a community of computational protein engineers and modelers from both academia and industry an @openmsf project organized by @bahl_lab @nickpolizzi_ @sokrypton
Boston
Joined March 2020
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Boston Protein Design and Modeling Club retweeted
The Institute for Protein Design is hiring postdocs! 🧬
We design new proteins to tackle big challenges in medicine, sustainability & technology.
Interested in joining our interdisciplinary environment?
Learn more here: ipd.uw.edu/join-us/
Boston Protein Design and Modeling Club retweeted
I have postdoc positions available to lead two new exciting projects! One is on in situ protein sequencing (collab with Ed Boyden at MIT) and the other is on modeling cryptic pockets for drug discovery (collab with Scripps and MGH). Reach out if interested! Details below
If you missed @Jody_Mou's terrific seminar back in March where she presented a bunch of unpublished data from her work in @PolizziLab, you can finally get all caught up 👇
youtu.be/SdkBhhBWZWk
and pre-print: doi.org/10.64898/2026.09.27.…
If you missed the superb lecture last week by @ChristofferNorn, have no fear because you can check out the recording 👇
youtu.be/czkQXg0wwrw
Boston Protein Design and Modeling Club retweeted
Excited to share a preprint of my main PhD work in @nickpolizzi_'s lab - introducing LUCI-tag, a new orthogonal self-labeling protein tag based on K-Ras(G12C) and its covalent inhibitors! biorxiv.org/content/10.64898… (1/16)
quick reminder to join us at DFCI tonight to see @ChristofferNorn!
We moved our next meeting up by 2 weeks so @ChristofferNorn can come present while he's in town! Join us on Wednesday, September 30th 2026 at 7pm EDT in Room 6055, Longwood Center, @DanaFarber
"De novo design of miniproteins targeting GPCRs"
bpdmc.org
Boston Protein Design and Modeling Club retweeted
Time to put that BindCraft2 multi targeting and custom loss implementation to good use!
Run now on AriaX, Tamarind, or via Google Colab and our Github:
In BC2 by Erik Mäeots
github.com/PacesaLab/BindCra…
BC1 version by Lennart Nickel and Paul Kittner:
github.com/martinpacesa/Bind…
We're launching Challenge 1 of the Anthropic x Adaptyv Protein Design Competition on @proteinbase: design a conditional binder to EGFR, a key cancer target.
The goal: bind EGFR under the acidic conditions of the tumor environment, but not at the normal pH around healthy cells. Moreover, the proteins must bind to both the human and the mouse variant of EGFR to support easier preclinical testing
Boston Protein Design and Modeling Club retweeted
Do you use self-labeling proteins (SLPs) like HaloTag and SNAP-tag? Then check out Jody's new preprint to learn about LUCI-tag! Jody built LUCI-tag starting from K-Ras(G12C), using protein design to erase K-Ras from biology 🤯!
Excited to share a preprint of my main PhD work in @nickpolizzi_'s lab - introducing LUCI-tag, a new orthogonal self-labeling protein tag based on K-Ras(G12C) and its covalent inhibitors! biorxiv.org/content/10.64898… (1/16)
If you missed Natasha Murakowska's really great seminar the other week, don't fret as you can check out the recording 👇
youtu.be/tjAPYPpQylo
Boston Protein Design and Modeling Club retweeted
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use.
We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition.
github.com/PacesaLab/BindCra…
We moved our next meeting up by 2 weeks so @ChristofferNorn can come present while he's in town! Join us on Wednesday, September 30th 2026 at 7pm EDT in Room 6055, Longwood Center, @DanaFarber
"De novo design of miniproteins targeting GPCRs"
bpdmc.org
Boston Protein Design and Modeling Club retweeted
We always strive for our work to substantially benefit the greater scientific community, and it's such a thrill every time it happens. A massive thank you to @Addgene for amplifying the impact of researchers everywhere!
🧵👇
If you missed @jeffreyjgray's wicked awesome seminar back in February where he presented a ton of unpublished data, don't worry because you can finally get all caught up 👇
youtu.be/hJqgu2amqI0
Quick reminder to join us at @MIT tonight to see Natasha Murakowska give a great talk!
Come join us on Wednesday, September 9th 2026 at 7pm EDT in Room 181, Building 68, @MIT to see Natasha Murakowska from @AAlphaBio!
"Quantitative Affinity Data at Scale: Addressing the Data Bottleneck in AI-Enabled Protein Design"
bpdmc.org
Come join us on Wednesday, September 9th 2026 at 7pm EDT in Room 181, Building 68, @MIT to see Natasha Murakowska from @AAlphaBio!
"Quantitative Affinity Data at Scale: Addressing the Data Bottleneck in AI-Enabled Protein Design"
bpdmc.org
If you weren't able to make it out for Jeffrey Chang's marvelous seminar this week, you can check out the recording 👇
youtu.be/q3Xn2-TIZEo
Boston Protein Design and Modeling Club retweeted
Happening tonight! Come join in person or on zoom to hear Jeffrey talk about his work. Questions from zoom audience encouraged! bpdmc.org/schedule
Quick reminder to join us tonight at DCFI for a super exciting talk by Jeffrey Chang!
Next week, Jeffrey Chang from @nickpolizzi_'s lab will present a pre-print that just came out today!
Wednesday, August 12th 2026, 7pm EDT in Room 6055, Longwood Center @DanaFarber
"De novo design of small-molecule-induced conformational change"
bpdmc.org
Boston Protein Design and Modeling Club retweeted
The data, code, and detailed protocols are all available on github
github.com/aiproteins/high_t…
and all the plasmids are available on addgene
addgene.org/233685/
addgene.org/233686/
addgene.org/kits/bahl-sumo-p…
