@Sarahmoeba

Postdoc in the @FritzLaylin lab. Fascinated by obscure protists. Evolutionary Cell Bio research via amoebae, cytoskeleton & diverse morphology. she/her.

 Amherst, MA
Joined July 2018
  • Tweets244
  • Following483
  • Followers387
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Our work on Naegleria Myosin 2 is out! Naegleria encodes 3 Myo2s, which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea. Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling. cell.com/current-biology/ful…

Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage

Myosin 2-dependent actin contractility—the force that powers cell division and migration in animals, fungi, and other Amorphea—had been previously unknown outside this single eukaryotic group. Guest...

cell.com
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Sarah Guest retweeted
Idan Efroni@efronilab19 Sep 2025
Plant developmental genes share functions & expression, but align orthologs' promoters and often… no conservation. Or is there? In our new preprint, we show that conservation exists and is ancient, but was just obscured by genome complexity. biorxiv.org/content/10.1101/…

A deep-time landscape of plant cis-regulatory sequence evolution

Developmental gene function is conserved over deep time, but cis -regulatory sequence conservation is rarely found. Rapid sequence turnover, paleopolyploidy, structural variation, and limited...

biorxiv.org
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.@fluoroforce, @pwoakes @myosincity et al. demonstrate subcellular biophysical mechanisms that enable #myosin 2 filament assembly. hubs.la/Q02_5lWN0 Part of the Year in Cell Biology: hubs.la/Q02_5CFd0 #CellBio2024
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If you like Wallace's tweetorial and are going to ASCB, look out for my talk Tues. Dec 17th on how the microtubule cytoskeleton dictates RNA regionalization in Stentor! #cellbio2024 #stentor #protist #NIHMOSAIC
Wallace Marshall@WallaceUcsf2 Dec 2024
Where does pattern come from inside cells? in this revised preprint, @aralbright93 shows that regionalization of mRNA in a Stentor cell depends on dynein motors and the microtubule cytoskeleton doi.org/10.1101/2023.01.09.5…
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Happy Halloween! For night 31 of #31NightsOfHalloween #Microscreepy, here is a grand finale video!
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For night 28 of #31NightsOfHalloween #MicrosCreepy, IT'S ALIVE! These are reanimated cell "ghosts," which are cells that have had their membranes/cytoplasm washed away, leaving the cytoskeleton behind. Adding ATP activates myosin motors, which causes contraction!
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For night 23 of #31nightsofhalloween #MicrosCreepy, here’s a blebby amoeba! I overlaid several frames of a movie into the same image, so you can see the motion of the cell (inverted phase contrast) and its mitochondria (purple/pink/yellow).
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Excited to announce that our 2025 Advanced Research Training Course schedule is up and applications are open! 🎉🎉🎉 See you in Woods Hole! mbl.edu/courses
a list of all the 2025 Marine Biological Laboratory Advanced Research Training Courses with course dates and application deadlines listed.

ALT a list of all the 2025 Marine Biological Laboratory Advanced Research Training Courses with course dates and application deadlines listed.

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For night 19 of #31NightsOfHalloween #MicrosCreepy, here are some amoebae huddling together. The blinking you’re seeing is the contractile vacuole filling and emptying—this is how many pond-dwelling protists deal with fresh water rushing through the membrane due to osmosis.
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We were fortunate to have @Sarahmoeba leading Microscopy Monday yesterday! She gave a talk on original microscopy techniques used for evolutionary significant but understudied protists. 🦠🔬💚 #Microscopy_Monday_Howard_University
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First molecular data on Pocheina (Acrasidae, Heterolobosea). This paper represents a very long journey, starting with a mistake I made as a PhD student. biorxiv.org/content/10.1101/…
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For night 6 of #31NightsofHalloween #MicrosCreepy, here’s a monster of an amoeba with 6 nuclei!
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For night 3 of #31NightsofHalloween #MicrosCreepy, here are some cells spilling their guts
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For night 4 of #31NightsofHalloween #MicrosCreepy, here is a scary alien! Or, an amoeba imaged by Scanning Electron Microscreepy.
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Not pictured, the timestamps showing how long I waited between each message.
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For night 2 of #31NightsofHalloween #MicrosCreepy, here is a video of amoebae crawling on a glass coverslip. These cells were imaged by IRM, which shows only the area of the cell in closest contact with the coverslip (like footprints!)
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It’s that time of year again— #31NightsofHalloween #MicrosCreepy! For night 1, here are some amoebae stained for actin polymer 🧡
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Happy Friday! I hope you get a chance to go on a little adventure this weekend, like these exploring amoebae carving trails in their bacteria lawn.
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Sarah Guest retweeted
Dylan Burnette
@MAG2ART25 Aug 2024
Cell 1: I am going this way. Cell 2: No, come this way with me. Cell 1: Where are we going? Cell 2: No clue, but at least we will be together. Some that wander are lost........ #CellBiology
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