Postdoc in the @FritzLaylin lab. Fascinated by obscure protists. Evolutionary Cell Bio research via amoebae, cytoskeleton & diverse morphology. she/her.
Amherst, MA
Joined July 2018
- Tweets244
- Following483
- Followers387
- Likes1.8K
Sarah Guest retweeted
Plant developmental genes share functions & expression, but align orthologs' promoters and often… no conservation. Or is there?
In our new preprint, we show that conservation exists and is ancient, but was just obscured by genome complexity.
biorxiv.org/content/10.1101/…
Sarah Guest retweeted
.@fluoroforce, @pwoakes @myosincity et al. demonstrate subcellular biophysical mechanisms that enable #myosin 2 filament assembly. hubs.la/Q02_5lWN0
Part of the Year in Cell Biology: hubs.la/Q02_5CFd0
#CellBio2024
Sarah Guest retweeted
If you like Wallace's tweetorial and are going to ASCB, look out for my talk Tues. Dec 17th on how the microtubule cytoskeleton dictates RNA regionalization in Stentor!
#cellbio2024 #stentor #protist #NIHMOSAIC
Where does pattern come from inside cells? in this revised preprint, @aralbright93 shows that regionalization of mRNA in a Stentor cell depends on dynein motors and the microtubule cytoskeleton
doi.org/10.1101/2023.01.09.5…
Sarah Guest retweeted
Happy Halloween!
For night 31 of #31NightsOfHalloween #Microscreepy, here is a grand finale video!
Sarah Guest retweeted
For night 28 of #31NightsOfHalloween #MicrosCreepy,
IT'S ALIVE! These are reanimated cell "ghosts," which are cells that have had their membranes/cytoplasm washed away, leaving the cytoskeleton behind. Adding ATP activates myosin motors, which causes contraction!
Sarah Guest retweeted
For night 23 of #31nightsofhalloween #MicrosCreepy,
here’s a blebby amoeba! I overlaid several frames of a movie into the same image, so you can see the motion of the cell (inverted phase contrast) and its mitochondria (purple/pink/yellow).
Sarah Guest retweeted
Excited to announce that our 2025 Advanced Research Training Course schedule is up and applications are open! 🎉🎉🎉
See you in Woods Hole! mbl.edu/courses
ALT a list of all the 2025 Marine Biological Laboratory Advanced Research Training Courses with course dates and application deadlines listed.
Sarah Guest retweeted
For night 19 of #31NightsOfHalloween #MicrosCreepy, here are some amoebae huddling together. The blinking you’re seeing is the contractile vacuole filling and emptying—this is how many pond-dwelling protists deal with fresh water rushing through the membrane due to osmosis.
Sarah Guest retweeted
We were fortunate to have @Sarahmoeba leading Microscopy Monday yesterday! She gave a talk on original microscopy techniques used for evolutionary significant but understudied protists. 🦠🔬💚
#Microscopy_Monday_Howard_University
Sarah Guest retweeted
First molecular data on Pocheina (Acrasidae, Heterolobosea). This paper represents a very long journey, starting with a mistake I made as a PhD student.
biorxiv.org/content/10.1101/…
Sarah Guest retweeted
For night 6 of #31NightsofHalloween #MicrosCreepy,
here’s a monster of an amoeba with 6 nuclei!
Sarah Guest retweeted
For night 3 of #31NightsofHalloween #MicrosCreepy, here are some cells spilling their guts
Sarah Guest retweeted
For night 4 of #31NightsofHalloween #MicrosCreepy, here is a scary alien! Or, an amoeba imaged by Scanning Electron Microscreepy.
Sarah Guest retweeted
For night 2 of #31NightsofHalloween #MicrosCreepy, here is a video of amoebae crawling on a glass coverslip. These cells were imaged by IRM, which shows only the area of the cell in closest contact with the coverslip (like footprints!)
Sarah Guest retweeted
It’s that time of year again— #31NightsofHalloween #MicrosCreepy!
For night 1, here are some amoebae stained for actin polymer 🧡
Sarah Guest retweeted
Cell 1: I am going this way.
Cell 2: No, come this way with me.
Cell 1: Where are we going?
Cell 2: No clue, but at least we will be together.
Some that wander are lost........
#CellBiology
Sarah Guest retweeted
#Parabasilds are pretty funky #Protists.
Did anyone ever manage to visualize #Actin in any of these termite-parasite?
#UExM
Sarah Guest retweeted
📢We are hiring a microscope specialist! Please apply and/or spread the word! hhmi.wd1.myworkdayjobs.com/e…
Sarah Guest retweeted
In their #OpenAccess Review, @KatrinaVelle @UMassD, @Swafford_AJ, @fleshball and @fritzlaylin @UMassAmherst discuss actin network evolution as a key driver of eukaryotic diversification.
journals.biologists.com/jcs/…
ALT Diagram showing i) the major steps of actin regulation: nucleation, elongation and disassembly, ii) the different actin networks (dynamic actin polymers, stabilised actin polymers, expansive actin networks and contractile actin networks) and iii) the cellular processes that are regulated (cell shape and migration, cytoplasmic streaming and cell division).
