@RobBeagrie

@WellcomeTrust Sir Henry Dale Fellow based at @HumanGeneticsOx, interested in chromatin disruption in human disease. He/him. Mastodon: [email protected]

 UK
beagrielab.com
Joined June 2013
  • Tweets675
  • Following737
  • Followers600
8Media
🚨 Job alert Hiring a postdoc (comp or wet lab) to work on chromatin & genetics 🧬 Come work with us @HumanGeneticsOx in the beautiful @UniofOxford 🗓️ Closing September 13th Details at beagrielab.com/join Pls share and RT! #PostdocJobs #GeneticsJobs #genomics #cohesin
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Very happy to have been able to help out with this one - some very cool work! #genomics
Jim R. Hughes@jrmmhughes21 Aug 2024
Great collaboration between the @FoldingGenome and Watkins labs, reporting the first Gain of Function de novo enhancer causing Mendelian disease (ST Depression Syndrome), defining a multidisciplinary path with ML to solving non-coding clinical genetics. medrxiv.org/content/10.1101/…

An autosomal dominant cardiac arrhythmia syndrome, ST Depression Syndrome, is caused by the de novo...

A substantial proportion of mutations underlying rare Mendelian diseases remain unknown, potentially because they lie in the non-coding genome. Here, we report the mapping of the causal mutation of...

medrxiv.org
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Rob Beagrie retweeted
Wilkie Lab@Wilkie_Lab28 Feb 2024
Calling all rare disease researchers and clinicians who have a variant of uncertain significance... 🧬 The @MRCMouseNetwork & @NMGN_CongAnom (co-led by our PI @srftwigg) are currently looking for VUSs to model in mice! 🐭 (1/2)
A flyer advertising details of the call for variants of uncertain significance.

ALT A flyer advertising details of the call for variants of uncertain significance.

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And it’s #PhDone! Rachel Kimber, first PhD student in my lab @BabrahamInst, has brilliantly defended her thesis today. Thanks to @carovinuesa and @viropractor for examining Rachael’s thesis. Well done, Dr. Kimber 🥳 🎉🥂
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Fantastic day talking science @BigDataIns. Thanks for the invitation to share our research @RobBeagrie - it was great to see some familiar faces (the lovely Yang Shi!), put some faces to names/emails, and meet some new!
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If you are willing to learn low input techniques to explore the chromatin of your favourite organism, don't hesitate to apply to this hands-on course! We'll be teaching you Low-C, ATAC-seq, CUT&RUN, and its bioinformatic pipelines.
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Applications are now OPEN for an internship in my group at Oxford University. Open to UK undergraduates from under-represented and disadvantaged backgrounds – apply by Wednesday 21 February 2024 to join us this summer: ox.ac.uk/admissions/graduate…

What is UNIQplus?

Read about the opportunities and benefits of applying to UNIQplus.

ox.ac.uk
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Very excited to share that our work reconstructing chromothripsis has now been published in @CellGenomics! We reconstructed chromosomes with up to 800 rearrangements on a single allele and queried epigenetic and transcriptomic consequences. Thread below! cell.com/cell-genomics/fullt…

Haplotype-specific assembly of shattered chromosomes in esophageal adenocarcinomas

Ijaz et al. reconstructed chromothriptic and wild-type chromosomes in patient-derived esophageal adenocarcinoma organoids using a haplotype-aware method. Upon these assemblies, they layered epigene...

cell.com
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Rob Beagrie retweeted
ISCB RegSys@ISCB_RegSys5 Jan 2024
Submissions for technology track presentations are also open - go to iscb.org/ismb2024/submission… and apply by May 10th to showcase your bioinformatics/molecular biology software or hardware to the community #Bioinformatics #ComputationalBiology #ISMB2024
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Rob Beagrie retweeted
ISCB RegSys@ISCB_RegSys5 Jan 2024
You can now submit your new, unpublished work for publication as a proceedings paper at ISMB 2024! Full details are available at iscb.org/ismb2024/submission… - the deadline is January 25th #Bioinformatics #ComputationalBiology #ISMB2024
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Applications are now open for a fully funded @SoCoBioDtp PhD project with myself (@sotonbiosci ) and Jerome Swinny (@portsmouthuni) … please get in touch to discuss the project! Deadline Jan 8th.
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Is anyone here using the UKBiobank 200k genomes dataset? We are having some weird issues and are trying to troubleshoot if data vs code 😬 Anyone else seeing anything odd? Either way, please share! 🧬
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How cis-regulatory elements interact to regulate gene expression-role of CTCF and cohesin- check out our pre-prints @MRC_WIMM @jrmmhughes @FoldingGenome @RobBeagrie @JefBoeke @MolecularCell @NAR_Open @CTCF_Papers @generegulation biorxiv.org/content/10.1101/… biorxiv.org/content/10.1101/…

Loop extrusion by cohesin plays a key role in enhancer-activated gene expression during different...

Enhancers and their target promoters often come into close physical proximity when activated. This proximity may be explained by a variety of mechanisms; most recently via cohesin-mediated chromatin...

biorxiv.org
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Looking to do a PhD in 2024? Interested in gene regulation, chromatin and disease? Applications are now open so come join beagrielab.com at the @HumanGeneticsOx ! Further details below but if you're interested DM me to talk about possible projects. Deadline Dec 1st 1/3
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There are two different DPhil programs you can apply to: if you want first-year rotations and more of a focus on computational biology then you might be interested in our DPhil in Genomic Medicine and Statistics well.ox.ac.uk/study/gms 2/3
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If you know what you want to do and are ready to jump straight into a project, you might be interested in a DPhil in Clinical Medicine ox.ac.uk/admissions/graduate… - happy to talk through the differences with any interested candidates 3/3
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Rob Beagrie retweeted
Anton Henssen@anton_gh19 Jun 2023
Congrats @apombo1 @LabPombo !!
Nature Methods@naturemethods19 Jun 2023
Multiplex-genome architecture mapping (multiplex-GAM) facilitates rapid, unbiased and ligation-free determination of chromatin interactions, as compared to Hi-C. @apombo1 @RobBeagrie @anto_scial @LonnieRWelch @LabPombo @helmholtz_de nature.com/articles/s41592-0…
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Multiplex GAM is out! Congrats @LabPombo @apombo1 !! Coming to a brain near you!! nature.com/articles/s41592-0…

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C

Nature Methods - Multiplex-genome architecture mapping (multiplex-GAM) enables rapid, unbiased, ligation-free mapping of genome-wide chromatin interactions.

nature.com
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Multiplex-genome architecture mapping (multiplex-GAM) facilitates rapid, unbiased and ligation-free determination of chromatin interactions, as compared to Hi-C. @apombo1 @RobBeagrie @anto_scial @LonnieRWelch @LabPombo @helmholtz_de nature.com/articles/s41592-0…
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The paper about CIARA - our method to find rare cells in scRNAseq data - is now published in Development! One of the major additions to the preprint is the analysis of scATAC-seq datasets, showing how CIARA can find rare cells in other types of single-cell omic datasets too.
Development@Dev_journal12 Jun 2023
CIARA: a cluster-independent algorithm for identifying markers of rare cell types from single-cell sequencing data Read this Techniques and Resources Article by Gabriele Lubatti, Marco Stock, Ane Iturbide, @anto_scial & colleagues @HelmholtzMunich: journals.biologists.com/dev/…
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