Tumor Immunologist and Engineer @Stanford.
Stanford, CA
Joined November 2018
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Tumors spread to lymph nodes before they metastasize to distant tissues, but for over a century scientists have debated whether this matters. It does. Check out our paper online now @CellCellPress @CellPressNews
cell.com/cell/fulltext/S0092…
1/15
Nathan Reticker-Flynn retweeted
Finishing your PhD or looking for a post-bac research position? We’re recruiting multiple postdocs and research technicians to study somatic evolution!
Come do interdisciplinary science in a friendly, collaborative environment at @harvardmed Genetics.
naxerova.hms.harvard.edu/con…
If you're interested in hearing about lymph node metastasis, tumor evolution, T cells, and immunotherapy, check out this @theNCI forum tomorrow, featuring Mary Jo Turk, @naxerova, and Alexander Huang. events.cancer.gov/dcb/tdln #TDLNForums
When tumors colonize lymph nodes, they induce a LOT of changes to the immune and stromal populations in the involved LN and beyond, throughout the induction of Metastatic Tolerance. Check out this great study and rich resource describing these changes. Congrats @Max_Haist !
Online Now: Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance dlvr.it/TQflcw
Nathan Reticker-Flynn retweeted
Happy to share our latest @sigtrans_sttt commentary on two beautiful @Nature papers on #ferroptosis and #cancer. Kudos to these 2 teams for their beautiful work! @j_ubellacker @luciaborriell @FoxChaseCancer nature.com/articles/s41392-0…
Thanks to @NatRevImmunol and the @preprintclub for highlighting our recent study on divergent evolution and type I interferon
Type I interferon at the crossroads of metastatic dissemination bit.ly/44XMMuS
Nathan Reticker-Flynn retweeted
Evolution Under Therapy: Resistance Mechanisms—
Andrew J. Aguirre, Nathan E. Reticker-Flynn, Susan M. Rosenberg, and Kathleen Burkhardt addressed this topic in a plenary session at the AACR Special Conference on Cancer Evolution.
#AACRevol25 @RetickerFlynn @SusanRosenberg8
Nathan Reticker-Flynn retweeted
What if nature already has the optimal cytokine solution for T cell therapy, but we just haven’t found it yet? Check out our paper out today in Immunity on IL-9 as a naturally orthogonal cytokine ideally tuned for T cell therapy authors.elsevier.com/sd/arti…
1/9
Nathan Reticker-Flynn retweeted
Nature research paper: Lymph node environment drives FSP1 targetability in metastasizing melanoma
go.nature.com/4oiPnY2
Nathan Reticker-Flynn retweeted
Thrilled to see Mario's work on FSP1 out, providing evidence in melanoma alongside lung cancer that there may be alternatives for targeting ferroptosis! Glad we could help with this work including providing our LN metastasis model for in vivo validation
Nature research paper: Lymph node environment drives FSP1 targetability in metastasizing melanoma
go.nature.com/4oiPnY2
Nathan Reticker-Flynn retweeted
Therapeutic benefit of intratumoral inhibition of FSP1 & ferroptosis in pre-clinical lung cancer and versus melanoma growth in lymph nodes @Nature @ThalesPapaG @nyugrossman @HarvardEpi
nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
Nathan Reticker-Flynn retweeted
Two new Nature papers show that inhibiting FSP1 is sufficient to restrict tumor growth in vivo, a major step forward for ferroptosis-targeted cancer therapy.
Huge congrats to all authors!
nature.com/articles/s41586-0…
nature.com/articles/s41586-0…
#Ferroptosis #FSP1 #CancerResearch
Nathan Reticker-Flynn retweeted
Evolution Under Therapy: Resistance Mechanisms—
Andrew J. Aguirre, Nathan E. @RetickerFlynn, @SusanRosenberg8, and Kathleen Burkhardt will address this topic in a plenary at the AACR Conference on Cancer Evolution (Dec 4-6; Albuquerque).
brnw.ch/21wWYfD
#AACRevol25
Tumors often metastasize to lymph nodes before distant sites, yet evidence suggests that distant mets can originate from unique clones. Is this divergent seeding random? No. Check out our newest @biorxivpreprint to learn how the mechanisms diverge and how to harness them for IO.
I’m excited to share the first major story from my PhD today on the complex role of type 1 interferon in metastasis and immunotherapy!
This work was made possible with the support of @RetickerFlynn, Marcos Labrado, and the incredible protein engineer @grayerodriguez
See the tweetorial from @CortBreuer ☝️and the preprint 👇
biorxiv.org/content/10.1101/…
Nathan Reticker-Flynn retweeted
Pleasure to share a tremendous body of work from @YangZhao102, who led the next chapter of the powerful orthogonal IL-2 technology from the Garcia Lab (where the innovative spirit is unmatched).
Grateful for this ongoing collaboration, stay tuned for more. rdcu.be/eACgC
Nathan Reticker-Flynn retweeted
Excited to see our protocol out today on spontaneous and experimental models of LN metastasis in @NatureProtocols! Though a straightforward system conceptually, getting these models working reliably took more time than originally expected so I hope this is a resource to everyone.
Interested in studying lymph node metastasis? Check out our protocol by @CortBreuer out today in @NatureProtocols
If you're interested in trying out these protocols in your own lab, we are making the cell lines available through @CancerToolsOrg
cancertools.org/cell-lines/n…
And if you're interested in investigating what is happening in the lymph fluid itself, check out this great protocol by the Ubellacker Lab
nature.com/articles/s41596-0…