Immunologist: Pepper Lab, University of Washington, Seattle WA. Views are my own. The world is talking, listen sometime 🌍
Seattle, WA
Joined August 2012
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Why and How Vaccines Work: Cell cell.com/cell/fulltext/S0092…
Kurt B. Pruner, Ph.D. retweeted
Just out @Nature
Nasal vaccines for respiratory infections
Best review I've seen on this important topic and a big unmet need
nature.com/articles/s41586-0…
Kurt B. Pruner, Ph.D. retweeted
“The attack on some of us is an attack on all of us, and we must stand together.”
-Danny Altmann & me in @NatRevImmunol on why everyone in the world needs to care about the destruction of American scientific & public health capacity. If you think it doesn’t impact you, you’re wrong.
Kurt B. Pruner, Ph.D. retweeted
Delighted to have our Perturb-multiome paper, led by @jmartinrufino and #AlexisCaulier from our lab, published today in @ScienceMagazine. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: science.org/doi/10.1126/scie…
Kurt B. Pruner, Ph.D. retweeted
As trust in vaccines & scientific research becomes political in DC & anti-vaxxers like RFK Jr. are elevated to key roles in the federal government, I joined experts, doctors, & parents in Seattle today to talk about the importance of vaccines to keep families safe & healthy.
ALT Senator Murray is on the right side of the frame with her back to the camera. She is looking at and talking with two women in white lab coats. There are people working a TV camera and photo camera standing behind them.
ALT Senator Murray is sitting at a large wood table with blue gradient signs behind her that say, "Vaccines Save Lives." There are white tent name cards on the table.
ALT Senator Murray is on the left of the frame, sitting at a wood table, and looking to her right where two women are seated. There are microphones on the table and white tent name cards. The wall behind the Senator has blue gradient signs that say, "Vaccines Save Lives."
ALT Senator Murray is on the right of the frame, facing the left, and sitting at a wood rectangle table. Four other women are sitting around the table. The wall behind the Senator has blue gradient signs that say, "Vaccines Save Lives."
Kurt B. Pruner, Ph.D. retweeted
.@MirandaLyCo, Shamskhou, & @MichaelYGerner show that early Th2 cell differentiation is driven via prolonged T–DC macro-clustering in lymph nodes and occurs in a skin site-specific manner. hubs.la/Q02vxYB70
From our #Immunology collection: hubs.la/Q02vy6rN0
#AAI2024
Kurt B. Pruner, Ph.D. retweeted
Our latest work is out @ImmunityCP ! Find out how we used surface proteome analyses to explore circulating and tissue-resident memory T cells diversity across tissues & many more!👇
authors.elsevier.com/c/1hL2j…
@LMackayLab @TheDohertyInst #teamTRM 🧪🔬🧵
Thank you @SantoshVardhana , From an Immunologist who believes in the current and future faculty of vaccination as a powerful technology to improve human health, I have been hesitant to get the words right to speak out and support the continued importance of our work. @PeterHotez
I’ve tried and failed to contain my fury at @joerogan and @RobertKennedyJr's recent craven clickbait podcast episode featuring tired reruns of disproven tropes about the dangers of the COVID-19 mRNA vaccine.
Kurt B. Pruner, Ph.D. retweeted
As scientists, we often forget just how cool our work is. I showed my parents what I do in lab for the first time today & my mom was amazed just looking at DNA on a agarose gel & human cells under the microscope. Take a moment to be proud of yourself & your science!
Kurt B. Pruner, Ph.D. retweeted
(1/5) Special collection this month on #macrophages in tissues! Collection of 4 reviews, focusing on gut, lung, heart, and liver macrophages. cell.com/issue/S1074-7613(21…
Kurt B. Pruner, Ph.D. retweeted
Check out our new preprint examining the roles of pro- and anti-inflammatory cytokines IFNg & IL-10 during SARS-CoV-2 infection of NHP. IL-10 limits early T cell expansion while promoting the formation of airway Trm cells. Amazing job by @TcellScientist!
biorxiv.org/content/10.1101/…
Kurt B. Pruner, Ph.D. retweeted
How do different routes of #mRNA vaccination (made by @Tibabiotech) impact the differentiation and distribution of #vaccine elicited CD8 and CD4 T cell memory responses in mice? @TwiterlessBuck @Masopust_Vezys @niaidcivics
👇🏼
biorxiv.org/content/10.1101/…
Kurt B. Pruner, Ph.D. retweeted
Ulla Buchholz has developed a SARS-2 pediatric vaccine candidate that's incredibly protective in macaques.
A single intranasal delivery induces mucosal Abs and huge frequencies of Trm in the airway.
Beautiful work by Cyril Le Nouën and @TcellScientist
biorxiv.org/content/10.1101/…
nature.com/articles/s41586-0…
I remember this story being compiled when I rotated in @PrlicLab lab a few years ago. So happy to see these brilliant authors in @Nature. Congrats Florian, Jami, Martin and all others involved on a fantastic body of work. 🎉
Kurt B. Pruner, Ph.D. retweeted
On Friday, April 8, join us for Virtual #ScienceFriday, where you'll learn about BRI's latest research into Down syndrome and autoimmunity, as well as COVID-19 immunity, from Drs. Bernard Khor (left) and @peter_morawski. Register by 4/5: bit.ly/2G9QtFh #ScienceEducation
Kurt B. Pruner, Ph.D. retweeted
There may be a longer tail of circulation after the peak (as seen in South Africa), but a rough expectation would have an equivalent number of cases in the next 4 weeks on the other side of the peak. This would suggest 36-46% of the US infected by Omicron by mid-Feb. 7/9
Cannot wait to dive into this. This type of effort from authors to allow others to seamlessly utilize their impressive datasets is selfless and honorable. Will help lots of other investigators help make new and important hypotheses within their own spheres of research! Thank you!
📢 Together with @KC_DC_01 we made a super cool portal for anyone to navigate the data @CellCellPress: livercellatlas.org/ This means you can take any UMAP from any figure and then check the expression of any gene or protein of interest yourself 1/2 cell.com/cell/fulltext/S0092…
Kurt B. Pruner, Ph.D. retweeted
New review from @LabDacand @JMarchingo- how do T cells balance energy requirements, protein synthesis and degradation processes during an immune response? nature.com/articles/s41423-0…
When I try to look up the review I wrote with @PepperMarion on google, and AI thinks I am looking for something entirely different...
...and now I am an expert in pruning peppers AND CD4 T Cells. Thanks, Marion.
