Pharmaceutical physician & epidemiologist, MD/PhD Genentech. Opinions are my own.
Bay Area, USA
Joined May 2009
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Michael V Holmes (he/him) retweeted
If anyone would like to join the ride for @TimMcKenna01, please get in touch. It's hard to believe this even happened, but it will be so nice to come together and remember Tim, to ride the way he rode, and raise a few quid for Mind. timcyclesthecoast.com/
These are the dates:
Michael V Holmes (he/him) retweeted
Yesterday was a hard day at 23andMe, and we said goodbye to a number of tremendously talented colleagues. If people have job openings in the genetics space that they'd like me to share with the impacted folks, please do post here.
Michael V Holmes (he/him) retweeted
Thank you to our customers and the @23andMeResearch team for this work on the genetics of #longcovid
medrxiv.org/content/10.1101/…
Michael V Holmes (he/him) retweeted
Our blog post on the same work, for the lay reader. blog.23andme.com/articles/ge…
Much-needed data on the genetics of #longCOVID in a new preprint by @23andMeResearch - GWAS of #LongCOVID identified 3 loci pointing to immune and thrombo-inflammatory mechanisms 🔥 @ninaadsc
1) HLA-DQA1–HLA-DQB
2) ABO
3) BPTF–KPAN2–C17orf58
(1/)
medrxiv.org/content/10.1101/…
Michael V Holmes (he/him) retweeted
Much-needed data on the genetics of #longCOVID in a new preprint by @23andMeResearch - GWAS of #LongCOVID identified 3 loci pointing to immune and thrombo-inflammatory mechanisms 🔥 @ninaadsc
1) HLA-DQA1–HLA-DQB
2) ABO
3) BPTF–KPAN2–C17orf58
(1/)
medrxiv.org/content/10.1101/…
Michael V Holmes (he/him) retweeted
📌Publication alert: In a preprint from the @23andMeResearch team, we conducted one of the largest GWAS study of Long COVID and identified genetic links of chronic conditions with Long COVID.
medrxiv.org/content/10.1101/…
Michael V Holmes (he/him) retweeted
🚴🏼♀️In less than 2 weeks I'll be in the saddle towards Barcelona with @DominicFurniss & some colleagues, friends, & his family. #O2B
Why? To raise 💰for @Sarcoma_UK
Why? Have a look here: 👀itv.com/news/meridian/2024-0…
Able to donate? Please do here: 👏🏼justgiving.com/page/cel-o2b
In a preprint from the @23andMeResearch team, we used Mendelian randomization to explore the genetically-predicted causal effects of Lp(a) on a range (n=489) of human traits and diseases.
medrxiv.org/content/10.1101/…
Importantly, levels of Lp(a) are higly genetically regulated, speaking to the need for therapeutics to lower Lp(a) when levels are elevated. This also identifies the value of genetics in identifying individuals who may have high Lp(a) levels.
Michael V Holmes (he/him) retweeted
Previous papers have shown that drug targets with supporting genetic evidence can have twice the success rate when reaching clinical trials. In our most recent paper (medrxiv.org/content/10.1101/…), we looked at how data from @23andMe can provide additional genetic evidence. 🧵1/8
Michael V Holmes (he/him) retweeted
Excited to share what @drsarahhowles @DominicFurniss @mvholmes, collaborators, and I have been working on: medrxiv.org/content/10.1101/…
We used systematic, regional #MendelianRandomisation & #Colocalisation to identify 3 genetic regions where #calcium, #phosphate, & #KSD colocalise.
Genetic variants predisposing to increased risk of kidney stone disease medrxiv.org/cgi/content/shor… #medRxiv
Michael V Holmes (he/him) retweeted
10-year ASCVD risk prediction leads to older individuals being prioritized for statins missing opportunities for earlier risk recognition & prevention.
Our work led by @tigerstatdoc uses genetics & dynamic risk factor trajectories toward intersecting risk *early.* nature.com/articles/s41467-0… @NatureComms
A preprint from the 23andMe Research Team exploring the multi-ancestry genetics of diarrhea during acute Covid in which we find evidence that IBS subtypes influence risk.
Kudos to the 1st author, Ninad Chaudhary @ninaadsc, a postdoc in the Research Team!🙌medrxiv.org/content/10.1101/…
A preprint from the @23andMeResearch Team on the genetic architecture of sporadic and recurrent miscarriage and where we evaluate potential causal effects of modifiable exposures
TL;DR: we identify 11 novel GWAS loci and evidence smoking and caffeine potentially increase risk
Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent Miscarriage medrxiv.org/cgi/content/shor… #medRxiv
A new preprint from The 23andMe Research Team showcasing our capabilities in recall-by-genotype initiatives.
Here we use recall-by-genotype to facilitate enhanced phenotyping in order to characterise a LoF variant in MAP3K15 associated with T2D medrxiv.org/content/10.1101/…
Michael V Holmes (he/him) retweeted
In 2018 we published a non-linear Mendelian randomisation (NLMR) study in @ObesitySociety and it is now clear the method we applied is deeply flawed, so in October we published a Perspective correcting it. A 🧵on the cautionary tale of NLMR onlinelibrary.wiley.com/doi/…
