PI at Max Planck Institute for Medical Research | Chemically Induced Proximity | Gain-of-Function | Stanford Postdoc | PhD 2021 ETH Zürich
Heidelberg, Germany
Joined October 2019
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Roman Sarott retweeted
Nathanael Gray @StanfordUChem about bifunctional proximity-inducing molecules which allow to rewire transcription #AACR26. TCIPs hijacking BCL6, BRD4, CDK9, p300 and p53 Y220C as “synthetic hybride TFs” leading to transcriptional hyperactivation & gain-of-function pharmacology.
Roman Sarott retweeted
Cool paper from Crabtree and Gray labs: biorxiv.org/content/10.1101/…
Roman Sarott retweeted
🚀 Great news!
With support of the Dieter Schwarz Foundation, the #MaxPlanckSchools will keep growing. The funding boosts top-tier research & training—#ShapingTheFuture of science! Read more at bit.ly/3DQR9NZ
@maxplanckpress
@HRK_aktuell
ALT An open palm with a launching rocket, surrounded by symbols such as light bulbs and gears
Roman Sarott retweeted
Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber!
If you are a trainee interested in ambitious projects at the intersection of chemical biology and cancer biology, please reach out!
gibsonlab.org
Roman Sarott retweeted
Explore the outstanding contributions by @francesarnold, @AlisonNarayanUM, @FlitschSabine, @HartwigGroup, @CarreiraGroup, @Shenvi_Lab, @hanzyduzit, @AdibekianG, @DrNitinAPatil, @RomanSarott, @ziyangnickqin, @LauraMBohnPhD1, @SHIONOGI_JP @ACSCentSci pubs.acs.org/doi/10.1021/acs…
Check out this new Collection from @ACSCentSci, showcasing the latest advances in organic synthesis and catalysis, highlighting innovative strategies for the construction of pharmaceutically relevant compounds, natural products, and drugs.
Learn more: go.acs.org/bZm
Can‘t wait to get started!🥳 Thank you @mpi_mr_hd for making my transition so smooth:)
🎊🎉Exciting news: @RomanSarott will join us in January as a new Research Group Leader and will establish the group “Chemically Induced Proximity”. We look forward to seeing you again in January, dear Roman! 🤩👏mr.mpg.de/14599628/chemicall…
Roman Sarott retweeted
🎊🎉Exciting news: @RomanSarott will join us in January as a new Research Group Leader and will establish the group “Chemically Induced Proximity”. We look forward to seeing you again in January, dear Roman! 🤩👏mr.mpg.de/14599628/chemicall…
Roman Sarott retweeted
Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from Multicomponent Combinatorial Library JACS @fischerlab1 @DanaFarber @harvardmed @Stanford @StanfordMed @StanfordCancer @RomanSarott #CRBN #Wee1 #MolecularGlue #Degraders #Multicomponent #Library pubs.acs.org/doi/10.1021/jac…
Multicomponent reactions for molecular glue discovery,
Congrats @HRazumkov and @ZzzxJiang !
Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library | Journal of the American Chemical Society pubs-acs-org.stanford.idm.oc…
here with link that works for non-Stanforders...
pubs.acs.org/doi/10.1021/jac…
Roman Sarott retweeted
Postdoc opportunity to work with Weizmann and Max Plank, superb funding. Enjoy the best of both worlds.
weizmann.ac.il/sites/mpg-wis…
Bivalent molecules unmute silenced genes nature.com/articles/d41573-0…
Roman Sarott retweeted
We can now activate p53 Y220C by recruiting BRD4 to it with small molecule TRAP-1. This was a great collaboration with Gray lab and Attardi Lab @Stanford lead from @UniBonn @UniklinikBonn by @dpienkowska9 & @JanGerhartz.
biorxiv.org/content/10.1101/…
Roman Sarott retweeted
New work from Nat Gray lab...
Discovery of a small molecule chemical inducer of proximity that activates mutant p53 by linking to BRD4. Highlights how chemically induced proximity can be used to restore the functions of tumor suppressor proteins.
biorxiv.org/content/10.1101/…
Fantastic feature story on our work on hijacking kinases to kill cancer cells - thank you @JuliaBauman2 for the highlight!
Really nice new cancer drug modality: Chemical induction of proximity to hijack the activity of a cancer driver!
From @RomanSarott @saigourisankar @baselakarim in the Gray & Crabtree labs @Stanford
If precision gene modulation with small molecules sounds fun - my starting lab @mpi_mr_hd is looking for postdoc candidates in molecular biology!
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Can we turn the activity of oncogenic kinases against cancer itself?
In my postdoc work @Stanford, new in @sciencemagazine, we show exactly that.
science.org/doi/10.1126/scie…
#ScienceResearch #InducedProximity @Stanford_ChEMH @StanfordCancer @snsf_ch @StanfordMed
Leveraging chemically induced proximity, we convert kinase inhibitors into locus-specific activators of gene expression.
In place of a tweetorial here a video that @saigourisankar and I got to do with @FNucleosome.
youtu.be/-eNl-ByXB-E?si=VhY4…
I am deeply grateful for the fantastic group of scientists that I had the privilege of working with: Nathanael Gray, Gerald Crabtree, @GreenLymphoLab, @baselakarim, @NettlesSabin, @HinshawStephen, and all those not on twitter.