@LazarusLab

Crystallography and Chemical Biology Lab

 Mount Sinai
lazaruslab.org
Joined September 2017
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Excited to share our first cryo-EM paper, which was just published in Nucleic Acids Research: academic.oup.com/nar/advance… We investigate a new family of RNases with crystal and cryo-EM structures. Congrats Ruoxi!

Structural insights into RNA cleavage by a novel family of bacterial RNases

Abstract. Processing of RNA is a key regulatory mechanism for all living systems. Escherichia coli protein YicC belongs to the well-conserved YicC family a

academic.oup.com
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Our new paper on SUGCT is out, in collaboration with the Houten Lab. Congrats Ruoxi and Susmita! pubs.acs.org/doi/10.1021/acs…

Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a...

Abstract. Glutaric Aciduria Type 1 (GA1) is a serious inborn error of metabolism with no pharmacological treatments. A novel strategy to treat this disease

pubs.acs.org
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We're now on Post! post.news/michaellazarus
Excited to share our new paper on autophagy and cancer: pubs.acs.org/doi/10.1021/acs… Congrats Kisa, Agata, and Carisse! We found a new link between autophagy inhibition and the cell cycle. Also we show that many autophagy inhibitors are dirty. Be careful!

Selective Inhibitors of Autophagy Reveal New Link between the Cell Cycle and Autophagy and Lead to...

Abstract. Autophagy is a conserved metabolic pathway that is central to many diseases. Recently, there has been a lot of interest in targeting autophagy wi

pubs.acs.org
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Excited for our latest paper: royalsocietypublishing.org/d… A collaboration with @SanderHouten and DeVita Labs at Mount Sinai. The first structure of an interesting metabolic enzyme and a curious case of allostery. Stay tuned for more on this project! Congrats to everyone involved!

Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel...

Abstract.

royalsocietypublishing.org
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Congrats @KupfermanTania and the NYU team on the convalescent plasma study for COVID-19
Mila B. Ortigoza, MD, PhD@MBOrtigoza
13 Dec 2021
Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients ja.ma/3pMSPx4 via @JAMAInternalMed part of @JAMANetwork
Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients ja.ma/3pMSPx4 via @JAMAInternalMed part of @JAMANetwork
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Excited to be part of #Target2035 today!
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The Lazarus Lab is hiring! We're looking for a postdoc to work on our NIH-funded Alzheimer's project. Neuronal cell culture and autophagy experience are a plus! #drugdesign For more info and to apply, go here: careers.mountsinai.org/jobs/… @IcahnMountSinai @SfNtweets
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I have a protein crystallography joke for you, but I think it may be salty.
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Our team's new paper and new structure of DHTKD1 is out in ACS Chem Bio, led by the lab of @SanderHouten and our collaborators at Mount Sinai, UCSF, and Rutgers. pubs.acs.org/doi/10.1021/acs…

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

Abstract. DHTKD1 is the E1 component of the 2-oxoadipate dehydrogenase complex, which is an enzyme involved in the catabolism of (hydroxy-)­lysine and tryp

pubs.acs.org
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Proud of this new paper led by Michael Lazarus @LazarusLab on the structural characterization of the schizophrenia-linked pseudokinase ULK4. A really intriguing protein. pubs.acs.org/doi/full/10.102…

High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4

Abstract. The ULK (UNC51-like) enzymes are a family of mammalian kinases that have critical roles in autophagy and development. While ULK1, ULK2, and ULK3

pubs.acs.org
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The first paper of the Lazarus Lab is out! pubs.acs.org/doi/abs/10.1021… We solved the first structure of a cool pseudokinase that is implicated in schizophrenia

High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4

Abstract. The ULK (UNC51-like) enzymes are a family of mammalian kinases that have critical roles in autophagy and development. While ULK1, ULK2, and ULK3

pubs.acs.org
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