Opinions are my own.
Buffalo, NY
Joined October 2018
- Tweets463
- Following398
- Followers596
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Mike Martynowycz retweeted
Another fantastic results published in #JACS. This work shows a great potential of #microED for studying mineralogical and geological samples. ED data were acquired on our Glacios at CeNT UW. pubs.acs.org/doi/full/10.102…
Mike Martynowycz retweeted
Congratulations to Judge Susan Crawford on her victory, and to the people of Wisconsin for electing a judge who believes in the rule of law and protecting our freedoms.
Mike Martynowycz retweeted
What holds your eye lens together? UCLA scientists along with now UB-HWI faculty found out! Using advanced microcrystal electron diffraction, they solved the structure of the abundant lens protein MP20. nature.com/articles/s41467-0…
Mike Martynowycz retweeted
Researchers from UCLA and UB-HWI have pushed the boundaries of electron crystallography, achieving sub-atomic resolution using energy-filtered #MicroED #CryoEM. This improves structural detail, advancing drug discovery and biomolecular research. nature.com/articles/s41467-0…
Mike Martynowycz retweeted
Now most folks cant tell the difference between an Xray diffraction pattern and #MicroED 😁
Behold 0.9Å 😍
Mike Martynowycz retweeted
Happy to share high throughput ligand and inhibitor screening against enzymes using MicroED. Drug discovery based on structures
Ligand Screening and Discovery using Cocktail Soaking and Automated MicroED | bioRxiv biorxiv.org/content/10.1101/…
Mike Martynowycz retweeted
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @CellCellPress cell.com/cell/fulltext/S0092… . What’s new?
Mike Martynowycz retweeted
Probing ion channel dynamics at atomic resolution using vanishingly small crystals and #MicroED.
Yes, dynamics can be probed even qith crystals...
High-throughput MicroED for probing ion channel dynamics | bioRxiv biorxiv.org/content/10.1101/…
Mike Martynowycz retweeted
Whats the best slit width for your energy filter? @maxclabbers systematically tested the settings. The results may surprise you...
Characterization of energy filtering slit widths for MicroED data collection | bioRxiv biorxiv.org/content/10.1101/…
Mike Martynowycz retweeted
The 7th Challenges in Structural Biology Summit will be 9/9-12/25 at UCLAs Lake Arrowhead Resort. @BrentNannenga and I are taking nominations for speakers. Please write, self nominations are OK. Focus is on methods and challenges. Everyone speaks. Limited to 50 speakers/attendees
Mike Martynowycz retweeted
#FeaturedProtocol this week from @gonenlab: The preparation of #microcrystals for #CryoEM enables the acquisition of diffraction patterns from nanometre-sized samples go.nature.com/4j47NcK See also accompanying News & Views
Mike Martynowycz retweeted
@WiwiSFC @maxclabbers @ScienceMick @calliesayshi @Anna_Shiriaeva_ cody gillman and many others that contributed over the years to this collective #cryoem #MicroED knowledge - now at your fingertips 😍
#FeaturedProtocol this week from @gonenlab: The preparation of #microcrystals for #CryoEM enables the acquisition of diffraction patterns from nanometre-sized samples go.nature.com/4j47NcK See also accompanying News & Views
Mike Martynowycz retweeted
🔬 Tiny crystals, big impact! Our new @NatureProtocols guide helps scientists unlock the secrets of molecules using #MicroED, a powerful #cryoEM technique. We explain how to prepare samples for this cutting-edge method. #StructuralBiology #ScienceProtocols doi.org/10.1038/s41596-024-0…
Mike Martynowycz retweeted
We are excited to share this comprehensive protocol for #cryoem #MicroED. This is everything you need to know for sample preparation for both small molecules and macromolecules including membrane proteins
nature.com/articles/s41596-0…
Mike Martynowycz retweeted
Glad this is finally out! A group effort of multiple generations of Gonen lab alumni! If you want a step by step guide on all the microED variants possible. This is your bus stop!
🎉🎉🎉 Happy to answer any questions also by email or DM :--)
nature.com/articles/s41596-0… – at San Francisco, CA
Mike Martynowycz retweeted
New discovery! Researchers from HWI, UCLA & HHMI use cutting-edge cryoET & cryoEM to uncover how viruses hijack the cell and assemble. This breakthrough in virus-host interactions could lead to new therapies & showcases HWI's structural biology merit. nature.com/articles/s41467-0…
Mike Martynowycz retweeted
Join Amgen Structural Biology in Thousand Oaks to do #cryoEM !
amgen.wd1.myworkdayjobs.com/…
Mike Martynowycz retweeted
#cryoEM with energy filter & electron counting significantly increased resolution even for a full size protein like proteinase K. Sub-atomic resolution #MicroED rivals best reported Xray of Proteinase K but by using crystals a billionth the size. A section of the map is shown
Mike Martynowycz retweeted
Excited to share our latest preprint @gonenlab @ScienceMick, where we demonstrate how an energy filter can significantly enhance macromolecular MicroED data quality - showing diffraction spots extending to ~1 Å resolution from proteinase K xtals: doi.org/10.1101/2024.08.29.6…
