Full Prof, AD Educ & Training @LombardiCancer. #lobular, HER2+/ER+ BrCa, #nuclearreceptors, #GBM. Co-founder @NR_IMPACT. @profriggins.bsky.social she/her
Washington, DC
Joined June 2014
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- Following2K
- Followers2.6K
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Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
Do you use Hallmark_Estrogen_Response_Early/Late signatures from MSigDB? Then try out more comprehensive signatures such as ones we generated from gene expression changes across 66 RNA-seq and 80 microarray experiments e.g. LI_ESTROGENE_META_E2_RESPONSE_UP
gsea-msigdb.org/gsea/msigdb/…
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
Woohoo! Our latest preprint, from @Madhura0327 Nijsure, is out today @biorxivpreprint!
YAP regulates periosteal expansion in fracture repair.
biorxiv.org/content/10.1101/…
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
🎯 Thrilled to share our new paper in collaboration lead by @AlirezaMashaghi and Team on the Androgen Receptor with a key role in the pathophysiology of spinal and bulbar muscular atrophy (SBMA, Kennedy's disease) due to polyglutamine expansions 🧩 @AlbaJimP1 @Andrea_AlegreM
Delighted to share our data on the conformational dynamics of the human #androgen #receptor and its #polyglutamine-expanded variant. We propose a structural mechanism for spinal and bulbar #muscular atrophy.
biorxiv.org/content/10.1101/…
#IDP #Disordered #Protein #SBMA #Neurology
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
Super excited to join this program with an amazing legacy of current and past Fellows!
I am so thankful for those who supported my application, and I look forward to making the most of this wonderful opportunity and engaging with the vibrant and diverse Keystone community!
We are pleased to announce our new #KSFellows class of 2025, which features exceptional scientists from diverse backgrounds who will become tomorrow’s research leaders! Read more about these rising stars in the Keypoint Newsletter! #DiversityinScience
hubs.la/Q030yFsp0
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
I am excited to share our work in @JMolBiol, which is our 7th publication on #nuclearreceptors for the 2024 calendar year! Please read on for a summary of all 7 publications from our lab this year, as well as links to the papers.
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
The LEANORA study: Understanding the pharmacokinetics and pharmacogenomics of ribociclib in black women
@MaxPGx @SandraSwainMD
communities.springernature.c…
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
Just Published to close off the year! Our latest work explores the dynamic interplay between ER and HER2 in breast cancer, revealing how treatment drives receptor discordance and impacts clinical outcomes. @CancerCentreIre @RCSI_Irl @RCSIPharmBioMol
onlinelibrary.wiley.com/doi/…
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
Always good to see TBIO Alumni out & about irl! 🎉
Great running into you Apsra Nasir (front, TBIO MS & TBIO PhD), @AileenIlianaPhD Fernandez (she/her/hers) (left, UDC/LCCC MS & TBIO PhD), & Jamie Holloway, PhD (right, TBIO PhD) at @SABCSSanAntonio 2024
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
This is such an unacceptable response for an NIH PD to give to a trainee. For the record she did read the notices and discuss with her mentor (me), and I recommended she reach out and ask. Wonder why talented young people are leaving academia? This is why @NIH 😑
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
🎯 Read the new amazing research from the labs of Gordon Hager & Frank Dequiedt lead by @GregoryFettweis @WaghKaustubh #DianaStavreva @AlbaJimP1 & rest of collaborators. Always a great pleasure working with these team of awesome scientists 🪐✨️
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
We got another grant rejection today but I remain unfazed. I know where I started and the impact I’ve had already, and I know the impact I will have going forward.
If I required others to see my potential and my vision to forge ahead, I’d have stopped long ago.
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
Our work on metabolism of quiescent cells! A bit of a new area for us in collaboration with the Buckanovich lab
New research reveals that #acetate drives quiescence in ovarian #cancercells by boosting ACSS2-mediated acetyl-CoA production. High ACSS2 levels are linked to poor patient outcomes and #chemoresistance.
Targeting ACSS2 could enhance treatment response!
🔗sciencedirect.com/science/ar…
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
We’re thrilled to share our Nature Methods review on #CellPainting — your go-to resource for mastering Cell Painting! From MOA and toxicity prediction to contributing to candidate drugs in clinical trials, we’ve distilled 10 years of insights!
Free link: rdcu.be/d2vHH
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
I am incredibly grateful for this recognition! To be listed among scientists who have made indelible marks of pioneering advancements --- what a humbling experience!
"Cancer genomicist Melissa B. Davis on surrounding yourself with supportive mentors and allies"
Read our interview with @MSMEDU Dr. Melissa B. Davis, one of our #50ScientistsThatInspire:
cell.com/news-do/50-inspirin…
ALT Quote from Dr. Melissa B. Davis: "It’s crucial to find a network of people who support, protect, and encourage you."
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
Congratulations to Steffi Oesterreich, PhD, this year’s recipient of the AACR Distinguished Lectureship in Breast Cancer Research. Dr. Oesterreich will present her award lecture at #SABCS24 on December 12. bit.ly/3YTGkBg @UPMCHillmanCC @SABCSSanAntonio
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
I am immensely proud of Steffi for receiving this award for her breast cancer research, particularly #lobular. She has dedicated her career to this goal and paid special attention to trainees and the involvement of advocates. See her talk at @SABCSSanAntonio #BCSM
Congratulations to Steffi Oesterreich, PhD, this year’s recipient of the AACR Distinguished Lectureship in Breast Cancer Research. Dr. Oesterreich will present her award lecture at #SABCS24 on December 12. bit.ly/3YTGkBg @UPMCHillmanCC @SABCSSanAntonio
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
There are only two days left to apply to #FLARE2025 (bit.ly/2N5iKxV) and #ExCEL2025 (bit.ly/3waSFCh)! These prestigious leadership programs provide a unique opportunity to develop professional skills, connect with experienced mentors, and advance your career in endocrinology. Applications are due by Monday, November 18, at 11:59 PM ET.
Dr. Rebecca B. Riggins 🇻🇮👩🏻🔬⛵️ retweeted
Glad to share our study in npj Precision Oncology nature.com/articles/s41698-0…, where we cross-compared transcriptomes and immune infiltration in ILC tumors, building on work by @OnkarSayali (nature.com/articles/s43018-0…). Our findings reveal a proliferative subtype linked to increased suppressive immune infiltration, and a signature characterized by lower proliferation, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer.
Great appreciations to co-authors Drs. Sayali Onkar @OnkarSayali, Jian Zou, Yujia Li, Haley Arbore @haley_arbore00, Sai Maley, George Tseng, Peter C. Lucas, Tullia C. Bruno @BcellBruno, Dario A. Vignali @Vignali_Lab, Julia Foldi @JuliaFoldiMD, Marija Balic, and especially mentors Drs. @Adrianvlee & @oesterreichs for their invaluable support, expertise, and contributions.
#BreastCancer #ImmunoOncology #PrecisionMedicine #CancerResearch #ERPositive #LobularCancer #Oncology
