@RossWilsonLab
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CRISPR whisperer in perpetual training. We're working to enable safe & accessible delivery of genome editing therapeutics. @igisci @UCBerkeley https://nitter.cf/t.co/89o53zRYUa
Joined December 2019
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I’m excited to share our report - out now in @natBME - of a new approach to CRISPR delivery that is poised to transform the way engineered T cell therapies are manufactured. Visit tinyurl.com/CRISPR-PERC for “how to” details. It’s threadin’ time! (1/11) nature.com/articles/s41551-0…
Ross Wilson retweeted
🧬 Can CRISPR dial down α-synuclein instead of knocking it out?
MTI winners Ross Wilson & Hanqin Li aim to halt Lewy bodies with precision base editing - $90 K + full platform support.
#CRISPR #Parkinsons #MTIAwards
🔗 Read more at moleculartherapeutics.org/20…
Ross Wilson retweeted
Inaugural post! (after a long hiatus)
Last May I quit my job to build @dittobio with @Mezarque and @emilycpierce ! We turn parasite molecules into drugs for autoimmune disease, and are part of the @ycombinator W26 batch.
Thanks for betting on us @agupta
Big news! Our team developed Neuro-PERC, a non-viral CRISPR delivery platform for genome editing of the brain. In our new preprint - bit.ly/NeuroPERC_pre - we report efficient editing in multiple models & species, including field-first results in large animals (pigs) 🧵👇
Together, these findings establish Neuro-PERC as a versatile, scalable, well-tolerated platform… as well as a promising candidate for clinical translation in neurotherapeutics. 🐭🐷🧠🧬✂️
Huge credit to @BrigetteManohar for leading this collaborative effort based at IGI & @berkeleyMCB, which would have been impossible without major contributions from OSU's @TNeuroSci_Lab @RussellLonser and support from NIH's SCGE consortium @somaticediting
Cas9 gets an upgrade! Check out our new paper in The CRISPR Journal: bit.ly/hiNLS-Cas9 Eric Noel (who is on the job market!) created Cas9 constructs w/ nuclear localization signals (NLS) in the backbone, boosting genome editing activity in T cells. #CRISPR
What did we see?
• hiNLS constructs supported high yields
• hiNLS can improve genome editing efficiency
• this was true via 2 delivery methods:
electroporation & PERC (peptide-mediated)
• more NLS is better, but only up to a point
Credit to T cell editor @srishtiupasana!
Thanks to @GENbio for putting together a nice write-up on this work, which is available here: bit.ly/GEN-hiNLS
We put our two favorite hiNLS constructs on @Addgene for anyone interested in giving them a try:
addgene.org/search/catalog/p…
Ross Wilson retweeted
New Strategy Enhances CRISPR Editing Efficiency for Therapeutic Use
In a new April 2025 @CRISPRjournal published study, IGI @UCBerkeley researchers leverage new constructs for NLS sequences to improve editing efficiency in human immune cells
#crispr
hubs.li/Q03hZVqv0
