@KorkhovLab
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The @KorkhovLab @ETH_en and @psich_en studies the structure and function of #MembraneProteins involved in signal transduction
Joined November 2021
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The @KorkhovLab has an opening for a student or a scientist displaced from Ukraine. If you are interested or know someone who might be interested - please DM.
Our paper on using adenylyl cyclase 9 as a molecular scaffold to dissect the mechanisms of membrane adenylyl cyclases is out in Protein Science. Great effort by Ilayda Kantarci and Haoriwa! 👇
onlinelibrary.wiley.com/doi/…
Excellent talk today by Roberta Florea - she brought structural proteomics and integrative modelling to the International Gap Junction Conference 2026 in Padua!
Korkhov Lab retweeted
How do cells integrate multiple signals into precise responses? Our study uncovers neuronal calcium sensor proteins as new regulators of adenylyl cyclase 8, linking GPCR/cAMP and Ca²⁺ signaling. @KorkhovLab @psich_en @ETH_DBIOL
biorxiv.org/content/10.64898…
ALT Picture Credit: Roberta Florea
A new twist in the cAMP-Ca2+ signaling crosstalk: Neuronal calcium sensors emerge as novel adenylyl cyclase 8 regulators!
biorxiv.org/content/10.64898…
Membrane Adenylyl Cyclases are tough cookies when it comes to in vitro structure-function studies. Ilayda Kantarci and Haoriwa used a chimeric construct strategy to crack isoform‑specific AC regulation 👇
biorxiv.org/content/10.64898…
Our study on the lipid dependence of Cx32 gap junction channel conformations is now out in @NatureComms. Amazing work by @PLavriha, @FluriCarina, and Jorge Hernández González!
nature.com/articles/s41467-0…
Our manuscript on the distinct mechanisms by which drug-like small molecules target the malaria parasite transporter PfNCR1 is now on bioRxiv 👇
biorxiv.org/content/10.1101/…
Our manuscript exploring the radiation dose effects on protein structure is now online, underscoring the great promise of correlative workflows combining X‑ray tomography with cryo‑EM at high resolution 👇
biorxiv.org/content/10.1101/…
Korkhov Lab retweeted
In collaboration with the Posthaus Lab, we identify ANTXR2—also the anthrax toxin receptor—as the receptor for Clostridium perfringens NetF pore forming toxin. Cryo-EM shows extensive contact between the pore and the receptor #Microbiology #CryoEM doi.org/10.1101/2025.07.02.6…
Our investigation of lipid dependence of Cx32 gap junction channel conformations is now online on @biorxivpreprint. Great work by @PLavriha, @FluriCarina and Jorge Hernández González!
biorxiv.org/content/10.1101/…
Korkhov Lab retweeted
#Authorinterview: Basavraj Khanppnavar a structural biologist and biochemist talks about his work on "Molecular Snapshots Unravel Botox’s Secrets of Nerve Cell Entry". #botox #cryoEM #neuron @BasurajSK @KorkhovLab
@ETH_en biopatrika.com/academia/rese… via @biopatrika
Korkhov Lab retweeted
Happy to share our latest publication on @NatureSMB Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W. nature.com/articles/s41594-0…
nature.com/articles/s41594-0…
thanks @SjorsScheres and @MichelGoed support 🥳🥳🥳
Korkhov Lab retweeted
Want to know “How does #Botox enter neuronal cells at the right time & place to exert its #therapeutic effect?” Check out our latest paper @NatureComms @psich_en @eth_en @ETH_DBIOL @KorkhovLab.nature.com/articles/s41467-0…
Our joint study led by @BasurajSK and Oneda Leka, on the interactions between botulinum neurotoxin BoNT/A1 and its receptor SV2B, is now out in @NatureComms. This was a great collaboration with the group of Richard Kammerer (@psich_en)!
rdcu.be/d9rOL
Korkhov Lab retweeted
Excited to share that I've been elected as member of the "Junge Kolleg" of the Nordrhein-Westfalian Academy of Sciences and Arts. I'm honored to have this opportunity to serve the community! Here's the link to the announcement, unfortunately only in German awk.nrw/news/nachwuchsfoerde…
Korkhov Lab retweeted
Honored to have received the #ForWomenInScience #FWIS2024 award. Thanks to #Loreal #LorealGroup #UNESCO, the selection committee, the organizers of the amazing ceremony and to my family that supports me doing science!
#StopTheDropout #EqualOpportunity #WomenEmpowerment
Korkhov Lab retweeted
Authors from @Gschertler lab, @psich_en report structures of an activated bistable opsin, a bidirectional photoswitch.
nature.com/articles/s41467-0…
Korkhov Lab retweeted
Captain Aureispira - a bacterial pirate ship🦜🏴☠️🪝- boarded @ScienceMagazine. Check out the manuscript here: science.org/doi/10.1126/scie… and have a look on our extended thread below ⬇️We provide new insights on bacterial predation from molecules ⚛️to ocean samples 🌊
Bacteria can be pirates too... 🏴☠️ Let us introduce you to Captain Aureispira ⛵️ A bacterial pirate ship loaded with canons 💉 and grappling hooks 🪝🌴predating on other bacteria 🦠 Check the preprint: biorxiv.org/content/10.1101/… #predation #T6SS #T9SS #cryoEM #cryoET #teamtomo 🧵1/6
Korkhov Lab retweeted
CryoEM structure of the human Connexin-43 gap junction channel (PDB code: 8QKO) #scivis #molecularart #sciart @dzine_ai @proteinimaging
behance.net/gallery/20914985…
Korkhov Lab retweeted
Our work on the regulation of the gamma-tubulin ring complex is now online @Dev_Cell! Huge congratulations to all co-authors involved! Open access link to the paper: cell.com/developmental-cell/…
