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Eighteen suicides because of PSSD in the last two years. Many of them young people in their teens, 20's, and 30's.
How many more people have to lose their lives, before the world wakes up to the reality of this condition!
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Will anyone acknowledge the developmental impact of #PSSD?
It's not simply an annoying side effect. It's a disruption to an entire lifetime of emotional, sexual, psychological and social development.
Do any psychologists recognise this? I'm not a psychologist, but I find it impossible not to see something so clear.
Can anybody see how profound this really is or am I on my own? This isn't rhetorical. I'm genuinely asking and completely disillusioned.
Is it not really obvious that if you give a pill that stops you from experiencing emotions and sexuality to a young person - even if that's temporary - that it's going to have massive life consequences? Can anybody see that?
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After reviewing the evidence, the UK’s medicines regulator, the MHRA, has decided to explicitly recognise Post-SSRI Sexual Dysfunction (PSSD) in patient information leaflets.
It is becoming increasingly untenable to deny that PSSD is a real condition, or to dismiss the serious and potentially long-lasting harms associated with antidepressant use.
A special thanks to the patients and their families whose tireless advocacy helped make this happen.
The MHRA is introducing a series of new measures to strengthen how risks associated with antidepressant medicines are communicated to patients, carers and healthcare professionals. Read the full drug safety update here: brnw.ch/21x6qlr
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How long has it taken?!
Yes it’s a positive step but for all those affected and more importantly not warned! #PSSD
The MHRA is introducing a series of new measures to strengthen how risks associated with antidepressant medicines are communicated to patients, carers and healthcare professionals. Read the full drug safety update here: brnw.ch/21x6qlr
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The new MHRA safeguards for antidepressant prescription are a big step in the right direction. Glad to see them mention PSSD directly. Congratulations to UK PSSD advocates including @KatieRColl and ally @yassie_pirani for this victory.
The MHRA is introducing a series of new measures to strengthen how risks associated with antidepressant medicines are communicated to patients, carers and healthcare professionals. Read the full drug safety update here: brnw.ch/21x6qlr
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Antidepressants ruined my sex life... and I'm still suffering the side effects nearly 15 years later. Now I realise I didn't need the pills to begin with. You must think before taking these drugs trib.al/Cy6zLRo
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When Lauren Friedman showed up at Amherst College, she was surprised to discover that almost every single girl in her dorm and on her athletic team was already taking SSRIs.
Inside jokes about Zoloft & Lexapro were common on campus, and everyone seemed deeply grateful their persistent anxiety and depression from teenage years was magically disappearing from a pharmaceutical drug.
Like her peers, @lololizzle had struggled earlier in life with both anxiety and depression -- so Zoloft seemed like a perfect solution. After all, all of her friends were taking it too, so how bad could it be?
Little did she know, SSRIs are causing a silent epidemic among Gen Zers called Post-SSRI Sexual Dysfunction, or PSSD. Like untold tens of thousands of other people just like her, Lauren now has completely lost her libido, sensation in her genitals, and even a sense of emotional connection with the people around her... PERMANENTLY.
She says she and others like her were NEVER given informed consent about the risk of developing PSSD, and American doctors will rarely even diagnose the condition at all.
Whether it's birth control being thrown in the faces of teenage girls to magically "regulate your hormones" or Zoloft instantly prescribed to "make you happy," one thing is clear--the young women of Generation Z are being poisoned en masse without any understanding of what may happen to them down the line.
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After being rapidly tapered off 150mg of sertraline following 14 years of use, this is what I faced from GPs and psychiatrists. Most of them initially refused to acknowledge antidepressant withdrawal, repeatedly misdiagnosed me and through their responses, caused significantly more harm. I am one of thousands, probably significantly more, with a similar story.
GP 1: After fast sertraline taper (four weeks) and in delayed onset withdrawal, I was rapidly cycled through venlafaxine for three months, escitalopram for two weeks, citalopram for one week, propranolol for three weeks and pregabalin for five days, along with 5-10mg diazepam to “manage” the avalanche of adverse reactions. Diagnosed with adverse reactions such as serotonin syndrome. No mention of withdrawal. Each drug made things worse.
GP 2: By this point I had moved back in with my parents because I could no longer look after myself. Highly suicidal, horrific akathisia and unable to sleep for days. Prescribed mirtazapine, which made the akathisia significantly worse. Took for three weeks.
Mental Health Nurse: Switched to duloxetine. Denied it could be withdrawal. Took duloxetine for one week and the akathisia reached a new level of hell.
NHS Psychiatrist 1: Referred to secondary care. Prescribed vortioxetine. I refused because I was terrified the drugs were making me worse. Told this was relapse and an emerging mood disorder, possibly FND.
NHS Psychiatrist 2: Suspected Sertraline withdrawal but advised reinstating at 50mg and increasing weekly to 150mg, plus 5mg diazepam three times daily. I declined after finding information on low dose reinstatement (0.5–1mg) in support groups. Also didn’t want to become dependent on a benzo and was worried about the rapid benzo taper he had proposed with my already fragile CNS.
Private Psychiatrist (Priory): Paid £450. Told it was obvious I couldn’t tolerate SSRIs and had likely developed bipolar or another mood disorder. Prescribed flupentixol. I had never been psychotic and refused. £450 I’ll
never get back.
NHS Psychiatrist 4: Attended A&E with unbearable akathisia and high suicidality. Prescribed PRN quetiapine (25mg up to 4x/day) plus 200mg at night. Developed extrapyramidal symptoms (urinary retention, hand tremors) and was told it was “just anxiety” and “couldn’t be the drugs.” Stopped the 200mg after two nights and have remained on 25mg since.
Psychiatrist 4 (again): Insisted I wasn’t in withdrawal, told me to stop visiting online forums and dismissed scientific papers I presented as “nonsense.” Prescribed lamotrogine and in desperation for my life I tried for two weeks. Akathisia flared to life threatening levels.
Psychiatrist 4 (again): Stopped lamotrigine and prescribed Abilify. By now I refused, as I recognised this as drug induced and had never been psychotic.
Psychiatrist 5: Called me a “difficult patient” and encouraged voluntary hospital admission to increase quetiapine and possibly consider ECT. It was clear neither they nor the system understood withdrawal. I made the decision to leave psychiatric care entirely in order to save my own life.
GP 3: A new GP open to learning. I gave her The Maudsley Deprescribing Guidelines. She was empathetic, supported low dose reinstatement (though still suspected FND) and helped advocate for me. Unfortunately the CNS injury was too severe for reinstatement to work and so I remain on 3mg of sertraline and 25mg of quetiapine to this day. Referred to neurology.
Neurologist: Agreed it was AD withdrawal but still recommended the FND pathway. I challenged this, saying I would be taking a place from someone with genuine FND. They admitted they see many psychiatric drug reactions in neurology but “can’t rock the boat.”
GP 3: Referred me to an NHS deprescribing clinic and provided what support she could.
Psychiatrist 6 (Deprescribing Clinic): Finally validated everything I’d been through and quite possibly saved my life. The care I’ve received there has been exceptional.
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🧵Gulf War Syndrome & Simon Wessely
"For 30 years they have been disowned, ignored and lied to by consecutive governments, with no positive answers to their questions about exposure to toxic substances and gases & the affect it had on them"
bbc.com/news/health-61398886
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“Physically, Long COVID has absolutely just ruined my life.”
“Doctors just don’t know what to do with you.”
“There’s no help coming your way.”
People living with #LongCovid describe how the illness has changed their lives. Highlights from a PBS NewsHour report aired in 2023.
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How long will people with Long COVID (& ME/CFS!!) have to wait until this public health emergency is taken seriously?
#LongCovidAwareness2025 #5YearsLongCOVID
#HalfADecadeOfNeglect
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Interesting interview. Vanheule suggests psychosis is a human experience (not a disease), a 'non-standard' reaction to a difficult or perceived-to-be threatening situation. madinamerica.com/2025/06/why…
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Replying to @KatieRColl @NHSuk
NHS trusts largely look after themselves and have total disregsrd for patients: independent.co.uk/news/uk/nh…
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When you take an SSRI you are not correcting a chemical imbalance... you are inducing one. Be aware of those consequences. They are not benign.
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I never met someone who is severely depressed for no reason. The interventions should be entirely based on the root causes that created that state in the first place. Its never “low serotonin”.
So absurd and harmful. The verdict has been in for years.
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We are now at nearly 100 million prescriptions of antidepressants dispensed in England each year (nearly double 10 years ago)- with people in the poorest communities being medicated most, and rising prescribing among women and children.
telegraph.co.uk/news/2026/08…






















