@RotAntal

Light on DARC and Other Atypical Chemokine Receptors!

 Europe
Joined August 2021
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Different COVID-19 vaccine formulations have distinct effects on the stromal cell landscape and function of draining lymph nodes @SciImmunology @SalmiLab science.org/doi/10.1126/scii…
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In our recent Sci. Signal. paper by Gutjahr et al. @GutjahrJulia 10.1126/scisignal.adt2678 we did not discuss in detail this point: "Using CXCL12 should improve the efficiency of in vitro blood production" Fortschritt in der künstlichen Blutproduktion idw-online.de/-DQuTAA
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This paper: science.org/doi/10.1126/scis…

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and...

CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

science.org
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A team finds that the #chemokine CXCL12 can support the production of #RedBloodCells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. @stevenduke @GutjahrJulia @QMULWHRI scim.ag/446wONU
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Un joli erythroblaste. Un érythroblaste est une cellule jeune de la lignée des globules rouges, présente dans la moelle osseuse. Elle contient encore un noyau, ce qui la distingue des globules rouges matures (érythrocytes), qui en sont dépourvus.
ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE@DucheneJohan27 Jun 2025
#FluorescenceFriday & Erythroblast Erythroblast stimulated with CXCL12, stained for CXCR4 (green) and nuclei (blue). Captured via Correlative Light & Electron Microscopy by @JemimaBurden Learn more: scim.ag/4kTxFZz @GutjahrJulia @RotAntal @ScienceMagazine @scisignal
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#FluorescenceFriday & Erythroblast Erythroblast stimulated with CXCL12, stained for CXCR4 (green) and nuclei (blue). Captured via Correlative Light & Electron Microscopy by @JemimaBurden Learn more: scim.ag/4kTxFZz @GutjahrJulia @RotAntal @ScienceMagazine @scisignal
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In a new study, researchers find that the chemokine CXCL12 can support the production of red blood cells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. Learn more in @SciSignal: scim.ag/4kTxFZz
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In a new study, researchers find that the chemokine CXCL12 can support the production of red blood cells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. Learn more in @SciSignal: scim.ag/4kTxFZz
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A team finds that the #chemokine CXCL12 can support the production of #RedBloodCells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. @stevenduke @GutjahrJulia @QMULWHRI scim.ag/446wONU
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A preclinical study uncovers a metabolic pathway that offers a target in neuropathic pain, scientists discover how chemokines can support red blood cell production in mice, and more this week in #ScienceSignaling. scim.ag/3HEv8no
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Not all chemokine signaling is about cell migration! In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation. 🔗 science.org/doi/10.1126/scis… #chemokine #CXCR4

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and...

CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

science.org
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science.org/doi/10.1126/scis… We describe the hitherto overlooked expression of CXCR4 in erythroblasts, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, CXCR4 localises to the nucleus and mediates alternative responses in erythroblast maturation and enucleation
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Although chemokines are known for their role in cell migration, new work in mice shows that CXCL12 also promotes the differentiation of #erythroblasts by promoting CXCR4 signaling and activity in the nucleus. @stevenduke @GutjahrJulia @QMULWHRI scim.ag/446wONU
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CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells @scisignal @GutjahrJulia @RotAntal science.org/doi/10.1126/scis…
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Open access link can be found here: bitg.ch/eBITg_site/de_publi_…
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Proud to share that our recent publication in Science Signaling has been featured on the Science website today! 🧬🔬 It’s a great feeling to see our work reach a broader audience. Many thanks to all collaborators Check out the feature here: science.org/ #Science
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Dime un jugador del Real Madrid así
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Poorly validated antibodies fuel the reproducibility crisis. @YCharOS1 shares a protocol for antibody validation using KO cell lines tinyurl.com/NP-article tinyurl.com/NP-comment Glad that our study is cited as an example for improving data quality tinyurl.com/CSC-Letter
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🚀 New Postdoc Position 🚀 We offer a 3-year postdoc position to investigate how vascular #aging impacts #immunecell function. 🔬 We’d be grateful if you could help spread the word! 🙏 @QMUL @QMULWHRI 👉qmul-jobs.tal.net/vx/mobile-… #Postdoc #AcademicTwitter #ResearchOpportunity
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Only 8K? possible to screen all of these quickly, in ....decades. Would there be grant money to finance such massive katharsis?
ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE@DucheneJohan26 Sep 2024
Replying to @RotAntal
Well apparently 8000 genetically modified mice are derived from 129 ESCs... cell.com/immunity/fulltext/S…

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice

The importance of genetic background in genetically modified congenic mice is well known. Vanden Berghe and Vandenabeele and colleagues predict through comparative genomics (webtool) that nearly all...

cell.com
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