimorphic behaviour in #Drosophila. And a lovely 🧵 to boot. Read and enjoy!
Sex pheromones are a great entry point to understand #brain #circuits. @istvan_taisz and I investigated how cVA, the canonical #Drosophila #pheromone, is processed to control social #behaviour – and how flies use cVA to “see” in the dark! biorxiv.org/content/10.1101/… 1/14
ALT Drosophila male pheromone signals are separated into two central brain processing pathways cVA is used as a positional cue owing to an active mechanism for bilateral contrast Position (where) and identity (what) are separated at the 3rd layer of cVA processing Multimodal integration and distinct response kinetics increase signal specificity
Many thanks to all authors including @MarinaGkantia @as_bates @sfrechter Laura Blackie Amy McCarthy @sutcliffe_ben Alessio Strano Yoshi Aso @HHMIJanelia
We have developed a new fully genetically encoded tracing system, #BAcTrace, and validated it in #Drosophila. This makes the fly the first animal with such systems for both retrograde and anterograde tracing (trans-Tango, TRACT). 3/11
