Movement disorders neurology remains an act of watching. @janealty1 & @vertigologist explore computer vision for the detection of deterioration in #Parkinsons. But if "no effective intervention or care response is available, have we actually helped"? nature.com/articles/s41531-0…

Mission Therapeutics @MISSIONTherapeu announces dosing of first #Parkinsons patient in the Phase 1b study of their USP30 inhibitor MTX325. The study is taking place in UK, Europe & Australia. Readout is anticipated in late 2027 missiontherapeutics.com/miss…

Curiously, both of these ARBs are traditionally considered non-CNS penetrant "both produce insurmountable, slowly reversible AT1 blockade with prolonged receptor residence times, whereas losartan binds in a surmountable, rapidly dissociating manner"

Using large-scale hospital electronic health records of the University of California health system (n=890K hypertensive patients), researchers report Angiotensin receptor blockers irbesartan & olmesartan were associated with lower incident #Parkinsons risk onlinelibrary.wiley.com/doi/…

XellSmart presented 6 months post-transplant data for their Phase I trial of their off-the-shelf #Parkinsons cell therapy XS411, & announces successfully completion of enrollment for the Phase 2 trial of XS411 prnewswire.com/news-releases…

Something researchers to explore: The GBA1 Canada initiative (G-can) - a pre-competitive, collaborative, open-science platform accelerating research & treatment development for GBA1-related #Parkinsons journals.sagepub.com/doi/10.…

New research suggests dietary patterns/habits in isolated REM sleep behavior disorder is associated with gut microbiome dysbiosis & predicts neurodegenerative progression, highlighting diet–microbiome interactions as modifiable factors movementdisorders.onlinelibr…

Researchers virtually screen of 9.4k compounds (2.6k FDA-approved drugs, 6.7k African natural products) against the ATP-binding pocket of LRRK2-G2019S, & identify Rimonabant, Gallagic acid, Acalabrutinib, & Atovaquone as repurposable candidates nature.com/articles/s41598-0…

Researchers report a case of #Parkinsons caused by a de novo SNCA triplication with longitudinally evaluated gene expression in whole blood & platelets at 2 disease stages: early PD (age 41) & Parkinson's disease dementia (age 44) movementdisorders.onlinelibr…

New research from the GP2 team finds that the GCH1 p.Ser80Asn variant is a rare, East Asian-enriched risk variant for #Parkinsons movementdisorders.onlinelibr…

Another week, another paper for @GeorgeTofaris & colleagues This week, they report the epitope accessibility & topology of extracellular vesicle-associated α-synuclein proteoforms, rather than their abundance alone, discriminate synucleinopathy subtypes academic.oup.com/brain/advan…

New review explores resilience & vulnerability in the midbrain dopamine system during aging; "Elucidating these neuroadaptive mechanisms could offer a path toward preserving dopamine neuron function across the lifespan" & possibly preventing neurodegen. cell.com/trends/neuroscience…

New editorial raises concerns about Vitamin B6 levels in #Parkinsons, & the need for monitoring them movementdisorders.onlinelibr…

Towards a better definition of patient-centered therapeutic strategy of #Parkinsons: A new opinion paper proposes "pragmatic, consensus-based principles for fully individualized, preference-sensitive pharmacological care across the patient journey" link.springer.com/article/10…

Perspectives on ionizing radiation & #Parkinsons "Emerging evidence from epidemiological studies in humans exposed to ionizing radiation (IR) suggests a positive association between IR & a specific neurological disorder, Parkinson’s" nature.com/articles/s41531-0…

Results in the Parkinson's Precision Medicine Initiative (PPMI) indicate that a-synuclein-seed amplification assay testing results are highly consistent over time movementdisorders.onlinelibr…

"Artistic expression offers unique insights beyond structured assessments, fostering empathetic clinician–patient communication, & supporting a more holistic, person-centered approach to PD care". State of the “Art” in Freezing of Gait from @basbloem et al onlinelibrary.wiley.com/doi/…

The 2026 therapeutic development pipeline for Frontotemporal lobar degeneration has been published alz-journals.onlinelibrary.w…

"Intranigral AAV8-Irisin delivery did not produce statistically significant improvement in either motor performance or dopaminergic neuron survival" in a preclinical #Parkinsons (AAV9-A53T mouse) model. Peripheral AAV8-Irisin had no impact as well frontiersin.org/journals/agi…

Press summary associated with this research: medicalxpress.com/news/2026-…