@SAGA_Complex

Multiprotein complex. About 1.6 MDa and 28x20 nm. Conserved in eukaryotes. Multifunctional. Transcriptional regulator.

 Eukaryotes
Joined October 2018
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  • Followers166
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The SAGA complex is now on Twitter!
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Look at me, I made it to the cover! 😊🥰
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In this Review, Soffers and Workman discuss the initial discovery of the canonical SAGA complex, the subsequent studies that have shaped our view, and the latest structural work that provides insights into its function. @jerryleeworkman @ScienceStowers genesdev.cshlp.org/content/3…
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Check out this most recent review on my structure and function, from Jelly Soffers and @jerryleeworkman and published in @GenesDev 23 years since my discovery and we keep learning! genesdev.cshlp.org.insb.bib.…
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The Novel ReNu Region of TAF12 Regulates Gcn5 Nucleosomal Acetylation pubmed.ncbi.nlm.nih.gov/3283…

The Novel ReNu Region of TAF12 Regulates Gcn5 Nucleosomal Acetylation - PubMed

The post-translational acetylation of the histone components of chromatin mediates numerous DNA-templated events, including transcriptional activation, DNA repair, and genomic replication. The...

pubmed.ncbi.nlm.nih.gov
Architecture of the multi-functional SAGA complex and the molecular mechanism of holding TBP pubmed.ncbi.nlm.nih.gov/3294…

Architecture of the multi-functional SAGA complex and the molecular mechanism of holding TBP -...

In eukaryotes, transcription of protein encoding genes is initiated by the controlled deposition of the TATA-box binding protein TBP onto gene promoters, followed by the ordered assembly of a...

pubmed.ncbi.nlm.nih.gov
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Review by Sharon Dent and colleagues @EKoutelou on the complex functions of Gcn5 and Pcaf in development and disease sciencedirect.com/science/ar…
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Review by Vikki Weake and colleagues on the Gcn5 complexes in Drosophila as a model for metazoa sciencedirect.com/science/ar…
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Review by @susaopina an colleagues on the promiscuity of my subunits: Multifunctional or moonlighting? sciencedirect.com/science/ar…
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My "fathers", James Brownell and David Allis at @RockefellerUniv , review the discovery of my HAT: Heading toward an elusive goal with a key biological assist sciencedirect.com/science/ar…
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Review by @DowneyUOttawa on non-histone protein acetylation by the evolutionarily conserved GCN5 and PCAF acetyltransferases sciencedirect.com/science/ar…
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SAGA and TFIID: Friends of TBP drifting apart. sciencedirect.com/science/ar…
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The SAGA continues: The rise of cis- and trans-histone crosstalk pathways sciencedirect.com/science/ar…
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SAGA_COMPLEX retweeted
MED_COMPLEX@MED_COMPLEX17 Jul 2020
Nucleolar Pol II !!!! nature.com/articles/s41586-0…

Nucleolar RNA polymerase II drives ribosome biogenesis

Nature - RNA polymerase II has an unexpected function in the nucleolus, helping to drive the expression of ribosomal RNA and to protect nucleolar structure through a mechanism involving triplex...

nature.com
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SAGA and TFIID: Friends of TBP drifting apart pubmed.ncbi.nlm.nih.gov/3267…

SAGA and TFIID: Friends of TBP drifting apart - PubMed

Transcription initiation constitutes a major checkpoint in gene regulation across all living organisms. Control of chromatin function is tightly linked to this checkpoint, which is best illustrated...

pubmed.ncbi.nlm.nih.gov
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The SAGA continues: The rise of cis- and trans-histone crosstalk pathways. ncbi.nlm.nih.gov/pubmed/3264… #pubmedsearches #feedly
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The yeast exoribonuclease Xrn1 and associated factors modulate RNA polymerase II processivity in 5’ and 3’ gene regions jbc.org/cgi/content/long/RA1…
Dynamic modules of the coactivator SAGA in eukaryotic transcription. ncbi.nlm.nih.gov/pubmed/3261…

Dynamic modules of the coactivator SAGA in eukaryotic transcription - PubMed

SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved transcriptional coactivator that consists of four functionally independent modules. Its two distinct enzymatic activities, histone acetyl...

pubmed.ncbi.nlm.nih.gov
SAGA Structures Provide Mechanistic Models for Gene Activation pubmed.ncbi.nlm.nih.gov/3253…

SAGA Structures Provide Mechanistic Models for Gene Activation - PubMed

Two recent reports by Cramer and Ben-Shem and colleagues present high-resolution structures of the yeast SAGA transcription coactivator complex. These are the first to resolve the stoichiometry and...

pubmed.ncbi.nlm.nih.gov
This CRISPR screen identifies my DUB activity as an important regulator of regulatory T cells, via stabilization of the Fox3p transcription factor. disq.us/t/3o9x9ts
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GCN5 acetylation is required for craniofacial chondrocyte maturation. ncbi.nlm.nih.gov/pubmed/3244…
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