@ScienceMick

Opinions are my own.

 Buffalo, NY
Joined October 2018
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  • Followers596
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Our work on ab initio phasing #MicroED data is now published @naturemethods! Big thanks to @markherzik @_KevinCorbett for writing an awesome News & Views (and Mark for reviewing the work). Big thanks to @gonenlab @maxclabbers and Johan for their hard work! nature.com/articles/s41592-0…
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I feel like @Apple knew their “doesn’t ring for unknown numbers” would make it impossible for these awful customer service callbacks to ever get ahold of you. @JetBlue should be embarrassed. Cancel a flight 2 hours before takeoff and won’t even answer the phone to rebook :-/
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👀 The Frontiers of Structure | Science | AAAS science.org/content/blog-pos…

The Frontiers of Structure

The Frontiers of Structure

science.org
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Mike Martynowycz retweeted
Tomasz Góral@t_goral18 Jul 2025
Another fantastic results published in #JACS. This work shows a great potential of #microED for studying mineralogical and geological samples. ED data were acquired on our Glacios at CeNT UW. pubs.acs.org/doi/full/10.102…

Symmetrization of Strong Hydrogen Bond under High Pressure in Bihydroxide-Ion-Containing NaCu2(SO...

Abstract. In minerals and inorganic compounds, strong hydrogen bonding can lead to the formation of complex ionic species such as the H3O2– bihydroxide ani

pubs.acs.org
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🍃➡️🧬 First paper from the Martynowycz Lab! Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias. Watch the diffraction-to-density movie & grab the preprint below! biorxiv.org/content/10.1101/…
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Coming soon! Deep dish Eucharist. #Chicago #Pope
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Mike Martynowycz retweeted
Barack Obama
@BarackObama2 Apr 2025
Congratulations to Judge Susan Crawford on her victory, and to the people of Wisconsin for electing a judge who believes in the rule of law and protecting our freedoms.
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What holds your eye lens together? UCLA scientists along with now UB-HWI faculty found out! Using advanced microcrystal electron diffraction, they solved the structure of the abundant lens protein MP20. nature.com/articles/s41467-0…

Structure of the lens MP20 mediated adhesive junction

Nature Communications - Human lens clarity and function depends on well-organized cell junctions. Here, the authors used MicroED to reveal the 3.5 Å structure of MP20, showing that MP20...

nature.com
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Mike Martynowycz retweeted
Tamir Gonen@gonenlab26 Mar 2025
Super stoked that this study is finally out Heroic effort from several people and of course #cryoem #MicroED #FIB 👍👍 Structure of the lens MP20 mediated adhesive junction | Nature Communications nature.com/articles/s41467-0…

Structure of the lens MP20 mediated adhesive junction

Nature Communications - Human lens clarity and function depends on well-organized cell junctions. Here, the authors used MicroED to reveal the 3.5 Å structure of MP20, showing that MP20...

nature.com
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Researchers from UCLA and UB-HWI have pushed the boundaries of electron crystallography, achieving sub-atomic resolution using energy-filtered #MicroED #CryoEM. This improves structural detail, advancing drug discovery and biomolecular research. nature.com/articles/s41467-0…
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Mike Martynowycz retweeted
Tamir Gonen@gonenlab6 Mar 2025
Now most folks cant tell the difference between an Xray diffraction pattern and #MicroED 😁 Behold 0.9Å 😍
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Our latest work shows how energy filtering, PFIB, and direct electron detection unlock sub-atomic resolution for #MicroED! 🎯 Great work from @maxclabbers and JohanHattne back when I was with @gonenlab at @BC_UCLA. Excited to bring this capability to @UBuffalo!
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Mike Martynowycz retweeted
Tamir Gonen@gonenlab4 Mar 2025
Happy to share high throughput ligand and inhibitor screening against enzymes using MicroED. Drug discovery based on structures Ligand Screening and Discovery using Cocktail Soaking and Automated MicroED | bioRxiv biorxiv.org/content/10.1101/…

Ligand Screening and Discovery using Cocktail Soaking and Automated MicroED

Cocktail soaking using single-crystal X-ray diffraction (SC-XRD) has previously allowed high-throughput crystallographic screening of ligands against protein targets. However, protein microcrystals...

biorxiv.org
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Mike Martynowycz retweeted
Sven Klumpe@svenklumpe5 Mar 2025
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @CellCellPress cell.com/cell/fulltext/S0092… . What’s new?
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Mike Martynowycz retweeted
Tamir Gonen@gonenlab4 Mar 2025
Probing ion channel dynamics at atomic resolution using vanishingly small crystals and #MicroED. Yes, dynamics can be probed even qith crystals... High-throughput MicroED for probing ion channel dynamics | bioRxiv biorxiv.org/content/10.1101/…

High-throughput MicroED for probing ion channel dynamics

Ion channels play a crucial role in ion transport and are integral to fundamental physiological processes. Therefore, understanding channel structures is essential for elucidating the mechanisms of...

biorxiv.org
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Mike Martynowycz retweeted
Tamir Gonen@gonenlab4 Mar 2025
Whats the best slit width for your energy filter? ⁦@maxclabbers⁩ systematically tested the settings. The results may surprise you... Characterization of energy filtering slit widths for MicroED data collection | bioRxiv biorxiv.org/content/10.1101/…

Characterization of energy filtering slit widths for MicroED data collection

A favorable signal-to-noise ratio is essential for obtaining high-quality diffraction data in macromolecular electron crystallography. Inelastic scattering contributes significantly to the noise,...

biorxiv.org
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Mike Martynowycz retweeted
Tamir Gonen@gonenlab19 Jan 2025
The 7th Challenges in Structural Biology Summit will be 9/9-12/25 at UCLAs Lake Arrowhead Resort. @BrentNannenga and I are taking nominations for speakers. Please write, self nominations are OK. Focus is on methods and challenges. Everyone speaks. Limited to 50 speakers/attendees
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I’m happy to share that @HWMRI has merged with @UBuffalo. My lab will stay at HWI, and my title is changing. I’m starting a new position as a tenure track Assistant Professor at the Jacob’s School of Medicine at the University at Buffalo!
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#FeaturedProtocol this week from @gonenlab: The preparation of #microcrystals for #CryoEM enables the acquisition of diffraction patterns from nanometre-sized samples go.nature.com/4j47NcK See also accompanying News & Views
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