@SarahAlamdari

Interested in all things deep learning, biology, and molecular dynamics. @MSRNE #diversity & #representation matter (she/her)

 Cambridge, MA
sarahalamdari.com
Joined April 2019
  • Tweets1.3K
  • Following1K
  • Followers1.6K
76Media
Deep sea gene editor is crazy
Ceron Lab@CeronLabOct 18
🧬🌊 New preprint from our lab: DO1 Cas9, the first Cas9 nuclease characterised from the deep ocean — recovered from a metagenome at 1,500 m in the Atlantic. ❄️Cold-adapted: it cuts DNA efficiently at low temperature, where mesophilic SpCas9 retains only residual activity. 🧵1/4
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Noelia Ferruz@ferruz_noelia3h
Continuing with with early life origins, Weiss et al. analyzed 6.1 million genes and found 355 protein families likely present in the last common universal ancestor, suggesting it was anaerobic, CO2-fixing, H2-dependent, N2-fixing, and thermophilic: nature.com/articles/nmicrobi…

The physiology and habitat of the last universal common ancestor

Nature Microbiology - A phylogenetic approach was used to illuminate the physiology of the last universal common ancestor, supporting the theory that LUCA was an H2-dependent autotroph in a...

nature.com
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Ceron Lab@CeronLabOct 18
🧬🌊 New preprint from our lab: DO1 Cas9, the first Cas9 nuclease characterised from the deep ocean — recovered from a metagenome at 1,500 m in the Atlantic. ❄️Cold-adapted: it cuts DNA efficiently at low temperature, where mesophilic SpCas9 retains only residual activity. 🧵1/4
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Magnus Bauer@kinasekidOct 18
Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇 nature.com/articles/s41586-0…
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Rohith Krishna@r_krishna3Oct 15
Today we're sharing an update on our diffusion method from last year, RFdiffusion3, in @ScienceMagazine. Notably, we show significant improvement in design of sequence specific proteases for amyloid sequences and metallohydrolases for pesticide degradation.
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Jasper Butcher@butcher_jasperOct 15
Today, RFdiffusion3 is out in @ScienceMagazine! science.org/doi/10.1126/scie… We have many exciting updates to share! We're also releasing Chaperone, an agent harness for general bio-molecular design. 1/n
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Calling graduate students 📣. Come work on AI x Bio @MSFTResearch 🎉! We are currently recruiting graduate student interns for summer 2027! Apply and come work with me on problems in regulatory genomics, epigenomics, biosecurity, and wearables!
Kevin K. Yang 楊凱筌@KevinKaichuangOct 14
Are you a PhD student interested in the intersection of machine learning and biology or healthcare? Come do an internship with the BioML Group at MSR! Make sure you submit a research statement! apply.careers.microsoft.com/…
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Nicolò Fusi
@nfusiOct 15
Yes they are!
Nil Adell Mill@fluck_5Oct 14
Absolutely cracked team and opportunity to intern at!👇
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Nil Adell Mill@fluck_5Oct 14
Absolutely cracked team and opportunity to intern at!👇
Kevin K. Yang 楊凱筌@KevinKaichuangOct 14
Are you a PhD student interested in the intersection of machine learning and biology or healthcare? Come do an internship with the BioML Group at MSR! Make sure you submit a research statement! apply.careers.microsoft.com/…
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Kieran Didi@DidiKieranOct 14
Very fortunate to have contributed a bit to these two new Nature papers from the Baker lab! Especially exciting cool to see that MLIPs hold signal for this cool chemistry. Stay tuned for more! Metalloproteases: nature.com/articles/s41586-0… Cysteine Proteases: nature.com/articles/s41586-0…

Computational design of metalloproteases

Nature - RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable...

nature.com
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Emma J Chory@choryeOct 14
I had a chance to present at the tail end of the BioML Symposium this summer and was blown away by the work and progress of the students! Also a great opportunity to work with amazing mentors like @KevinKaichuang @SarahAlamdari @AshleyMaeConard and the rest of the BioML team. Highly recommend for PhD students nearing graduation who are interested in exploring industry research careers!
Kevin K. Yang 楊凱筌@KevinKaichuangOct 14
Are you a PhD student interested in the intersection of machine learning and biology or healthcare? Come do an internship with the BioML Group at MSR! Make sure you submit a research statement! apply.careers.microsoft.com/…
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Christian Dallago@sacdallagoOct 14
The 2027/2028 NVIDIA Graduate Fellowship is open! PhD students can receive up to $60,000, plus a summer internship with NVIDIA. I want to especially encourage life science students to apply! Applications and recommendation letters are due October 30. research.nvidia.com/graduate…
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We're hiring research interns in machine learning, generative modeling, and their applications! Our research scope is broad, so if you're interested, feel free to reach out and tell us a bit about your research interests! Apply here: apply.careers.microsoft.com/…

Research Intern - Machine Learning and Statistics | Microsoft Careers

Research Interns put inquiry and theory into practice. Alongside fellow doctoral candidates and some of the world's best researchers, Research Interns learn, collaborate, and network for life....

apply.careers.microsoft.com
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Yuanqi Du
@YuanqiDOct 14
We are hiring research interns in the broad area of machine learning and statistics @MSRNE @MSFTResearch! Come work with us! Personally I have very broad interests and I’d love to learn about your favorite problems!
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Lester Mackey@LesterMackeyOct 14
Led by former @MSFTResearch interns Hannah Guan and Soukayna Mouatadid, with Paulo Orenstein, @judah47, Haiyu Dong, Zekun Ni, Jeremy Berman, @GFlaspohler, @alexijielu, Jakob Schloer, Joshua Talib, Jonathan A. Weyn Read the #OpenAccess paper in @Nature: nature.com/articles/s41586-0…

Advancing subseasonal forecasting with machine learning

Nature - The AI framework probabilistic bias correction is shown to correct weather forecast errors 2 to 6 weeks ahead and boost forecast skill, making it promising for improved...

nature.com
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Are you a PhD student interested in the intersection of machine learning and biology or healthcare? Come do an internship with the BioML Group at MSR! Make sure you submit a research statement! apply.careers.microsoft.com/…
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I'm recruiting PhD interns for Summer 2027! If you’re excited about using generative protein language models to tackle real functional protein problems, please apply here!
Kevin K. Yang 楊凱筌@KevinKaichuangOct 14
Are you a PhD student interested in the intersection of machine learning and biology or healthcare? Come do an internship with the BioML Group at MSR! Make sure you submit a research statement! apply.careers.microsoft.com/…
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Pranam Chatterjee
@pranamanamOct 2
For biomolecules, smaller is better: easier to synthesize, manufacture & deliver. 💊 The challenge is shrinking a molecule while retaining/improving what makes it work. 🤏 In our newly-accepted @NeurIPSConf paper, we introduce pCoMole to do this!! 🥑 📜: arxiv.org/abs/2610.01663 🤗: huggingface.co/ChatterjeeLab…
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Garyk Brixi
@garykbrixiSep 22
Genomes are full of dark matter of unknown functions. We present Minerva, a new method for discovery guided by genome language models. Minerva reveals the interactions hidden in non-coding DNA, pointing to hundreds of new putative RNAs and repetitive elements per bacterial genome. Minerva allows us to find and study elements invisible to traditional methods at orders of magnitude greater scale than before.
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Yunha Hwang
@Micro_YunhaSep 18
Can genomic language models design biological systems to access new regions of chemical space? Some of the most complex molecules in nature are made by biosynthetic gene clusters: massive enzymes that carry out complex chemistry. But engineering these systems is challenging due to complex cross-domain interactions. To solve this, we applied gLM2 to controllably generate new domain architectures by learning from vast evolutionary data.
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