@Renhao4

PhD student @scrippsresearch | Previously @HarvardDBMI + @mghcvrc + @MonteRosaTx | He/Him/His

 San Diego, CA
Joined January 2018
  • Tweets48
  • Following437
  • Followers90
5Media
I'm glad to be part of this and excited to see how the story unfolds from start to finish! Congrats everyone!
Christiane Wrann, PhD, DVM
@WrannLab12 Jun 2025
Our latest study is out in Nature Neuroscience! 🧠💪We dissected protective exercise responses in the dentate gyrus in Alzheimer's disease at single-cell resolution. Proud of the team's hard work and collaboration! 🔗 doi.org/10.1038/s41593-025-0… @mghcvrc @NR_Tucker @MGBResearchNews @mghNeuroSci @UpstateResearch @NatureNeuro #Neuroscience #BrainHealth #ExerciseScience #Alzheimers #AcademicTwitter

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with...

Nature Neuroscience - Dissecting the adaptive exercise response of the neurogenic stem-cell niche in the dentate gyrus by single-nucleus RNA sequencing reveals the molecular mediators that underlie...

nature.com
2
197
Incredible effort from @bradentierney and I am honored to continue to work with him. Imagine the medicines we might be able to mine or toxicants removed from harms way? nytimes.com/2025/10/06/clima… @harvardmed @twofrontiers @nytimes 💪

The Very Hungry Microbes That Could, Just Maybe, Cool the Planet (Published 2025)

They feast on bubbles of methane seeping out of the ocean floor. Could their appetites be harnessed to slow climate change?

nytimes.com
1
4
8
1,038
Over the last 6 years we @MonteRosaTx have pushed the limits on molecular glue degrader design. The term MGD didn’t even exist 6 years ago! Very proud of the team and exited about what the technology holds! Go QuEEN! Aye-Oh!
Science Magazine
@ScienceMagazine3 Jul 2025
New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation. Learn more in this week's issue: scim.ag/4lauo8j
This illustration shows the interface of the kinase NEK7 (light blue) and the E3 ubiquitin ligase substrate receptor cereblon (teal). The interaction is facilitated by the small molecule MRT-3486 (orange).

ALT This illustration shows the interface of the kinase NEK7 (light blue) and the E3 ubiquitin ligase substrate receptor cereblon (teal). The interaction is facilitated by the small molecule MRT-3486 (orange).

1
5
22
2,491
New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation. Learn more in this week's issue: scim.ag/4lauo8j
This illustration shows the interface of the kinase NEK7 (light blue) and the E3 ubiquitin ligase substrate receptor cereblon (teal). The interaction is facilitated by the small molecule MRT-3486 (orange).

ALT This illustration shows the interface of the kinase NEK7 (light blue) and the E3 ubiquitin ligase substrate receptor cereblon (teal). The interaction is facilitated by the small molecule MRT-3486 (orange).

20
92
11
496
330,447
Heartbroken to share my mentor & friend Dr. Atul J. Butte @atulbutte has passed. He saw potential in me and turned it into opportunity-- for me, and so many others. We bonded over Star Trek and he was our Captain. Picard’s parting toast in his honor, final episode: “....five-card stud, nothing wild… and the sky’s the limit.” youtu.be/mt3MVP3FizQ?si=JRuH…
9
25
1
197
17,308
Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing @WrannLab, @MGBResearchNews, @NR_Tucker, @UpstateResearch nature.com/articles/s41593-0…
13
3
44
7,756
While exercise has long been known to benefit the brain, the specific cells responsible remained unclear—until now. Learn about new research from @MGBResearchNews and @UpstateNews, and its connection to Alzheimer's disease. spklr.io/6010B6Wan #AlzheimersAndBrainAwarenessMonth
5
10
1,020
Interested in diffusion models, behavior forecasting, internal states, neuromechanical modeling, reservoir computing, joint neural/behavioral datasets? Missing the sunshine? We have multiple fully funded postdoc positions, come join us!
The Kennedy lab is recruiting for multiple funded postdoctoral positions in theoretical and computational neuroscience, following our recent lab move to Scripps Research in sunny San Diego, California. Ongoing projects in the lab span topics in: - reservoir computing with heterogeneous cell types - reinforcement learning/control theory analysis of complex behavior - neuromechanical whole-organism modeling - imitation learning/forecasting of mouse social interactions - joint analysis/modeling of effects of internal states on neural + vocalization + behavior data Projects are flexible and can be tailored to applicants’ research and training goals, and there are abundant opportunities for new collaboration with local experimental groups. We offer competitive postdoctoral stipends that reflect coastal cost-of-living expectations and include a relocation bonus, with research professorship positions available for qualified applicants. Info at kennedylab.org. Contact akennedy@scripps.edu

ALT The Kennedy lab is recruiting for multiple funded postdoctoral positions in theoretical and computational neuroscience, following our recent lab move to Scripps Research in sunny San Diego, California. Ongoing projects in the lab span topics in: - reservoir computing with heterogeneous cell types - reinforcement learning/control theory analysis of complex behavior - neuromechanical whole-organism modeling - imitation learning/forecasting of mouse social interactions - joint analysis/modeling of effects of internal states on neural + vocalization + behavior data Projects are flexible and can be tailored to applicants’ research and training goals, and there are abundant opportunities for new collaboration with local experimental groups. We offer competitive postdoctoral stipends that reflect coastal cost-of-living expectations and include a relocation bonus, with research professorship positions available for qualified applicants. Info at kennedylab.org. Contact [email protected]

3
26
1
82
15,040
Looking to hire scientists (at all levels) to develop new computational models and AI approaches to map the exposome! Data across multiple scales are staged and ready to analyze! 🤓💻 check out: bit.ly/patelgrouphire and DM or email! @Hossein_Estiri @arjunmanrai @francescadomin8 @josep_mercader @GaryWMiller3
22
1
43
5,837
Our second years @AllisonBarkdull, @YutingZhan8328, and @Renhao4 received lab coats this weekend! #computationalscientists #whataretheygonnadowithlabcoats
3
26
1,426
Haven't we learned anything about stopping pandemics? When it comes to government policy and COVID-19, the answer is: "no, we don't have the data." I write an op-ed with Eran Bendavid in @statnews: statnews.com/?p=1165584 about our research paper in @ScienceAdvances: science.org/doi/10.1126/scia…
6
20
12
70
39,683
Evaluation of the heterogeneity of odds ratios for 12 risk factors reported from the Lancet 2020 report and two non-modifiable factors on dementia. Read the full study here: bmcmedicine.biomedcentral.co… @Renhao4 @DenaZera @MariaGlymour @randalljellis @Hossein_Estiri @chiragjp.
4
5
871
1/2 In 2020, a Lancet report highlighted 12 modifiable key risk factors for #dementia (e.g., traumatic brain injury [TBI], air pollution, loneliness, education, #diabetes, and genetics); some of these factors are being pursued as points of intervention for #dementia. @HarvardMS alum @Renhao4 (now PhD at @Scripps) used Specification Curve Analysis (SCA) in #UKBiobank to examine how risk changes across dementia classifications and interrelationships between risk factors. Consistent factors included #TBI, while factors like #diabetes were less consistent. SCA helps map data-related or analytic heterogeneity to improve risk estimates, important for translation! thx to coauthors @DenaZera @MariaGlymour @Hossein_Estiri @randalljellis Paper: bmcmedicine.biomedcentral.co…
1
5
12
2,143
I am thrilled to announce that my master project @HarvardDBMI is out in @BMCMedicine today! We studied the robustness of different dementia risk factors across subtypes and scenarios using Specification Curve Analysis (SCA) in the UK Biobank. (1/8) doi.org/10.1186/s12916-024-0…

Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from...

BMC Medicine - In 2020, the Lancet Commission identified 12 risk factors as priorities for prevention of dementia, and other studies identified APOE e4/e4 genotype and family history of...

link.springer.com
2
5
1
15
1,963
more replies
(6/8) Unattributed participants (with a dementia diagnosis but not specified subtype) correlated more with frontotemporal dementia in midlife and with vascular dementia and Alzheimer's in late life based on risk factor profiles.
1
169
(7/8) We identified and quantified sources of analytic heterogeneity in dementia risk factors, potentially due to different etiologies or misclassifications. Multivariate regression is crucial for independent estimates. Unclear how intervening on factors might alter risk.
135
Replying to @Renhao4 @HarvardDBMI @BMCMedicine
(8/8) A heartfelt thank you to @chiragjp for guiding me and brainstorming project ideas. And thanks to all the collaborators for their constructive suggestions on this project. @DenaZera @MariaGlymour @randalljellis @Hossein_Estiri
1
4
847
Load more