@ProfBalog

associate professor of chemistry @unetweets. protein biochemistry, biophysics, biomaterials. mom of three. https://xitter.cf/t.co/z1ZjNWVoFc

 Biddeford, ME
etsy.com/shop/AtelierBiochimie
Joined August 2014
  • Tweets2.1K
  • Following352
  • Followers412
83Media
Researchers - have you considered using engineered protein binders as an alternative to tradtional antibodies for Western blots, fluorescence microscopy, etc? Interested in the practical barriers to general adoption of AI-engineered binders for research
20
23
1
193
33,209
Proud to share a new manuscript: "Ensemble docking for intrinsically disordered proteins" from @DartmouthChem undergrad Anjali Dhar 24' and grad student Tommy Sisk. We present ensemble docking strategies for IDPs that, remarkably, seem to work! (Links in thread below)
6
58
2
290
30,138
The Garden Grants application window is open! We're offering $50k-$150k grants (up to $1M total) to support de-risking ideas that intersect biology and GHGR. Application window closes 2/28. Apply here: homeworld.bio/grants-greenho…

Garden Grants GHGR — Homeworld Collective

Garden Grants: Funding to grow climate biotech

homeworld.bio
1
7
3
10
3,789
Today, I would like to honor the memory of Roger Y. Tsien, born on February 1, 1952. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! nature.com/articles/nmeth.40… #FluorescenceFriday
3
54
2
290
21,095
Eva Rose Balog retweeted
nature
@Nature21 Jan 2025
Obituary: Martin Karplus (1930-2024) theoretical chemist who first simulated proteins using molecular dynamics go.nature.com/40s9ckO

Martin Karplus obituary: theoretical chemist who first simulated proteins using molecular dynamics

Nature - The Nobel prizewinner used quantum and molecular mechanics to model the dynamics of complex chemical systems.

nature.com
3
36
6
149
23,340
Eva Rose Balog retweeted
J. Am. Chem. Soc.@J_A_C_S29 Jan 2025
Modulation of Protein–Protein Interactions with Molecular Glues in a Synthetic Condensate Platform | Journal of the American Chemical Society @TUeindhoven pubs.acs.org/doi/10.1021/jac…

Modulation of Protein–Protein Interactions with Molecular Glues in a Synthetic Condensate Platform

Abstract. Misregulation of protein–protein interactions (PPIs) underlies many diseases; hence, molecules that stabilize PPIs, known as molecular glues, are

pubs.acs.org
6
1
33
4,688
Eva Rose Balog retweeted
Dr. J. M. Groh@JMGrohNeuro23 Jan 2025
If you had a study section or similar NIH travel canceled, or indeed if you have not, can you reply with the dates of the meeting and whether it's on or not? Would be good to get a sense of what time period this applies to for now (esp if NIH is muzzled and can't announce it...)
STAT
@statnews23 Jan 2025
A flurry of scientific gatherings and panels across federal science agencies were canceled on Wednesday, at a time of heightened sensitivity about how the Trump administration will shift the agencies’… trib.al/GbxnMtw

Trump administration’s abrupt cancellation of scientific meetings prompts confusion, concern

A flurry of scientific gatherings and panels across federal science agencies were canceled on Wednesday, at a time of heightened sensitivity about how the

statnews.com
11
23
85
29,164
Every synthetic biologist, every biochemist, when they dream, will sometimes hear a voice calling A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods "Engineer RuBisCo" And this paper takes us one step closer nature.com/articles/s41586-0…

A map of the rubisco biochemical landscape

Nature - A massively parallel assay developed to map the essential photosynthetic enzyme rubisco showed that non-trivial biochemical changes and improvements in CO2 affinity are possible,...

nature.com
14
123
14
675
46,321
I've never seen anything quite like this, very cool
J. Am. Chem. Soc.@J_A_C_S16 Jan 2025
Observation of the Protein-Inorganic Interface of Ferritin by Cryo-Electron Microscopy | Journal of the American Chemical Society @ASU @ASUBiodesign @ASUResearch pubs.acs.org/doi/10.1021/jac…

Observation of the Protein-Inorganic Interface of Ferritin by Cryo-Electron Microscopy

Abstract. Visualizing the structure of the protein-inorganic interface is critically important for a more complete understanding of biomineralization. Unfo

pubs.acs.org
18
Eva Rose Balog retweeted
nature
@Nature6 Jan 2025
Those recovering from drug or alcohol misuse speak up — and say they wish more researchers could do so freely at work nature.com/articles/d41586-0…
2
2
1
18
13,788
I'm very happy to announce that I have retired! I'm equally happy that @janetiwasa has agreed to continue the Molecule of the Month @buildmodels. Read about this at cdn.rcsb.org/rcsb-pdb/genera…

EDUCATION CORNER: Molecule of the Month: Celebrating  25 Years of Storytelling and Announcing New...

After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month series.  Janet Iwasa will be continuing the series for PDB-101.

cdn.rcsb.org
31
64
8
496
26,174
Failure to establish a reasonable digital folder hierarchy
love drops
@lovedropx30 Dec 2024
People in their 40s, what’s something people in their 20s don’t realize is going to affect them when they age?
1
2
24
3,823
Eva Rose Balog retweeted
Michael Fischbach
@mfgrp11 Dec 2024
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
15
244
65
1,017
231,991
Check out this @SpecificaInc AI challenge (co-authored by André Teixeira, now at IPI) on #antibody affinity maturation, #affinity rank prediction for Ab discovery, and computational antibody design! @NatureBiotechl #proteinscience nature.com/articles/s41587-0…

AIntibody: an experimentally validated in silico antibody discovery design challenge

Nature Biotechnology - AIntibody: an experimentally validated in silico antibody discovery design challenge

nature.com
1
1
211
Tag yourselves.
graphomania | noun | a compulsive urge to write

ALT graphomania | noun | a compulsive urge to write

27
167
38
948
51,489
Can protein expression be "solved"? And how can we enable predictive design? Check out this project led by @erika_alden_d @Align_Bio zenodo.org/records/13940346

Can protein expression be "solved"?

Recombinant protein expression is central to biotechnology’s application in academic exploration as well as human health, climate applications and the bioeconomy in general. However, not all proteins...

zenodo.org
2
29
124
10,871
absolutely thrilling protein design - for its findings, applications, and most of all future questions. This is how you play all day.
Adam Broerman@adam_broerman17 Nov 2024
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.1101/…
1
93
interesting metabolic biochemistry *and* pictures of bats on a treadmill
Alexander Schubert
@alexschbrt9 Nov 2024
Vampire bats literally run on blood. Their body can oxidize non-essential amino acids from blood meals to rapidly create ATP, fueling their muscles. royalsocietypublishing.org/d…
1
1
83
from the link: Photographs by Price Sewell.
28
Eva Rose Balog retweeted
nature
@Nature4 Nov 2024
Tools such as Rosetta and AlphaFold have redefined the protein-engineering landscape. But some problems remain out of reach — for now go.nature.com/3YT7zgN
3
122
4
395
39,205
Load more