@ProPepChem

Tweets about all things related to protein and peptide chemistry

Joined March 2017
  • Tweets420
  • Following276
  • Followers951
3Media
Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging | Journal of the American Chemical Society @KingsCollegeLon pubs.acs.org/doi/10.1021/jac…

Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward...

Abstract. Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is the formation of

pubs.acs.org
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Chemical protein synthesis, folding and purification in a day from @PenteluteLab pubs.acs.org/doi/epdf/10.102… @J_A_C_S

Same Day Access to Folded Synthetic Proteins

Abstract. Understanding protein function is a cornerstone of modern biology. Research centers worldwide dedicate significant efforts to prepare individual

pubs.acs.org
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Awesome 🙌🏾 pubs.acs.org/doi/10.1021/jac…

Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis

Abstract. Chemical mutagenesis via dehydroalanine (Dha) is a powerful method to tailor protein structure and function, allowing the site-specific installat

pubs.acs.org
ManuelMuellerLab@lab_mueller2 Aug 2024
Thrilled to highlight our work on chemoenzymatic protein modification, recently published in @J_A_C_S : Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis | Journal of the American Chemical Society (acs.org)
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Native chemical ligation enhanced by a capture step performed in TFA - interesting tactic for solubilising peptide fragments followed by ligation science.org/doi/epdf/10.1126… @ScienceAdvances
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Cyclic peptides via direct aminolysis of acyl azides in organic solvents @J_A_C_S pubs.acs.org/doi/10.1021/jac…

Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases

Abstract. Nonribosomal cyclic peptides (NRcPs) are structurally complex natural products and a vital pool of therapeutics, particularly antibiotics. Their

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Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in @J_A_C_S! We used flow-SPPS to synthesize several sidechain- and backbone-modified precursor peptides and demonstrated their in vitro transformation. pubs.acs.org/doi/10.1021/jac… @UZH_Chemistry @Hartrampf_Lab

Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides

Abstract. Many peptidic natural products, such as lasso peptides, cyclic peptides, and cyclotides, are conformationally constrained and show biological sta

pubs.acs.org
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Review on non-symmetric stapling strategies for peptides @NatRevChem nature.com/articles/s41570-0…
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📣 We have 3️⃣ open PhD positions in chemical protein synthesis on our SNSF Sinergia project „MYConnect“ 🧫🧪 Please apply as soon as possible via jobs.uzh.ch/offene-stellen/3… We look forward to exploring MYC phosphorylation with @ZerbeOliver and Linda Penn! Thank you @snsf_ch 🙏
UZH Chemistry@UZH_Chemistry13 Nov 2023
We are hiring 👋: @NinaHartrampf and @ZerbeOliver @UZH_Chemistry: chem.uzh.ch/de/study/theses.… for our new SNF Sinergia Projcet: MYConnect – deciphering phosphorylation-dependent MYC interactions in cancer biology
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iLYTACS: Authors leverage IGF-2 fusions to affibodies or nanobodies for targeted degradation pubs.acs.org/doi/abs/10.1021…  @J_A_C_S

Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extrace...

Abstract. Targeted degradation of the cell-surface and extracellular proteins via the endogenous lysosomal degradation pathways, such as lysosome-targeting

pubs.acs.org
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We have a postdoc position available @ChemistryUoN to further develop our visible-light-mediated bioconjugation chemistry! Funded by @LeverhulmeTrust until April 2026. RT appreciated! jobs.nottingham.ac.uk/vacanc…

Jobs at the University of Nottingham

jobs.nottingham.ac.uk
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Interesting report in JACS where C-terminal hydrazides can be converted to SAL esters for Ser/Thr Ligation (STL) - pubs.acs.org/doi/pdf/10.1021…
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📢Exciting new PhD opportunity to join the Baker Group and investigate new Bioorthogonal Click Reactions. Further information linked. Deadline 20/07/23. 🥼 findaphd.com/phds/project/in…

Investigating New Biorthogonal Click Reactions at University College London on FindAPhD.com

PhD Project - Investigating New Biorthogonal Click Reactions at University College London, listed on FindAPhD.com

findaphd.com
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ProPepChem retweeted
Eric Topol
@EricTopol17 May 2023
Here is the link to @davidrliu's outstanding lecture @scrippsresearch. If you want to get up to speed on genome editing, it's all here. dropbox.com/s/8ldbsyp4wrg11w…
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📢 #PeptideLovers Registration for German Peptide Symposium is out📢 Excellent speakers: 😎🤩Suga, @bode_lab @SafaviLab Rauser @NeundorfLab Sebeeck, Riniker Weingart @KawamuraGroup Granja, Seitz & more. Join us in #Jena Send 🧑‍🔬 80 EUR registration!We'll be there. Please RT♥️🙏 – at Kirchdorf an der Iller, Deutschland
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I am happy to share that our manuscript on #thioester reactivity is now out in @JACS_Au. Big thanks to @SabrinaHelenaa, @BejderBenjamin, and my former PhD student and now co-corresponding author @BengtGless 👏 @UCPH_health @UCPH_CBP pubs.acs.org/doi/pdf/10.1021…
Thioester reactivity by FRET assay from Olsen Lab UCPH

ALT Thioester reactivity by FRET assay from Olsen Lab UCPH

Christian Adam Olsen@ChristianAOlsen28 Mar 2023
New preprint on @ChemRxiv We share a FRET method to rapidly investigate a variety of thioesters under a variety of conditions, thanks to work by @BengtGless and @SabrinaHelenaa. chemrxiv.org/engage/chemrxiv… I am grateful to @LEOFondet for their support💶. @UCPH_health @UCPH_CBP 1/5
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Not long to go… Please submit your nominations for the 2023 AstraZeneca Prize in Protein and Peptide Science by 31st March. Self nominations are encouraged! ⏰
RSC Protein and Peptide Science Group@RSC_PPSG3 Feb 2023
🌟The 2023 RSC #AstraZeneca Protein & Peptide Science Award is now open for nominations!🏆 Please send nominations to Dr Corinne Kay (PPSG Secretary) - details below. Deadline 31st March 2023 @RoySocChem @EurPepSoc #peptides #proteins
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Join us for the virtual March Peptide Social this Thursday to catch up with your international colleagues in an informal setting. ☕️💻 ⏰ If you have not registered yet, but would like to attend, please contact us via email. @EurPepSoc @ampepsoc @AusPeptide @ProPepChem
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Check out our latest review article on synthetic routes to prepare bioactive proteins @angew_chem #ChemicalSynthesis #Semisynthesis #BioactiveProteins onlinelibrary.wiley.com/doi/…

Chemical Synthesis of Bioactive Proteins

Protein chemistry has evolved remarkably in the past decade, which has enabled the effective production of new molecules with novel physicochemical properties for biomedical research, and therapeut...

onlinelibrary.wiley.com
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Histone Lys acetylation has been well studied, however the function of histone O-acetylation on Ser/Thr remains unknown, its reader, writer, eraser? Anyone interested ? We have the modified histone protein .
Angewandte Chemie@angew_chem30 Nov 2022
Chemical Synthesis of Proteins with Base-Labile Posttranslational Modifications Enabled by a Boc-SPPS Based General Strategy Towards Peptide C-Terminal Salicylaldehyde Esters (Li) @LiXuechen_HKU onlinelibrary.wiley.com/doi/…
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ProPepChem retweeted
Malins Lab@Malins_Lab7 Nov 2022
Our latest work on tunable electrochemical peptide modifications is out today in @angew_chem!⚡️Big congrats to PhD student Dhanya @kpdhanya95 for leading this joint @ANUChemistry effort between @connalgroup and @Malins_Lab! Check out the article here: onlinelibrary.wiley.com/doi/…
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