Viral Desulfovibrio (DSV) species have been linked to #Parkinsons. Now researchers report that DSV-derived viability-dependent processes (including metabolic activity) more strongly promote alpha-synuclein aggregation & toxicity than structural component sciencedirect.com/science/ar…

Mission Therapeutics @MISSIONTherapeu announces dosing of first #Parkinsons patient in the Phase 1b study of their USP30 inhibitor MTX325. The study is taking place in UK, Europe & Australia. Readout is anticipated in late 2027 missiontherapeutics.com/miss…

Using large-scale hospital electronic health records of the University of California health system (n=890K hypertensive patients), researchers report Angiotensin receptor blockers irbesartan & olmesartan were associated with lower incident #Parkinsons risk onlinelibrary.wiley.com/doi/…

Something researchers to explore: The GBA1 Canada initiative (G-can) - a pre-competitive, collaborative, open-science platform accelerating research & treatment development for GBA1-related #Parkinsons journals.sagepub.com/doi/10.…

New research suggests dietary patterns/habits in isolated REM sleep behavior disorder is associated with gut microbiome dysbiosis & predicts neurodegenerative progression, highlighting diet–microbiome interactions as modifiable factors movementdisorders.onlinelibr…

Researchers virtually screen of 9.4k compounds (2.6k FDA-approved drugs, 6.7k African natural products) against the ATP-binding pocket of LRRK2-G2019S, & identify Rimonabant, Gallagic acid, Acalabrutinib, & Atovaquone as repurposable candidates nature.com/articles/s41598-0…

Researchers report a case of #Parkinsons caused by a de novo SNCA triplication with longitudinally evaluated gene expression in whole blood & platelets at 2 disease stages: early PD (age 41) & Parkinson's disease dementia (age 44) movementdisorders.onlinelibr…

New research from the GP2 team finds that the GCH1 p.Ser80Asn variant is a rare, East Asian-enriched risk variant for #Parkinsons movementdisorders.onlinelibr…

Another week, another paper for @GeorgeTofaris & colleagues This week, they report the epitope accessibility & topology of extracellular vesicle-associated α-synuclein proteoforms, rather than their abundance alone, discriminate synucleinopathy subtypes academic.oup.com/brain/advan…

New review explores resilience & vulnerability in the midbrain dopamine system during aging; "Elucidating these neuroadaptive mechanisms could offer a path toward preserving dopamine neuron function across the lifespan" & possibly preventing neurodegen. cell.com/trends/neuroscience…