Professor of Molecular Biology. RNA, chromatin and transcriptional regulation.
UCL, London
Joined May 2016
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Richard Jenner retweeted
🧬 How does HP1α repress, and what happens when transcription is induced? Our new paper in @MolecularCell: HP1α stays bound, its barrier is local, and mouse chromocenters switch nanodomain by nanodomain. Paper: doi.org/10.1016/j.molcel.202… Thread with figures: bsky.app/profile/karsten-rip…
ALT Model scheme. Top, a silenced wild-type chromocenter with H3K9me3 nucleosomes and bound HP1α; VP16 is blocked, p65 and VPR activate it while HP1α and H3K9me3 stay. Bottom, a Suv39h dn chromocenter without HP1α, which p65 and VPR activate with acetylation and VP16 activates without it.
Richard Jenner retweeted
Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉
How do cells coordinate RNA processing with nuclear organization and the cell cycle?
nature.com/articles/s41556-0…
1/10
Richard Jenner retweeted
One of the (well, >1) problems in the lncRNA field is that some of the lncRNAs are not real genes, i.e., do not represent a standalone locus that produces independent transcripts. Some cases are more 🤔 than others, e.g. lncDACH that Matt Bennet from @bakergroupcvs dove into 🧵
Richard Jenner retweeted
This study identifies CpG islands at 3′UTRs as highly conserved, frequently methylated, and linked to cancer-related gene regulation. @Kanhere_Lab hubs.la/Q04qPckF0
Richard Jenner retweeted
Online Now: α-Satellite RNA maintains centromeric cohesion through R-loops dlvr.it/TTt08l
Richard Jenner retweeted
Excited to share the first pre-print from our lab!!
Check it out here! biorxiv.org/content/10.64898…
We found that many RNA-binding proteins understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Richard Jenner retweeted
Independent Senior Research Fellow position available! Working between UCL and UCLH, you will apply machine learning to digital pathology data and electronic health records to drive new insights in cancer biology and improve patient care.
To apply: lnkd.in/e9SX6WAT
Does PRC2 interact with RNA or is it an artefact? See our preprint showing how stringent denaturing purifications with spike-in controls support direct interaction between PRC2 and RNA in cells. biorxiv.org/content/10.64898…
ALT UV-crosslinked human cells containing Halo-tagged EZH2 were mixed with crosslinked mouse cells in which the protein was untagged and human EZH2 purified with Halo resin. Enrichment of human RNA (left) or mouse RNA (right) versus input was plotted against RNA abundance in the paired input sample. Windows with significant enrichment (p <10−6; binomial test) are shown in red. Human RNAs show enrichment versus input whereas mouse RNAs do not.
Richard Jenner retweeted
Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. nature.com/articles/s41587-0…
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our @MicahGoldrich and Louis Delhaye from @pieter_mestdagh. TL;DR we show that many of lncRNA chromatin occupancy maps are flawed🧵biorxiv.org/content/10.1101/…
Richard Jenner retweeted
Computational analysis is playing an ever increasing role in the detection, management and understanding of cancer.
Equip yourself with the knowledge and skills to lead work in these areas with our new MSc in Computational Cancer, run with @UCLmedphys
ucl.ac.uk/prospective-studen…
Looking forward to hosting the next meeting of the London RNA Club on RNA Regulation in the Nucleus.
Wednesday 25th March at UCL.
Speakers including @BrockdorffLab, @Vichaico, @RobertVendramin and Folkert van Werven.
eventleaf.com/e/LondonRNAClu… to register.
Richard Jenner retweeted
Come join our team!! linkedin.com/posts/quezada-l…
Richard Jenner retweeted
We’re excited to kick off 2026 with a joint meeting with the London RNA Club, featuring Mary Ann Allen and @stojic_lovorka!
🗓 Wednesday, February 25, 2026
⏰ 10:00 AM MST
📍 Zoom: please RSVP here for link: docs.google.com/forms/d/e/1F…
Supported by @RNASociety
Richard Jenner retweeted
To RNA aficionados! We are organising the @GenSocUK meeting “RNA in Physiology and Disease" in Newcastle from 7- 9 Sept. Many opportunities for short talks and an excellent line-up of speakers. More info👇
genetics.org.uk/events/rna-i…
Please share🙏
Richard Jenner retweeted
H3K79me2/3 is sufficient to antagonise PRC1 nature.com/articles/s41556-0…
Richard Jenner retweeted
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our @MicahGoldrich and Louis Delhaye from @pieter_mestdagh. TL;DR we show that many of lncRNA chromatin occupancy maps are flawed🧵biorxiv.org/content/10.1101/…
@UCLHresearchand & @uclcancer are recruiting an independent Research Fellow and Clinical Training Fellow.
Research areas: Cancer Immunotherapy, Early Diagnosis, Tumour Heterogeneity and Targeted Therapy and Non-chemo Treatments
ucl.ac.uk/work-at-ucl/search…
ucl.ac.uk/work-at-ucl/search…
Interested in applying your molecular biology skills to improve tumour immunotherapy?
@CRUKCOLcentre PhD studentship available in my lab @uclcancer in collaboration with @diunguyen_vn_uk @Bartscancer
For more information and to apply: colcc.ac.uk/phd-studentships…
Richard Jenner retweeted
Are you looking for a Clinical Research Training Fellowship? Do you want join our team working in cancer immunology and immunotherapy? Check this great opportunity from @CRUKCOLcentre
colcc.ac.uk/clinical-researc…
and contact our team to discuss our proposed project
Pleased to share our preprint describing a central role for post-transcriptional processes in the response to cancer immunotherapy. Huge amount of work led by Maria Vila de Mucha and @julia_hlond in collaboration with @QuezadaLab and @MartT_babraham 1/8
biorxiv.org/content/10.1101/…
Constitutive expression of Zfp36l1 in T cells nullified anti-tumour responses while knocking out Zfp36l1 and its paralogue Zfp36 released the block to GzmB protein production and promoted tumour control. 7/8