@Blake_Hill_Lab

Interdisciplinary team seeking to understand how proteins regulate mitochondrial homeostasis in healthy and diseased cells

 Medical College of Wisconsin
sites.google.com/site/hillbiologylab/home?authuser=0
Joined February 2020
  • Tweets97
  • Following135
  • Followers168
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Blake Hill Lab retweeted
Shuichi Onami@sonamix6 Jan 2024
Image.sc LIVE around the world! Jan 18(Euro, Africa, America) -19(Asia, Aus, NZ). You can chat directly with bioimage analysis experts in your time zone! Post your question ideally before Jan 11, and they will match you with the best person. forum.image.sc/t/image-sc-li…
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New in JBC press: "Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission." Learn more: jbc.org/article/S0021-9258(2…
Figure 1. Fis1ΔN can bind a synthetic peptide version of the Fis1 N-terminal arm.

ALT Figure 1. Fis1ΔN can bind a synthetic peptide version of the Fis1 N-terminal arm.

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Pleased to announce that my PhD thesis work in @Blake_Hill_Lab on structural mechanisms governing vertebrate FIS1 function is finally out in JBC. sciencedirect.com/science/ar… 🧵a thread
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New Hill lab publication from @kanolden and @M_Cleland out in @jbiolchem investigating a long-standing question in mitodynamics in which they show that human Fis1 directly interacts with Drp1 to promote mitochondrial fission! jbc.org/article/S0021-9258(2…

Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochon...

Mitochondrial fission protein 1 (Fis1) and dynamin-related protein 1 (Drp1) are the only two proteins evolutionarily conserved for mitochondrial fission, and directly interact in Saccharomyces...

jbc.org
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These results suggest reciprocal interactions between the Fis1 arm and conserved surface are important for Drp1 recruitment and mitochondrial fission. (9/10)
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Ultimately, our data support a direct Fis1-Drp1 interaction, in which the Fis1 arm may (via a kinetic effect) occlude the binding site. This interaction promotes mitochondrial fission and suggests the yeast and human proteins are more similar than previously thought. (10/10)
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Blake Hill Lab retweeted
Kelsey Nolden@kanolden20 Oct 2023
Excited to share that my thesis work and the latest from @Blake_Hill_Lab in which we found human Fis1 maintains an evolutionarily conserved, direct interaction with Drp1 is now out on JBC! #mitochondria jbc.org/article/S0021-9258(2…

Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochon...

Mitochondrial fission protein 1 (Fis1) and dynamin-related protein 1 (Drp1) are the only two proteins evolutionarily conserved for mitochondrial fission, and directly interact in Saccharomyces...

jbc.org
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Blake Hill Lab retweeted
Robert Haase@haesleinhuepf5 Aug 2023
I'm now officially hooked on #LLMs for #BioImageAnalysis presuming they will do my job one day. Welcome BIA-Bob! 🔬🖥️🤖 github.com/haesleinhuepf/bia…
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Set of #mitochondria now united with their owner Dr @kanolden. Cherry, oak, walnut and padauk woods.
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Blake Hill Lab retweeted
Kelsey Nolden@kanolden25 Apr 2023
Its official (as of a week ago)! So thankful for my experiences in the @Blake_Hill_Lab the last several years and for having @_Blake_Hill as a mentor #PhinisheD #MCWMSTP
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Congrats to Dr. Kelsey Nolden on the successful completion of her PhD!! Now time for the celebration!
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Blake Hill Lab retweeted
Kelsey Nolden@kanolden18 Apr 2023
Defending my PhD dissertation tomorrow! DM for Zoom info if interested in attending virtually.
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Blake Hill Lab retweeted
Kelsey Nolden@kanolden30 Mar 2023
Had such a great week at @StJudeResearch learning about their facilities, programs, and ongoing research as well as sharing some of our lab's own research! #StJudeNGSS
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