👉Influence of Subclinical Atherosclerosis Burden and Progression on Mortality 👉While both imaging modalities improved the performance of the multivariate model incorporating CVRFs and background medication, carotid VUS performed significantly better than CAC scoring. It would thus appear that, while both imaging techniques improve risk prediction and reclassification based on traditional risk factors, carotid VUS more accurately refines the risk of all-cause mortality. 👉Interestingly, although the percentage of patients with isolated CAC was similar in each FRS category (∼10%), the percentage of patients with isolated carotid disease was substantially higher in the low-FRS group (25%) and decreased with increasing FRS category. This suggests that VUS is a more sensitive detector of subclinical atherosclerosis in individuals assigned a low cardiovascular risk based on CVRFs (in whom conventional scores may underestimate risk) and before the onset of calcification of coronary lesions. 🔓Open Access jacc.org/doi/10.1016/j.jacc.… @society_eas @ACCinTouch @JACCJournals