Scientist | Ph.D. candidate @GSBS_UMassMed in Kim lab, Cancer Biology Program | Alum @Northeastern
Boston, MA
Joined April 2013
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Mihir B. Doshi retweeted
Our paper has been published today in Nature Metabolism! I extend my sincere thanks to all authors: @SungJin2619, @MikeLangePhD , T. Tseyang, @ScienceGraduate, T.Y. Kim, Y. Song, D.I. Kim, @Greer_Lab , @OlzmannLab , @JBSpinelli , and Dohoon Kim.
nature.com/articles/s42255-0…
Mihir B. Doshi retweeted
“It’s like clogging a drain.” Dohoon Kim, PhD, & colleagues have found a way to poison cancer cells with their waste: direc.to/khqL
As published in @Nature. #LungCancer @UMassChanMCCB @UMassCancerCtr @ScienceGraduate @JBSpinelli @KarlSimin @lab_mercurio @MarianWalhout
It is also theoretically possible that aberrant UGT mediates aberrant glucuronidations contributing to toxicity but we did not see any evidence. 2/2
Hi Hiren, that is an excellent point. Regarding UGTs, we've thought about them but have not looked extensively. They do not seem to comprise a significant 'sink' that consumes the aberrant accumulation of UDPGA. 1/2
I'm incredibly thrilled to announce my first-author publication in @Nature . I would like to thank all my collaborators and specially @NamgyuLee1 , @chrashwood , @KarlSimin , @cholsoon_jang , @lab_mercurio , @MarianWalhout, @JBSpinelli my PI and Dohoon Kim.
Mihir B. Doshi retweeted
The Senate passed the Sunshine Protection Act which would make daylight saving time permanent across the U.S. beginning in 2023. n.pr/3u0QWir
Mihir B. Doshi retweeted
.@eric_lander says he’s seen the U.S. take on “amazing challenges” to make the world a better place. Now, he says, “the opportunities we have and the challenges we face are greater than ever before” cbsn.ws/2KjDqUa
Mihir B. Doshi retweeted
“It's the gaps, stupid!" Despite the dogma police, we’re not completely broken, just like the DNA: a new model for BRCAness tinyurl.com/BRCAness from phenom student Nick Panzarino in Cantor Lab.tinyurl.com/Cantorlab
Mihir B. Doshi retweeted
BREAKING NEWS:
The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
Mihir B. Doshi retweeted
Hello SciTwitter, I am proud to share ANOTHER paper out of the Kim Lab today-this time a great review written by my good friends and lab mates @NamgyuLee1 and Meghan, and myself in a supporting role, and advised by Do. Congrats again Kim Lab!🎉 Read here: rdcu.be/b5PaO
Selenium metabolism protects them against ferroptotic insults, but a toxic intermediate formed in this process can be exploited to poison them. Congratulations co-first authors
@A_Carlisle_19 , Namgyu Lee and Kim lab.
@NatMetabolism
Read here: rdcu.be/b5r2w (2/2)
Selenium is a micronutrient that is incorporated into selenoproteins via the selenocysteine biosynthesis pathway. The authors describe a two-faced role for selenium in cancer cells (1/2)
Mihir B. Doshi retweeted
Online now! A micronutrient with major effects on cancer cell viability dlvr.it/Rb482k
Mihir B. Doshi retweeted
Today I celebrate the publication of the research paper I have worked hard to develop for the past 4 years. Next up, thesis defense- PhD here I come! Most importantly: I could not have done this without my family, friends, and lab mates. Congratulations, Kim Lab! 🎉🎉🎉
Mihir B. Doshi retweeted
🚨BREAKING: preliminary data from an ongoing clinical study of #remdesivir showed that in 113 patients with severe #COVID19:
▶️Fever/symptoms rapidly improved
▶️Most discharged within 6 days
▶️2 died (1.8%), much less than expected for severe #COVID19
statnews.com/2020/04/16/earl…
Mihir B. Doshi retweeted
As expected, data emerges to explain observations of #COVID19 “reinfection”—here, most patients who were ”redetected positive” were actually never truly negative. Plus reinfection cannot be rampant if family members living together successively infect each other but all recover.
#COVID19 Important new preprint on heatedly debated "re-infection", or more accurately "re-detectable positive" patients
medrxiv.org/content/10.1101/…
18/24 of RNA-negative samples tested to be positive using a hyper-sensitive method, support the notion that many RP are false negative
