Immune Regulation and Tumour Immunotherapy Group led by @squezadd, based at the Cancer Institute of University College of London, UCL.
London, England
Joined September 2018
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Congrats to Aurélien Marabelle’s team — intratumoural anti-CTLA-4 links Treg reduction with FcγR⁺ myeloid context, underscoring the FcγR landscape as a key determinant of CPI activity and translation. nature.com/articles/s41586-0…
Quezada Lab retweeted
Congratulations to @CharlesSwanton, Mariam Jamal-Hanjani and colleagues on their fascinating analysis of the evolution of lung cancer metastasis published in @Nature!
nature.com/articles/s41586-0…
Quezada Lab retweeted
Thrilled to see a new paper led by the outstanding @Brown_lab1, now out in Nature Biotechnology.
We provide mechanistic insights into how mRNA vaccines work. challenging key assumptions and offering new ways to control vaccine activity. (1/3)
Read here: nature.com/articles/s41587-0…
Quezada Lab retweeted
Congrats to PICI researcher Dr. Catherine Wu of @DanaFarber on being part of the @CancerGrand ILLUMINE team, awarded $25M to explore the cancer dark proteome, research that could uncover entirely new targets for cancer treatment. bit.ly/4d1AxSV
Quezada Lab retweeted
Excited to share our new work uncovering a previously unknown mechanism identifying ANKIB1 as the E3 ligase that writes a critical new letter of the ubiquitin code central for immune signalling: K11-linked ubiquitin nature.com/articles/s41556-0…
Come join our team!! linkedin.com/posts/quezada-l…
Quezada Lab retweeted
Huge thanks to the team at UCLH and the UCL Cancer Institute @ucl @uclh @uclcancer, particularly Elise Reese @ekvrees and Louise Ainley, and my mentors Benny Chain @BennyChain, Sergio Quezada @QuezadaLab and Kwee Yong.
Quezada Lab retweeted
Immunology takes center stage again at the #NobelPrize! Congratulations to Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi for uncovering how regulatory T cells maintain immune tolerance—a discovery that transformed our understanding of autoimmunity and cancer immunotherapy
Are you looking for a Clinical Research Training Fellowship? Do you want join our team working in cancer immunology and immunotherapy? Check this great opportunity from @CRUKCOLcentre
colcc.ac.uk/clinical-researc…
and contact our team to discuss our proposed project
Quezada Lab retweeted
Pleased to share our preprint describing a central role for post-transcriptional processes in the response to cancer immunotherapy. Huge amount of work led by Maria Vila de Mucha and @julia_hlond in collaboration with @QuezadaLab and @MartT_babraham 1/8
biorxiv.org/content/10.1101/…
Quezada Lab retweeted
🧬 Join us Friday 19th Sept for CART Autoimmunity Symposium in Central London 🧬 Guest speakers from Erlangen & Hamburg on latest developments in Lupus, Multiple Sclerosis, & MG. Register in link below & see you there! @uclh @uclcancer hartleytaylor.co.uk/carm-hom…
Quezada Lab retweeted
Depletion of Tregs with a non-IL-2-blocking anti-CD25 enhanced antitumor responses in brain tumors and synergized with anti-PD-1 or a tumor antigen-targeted antibody bit.ly/44nab9T @uclcancer @QuezadaLab #Immunotherapy
Quezada Lab retweeted
CHIP is a common, age-related condition where mutated blood stem cells expand without causing blood disorders. CHIP raises the risk of hematological malignancies, chronic inflammatory diseases (like heart & lung disease), & lung cancer. This manuscript shows that CHIP somatic clones in blood—especially TET2 mutant ones—migrate into tumors, reshape immunity, drive progression, and promote recurrence. The ability of a somatic clonal expansion in the hematopoietic compartment, to regulate malignant progression in another tissue represents a new perspective in cancer biology. #CHIP #LCMS #cancer #biology #AACR25 nejm.org/doi/full/10.1056/NE…
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies: cell.com/immunity/fulltext/S…
Amazing collaboration led by @CR_UK funded @QuezadaLab @galvez_cancino @uclcancer and colleagues!
Quezada Lab retweeted
Happy Post Doc Appreciation Week! Our facilities are used by Post Docs at @uclcancer, @kingsmedicine, @QMBCI and @TheCrick.
We spoke to Alex Simpson in @QuezadaLab at @uclcancer about life as a Post Doc.
linkedin.com/feed/update/urn…
#CelebratePostDocs
Looking fwd to a great conference!!!
Good and Bad CD4 T-cell Help:
Cornelis JM Melief, Sergio Quezada, and Robert D. Schreiber will address this topic in a plenary session at the AACR Special Conference on Tumor Immunology and Immunotherapy (October 18-21, Boston).
bit.ly/4chsUVi
#AACRtii24 @squezadd
Tremendous line up of speakers! Come join us in Boston!
Submit an abstract by August 5 for the AACR Special Conference on Tumor Immunology and Immunotherapy (October 18-21, Boston), chaired by Yvonne Y. Chen, Sergio Quezada, Robert D. Schreiber, and Fernando Vidal-Vanaclocha. Learn more:
bit.ly/3KLSe9M
#AACRtii24 @squezadd
