@PenengoLab

We investigate the role of the ubiquitin and the interferon/ISG15 system in maintening genome stability in response to different types of stress

 IMCR, Zurich, Switzerland
imcr.uzh.ch/en/research/penengo
Joined February 2023
  • Tweets28
  • Following175
  • Followers193
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Lorenza Penengo Lab retweeted
DMMD University of Zurich@DmmdUzh
20 Jun 2024
📢Excited to share the latest work from the Santoro Lab ! A cutting-edge technology reveals the crucial role of the nucleolus in genome organisation. Discover more: biorxiv.org/content/10.1101/… #Genomics #Nucleolus"

Single-cell dynamics of genome-nucleolus interactions captured by nucleolar laser microdissection...

Gene position in the nuclear space plays an important role in gene regulation. This is exemplified by repressive chromatin domains frequently contacting nuclear lamina or nucleoli. The nucleolus...

biorxiv.org
RaffaellaSantoroLab@LabSantoro
20 Jun 2024
New exciting data from the lab! We established nucleolar laser microdissection (NoLMseq) to capture single-cell dynamics of genome-nucleolus interactions in normal and “stressed” nucleoli, providing novel insights into genome organization & function biorxiv.org/content/10.1101/…

Single-cell dynamics of genome-nucleolus interactions captured by nucleolar laser microdissection...

Gene position in the nuclear space plays an important role in gene regulation. This is exemplified by repressive chromatin domains frequently contacting nuclear lamina or nucleoli. The nucleolus...

biorxiv.org
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Lorenza Penengo Lab retweeted
Sidrit Uruci (Sid)@UruciSidrit
23 Jan 2024
So exciting to see this amazing story out!! Glad I could be of help 😁 Huge shout-out to all authors involved 🎉🎉 A highly recommended read for all DSBs and DNA repair aficionaf@s!!
Sylvie Noordermeer@SylvieNoorderm1
23 Jan 2024
It is online! The first paper of the Noordermeer lab. Of course, this wasn't possible without the help of many others (see thread for more details). Congratulations to first authors @BertKooij, Anne Schreuder and @pavani_raphael. sciencedirect.com/science/ar… 1/8
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Lorenza Penengo Lab retweeted
Hubrecht Institute@_Hubrecht
9 Nov 2023
Researchers from the group of @FMattiroli developed a new fluorescence-based assay and used this to identify ANP32B as the histone chaperone responsible for the histone macroH2A. First author @IMandemaker tells all about it here! hubrecht.eu/histones-and-cha…
Microscopy image of human cells stained for macroH2A and DNA.

ALT Microscopy image of human cells stained for macroH2A and DNA.

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Lorenza Penengo Lab retweeted
Arnab Ray Chaudhuri@Arnab_RC1
7 Nov 2023
The final countdown has begun… a week more for the closing of registrations… please register soon as only a few more slots are left🔥👇
Arnab Ray Chaudhuri@Arnab_RC1
31 Oct 2023
Just a few more days to go for the registration deadline- “EMBO workshop on evolution and diversity of the DNA damage response” meetings.embo.org/event/24-d… multiple short talks, & waivers available! 🧬Don’t miss this amazing opportunity to meet with world leaders & journal editors.☄️

Evolution and diversity of the DNA damage response

To cope with the threat of genome instability, cells have evolved an intricate network of mechanisms ranging from cell cycle checkpoints to specialized DNA repair pathways, and collectively known as …

meetings.embo.org
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Lorenza Penengo Lab retweeted
Fabrizio d'Adda di Fagagna@FdAdF66
7 Nov 2023
Happy to share our recent publication identifying a vulnerability in ALT #cancer cells that can be targeted by #telomeric #antisenseoligonucleotides #ASO against #ncRNA induced by #telomere dysfunction. nature.com/articles/s41467-0…

Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs

Nature Communications - ALT cells use an alternative lengthening mechanism of telomeres and bear telomeric DNA damage with increased levels of damage-induced long non-coding RNA. Here the AUs show...

nature.com
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Lorenza Penengo Lab retweeted
Aga Gambus@AgaGambus
20 Oct 2023
We are looking for DNA replication enthusiast to join our group as a postdoctoral researcher. If you are into biochemistry, cell biology, structural biology in replication and damage, please get in touch, or apply - the link below. Closing date 9th November. RT pls
Cancer and Genomic Sciences@IcgsUob
20 Oct 2023
📢Research Fellow wanted to create & contribute to the creation of knowledge by undertaking research specified by BBSRC research grant awarded to @AgaGambus to investigate function of DONSON during DNA replication initiation. shorturl.at/ghnGX
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ONLINE NOW our story on the role of interferon/ISG15 in BRCA contexts! Congratulations to Ramona Moro, @uddipta_biswas, and all the co-authors! A great collaborative effort with Shyam Sharan, @RFreireLab and @Arnab_RC1. nature.com/articles/s41467-0… Thrilled to hear your feedback!

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

Nature Communications - Here the authors show that the basal activation of the interferon/ISG15 pathway is required for the stability of nascent DNA during replication and its upregulation promotes...

nature.com
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Lorenza Penengo Lab retweeted
Raimundo Freire@RFreireLab
28 Mar 2023
Excited to announce our new paper by @EsperanzaHC_ in @NAR_Open, showing a new role for ATXN3 in regulating chromatin structure by controlling the subcellular localization of HDAC3 and thereby giving insight into the molecular basis of SCA3. doi.org/10.1093/nar/gkad212

ATXN3 controls DNA replication and transcription by regulating chromatin structure

Abstract. The deubiquitinating enzyme Ataxin-3 (ATXN3) contains a polyglutamine (PolyQ) region, the expansion of which causes spinocerebellar ataxia type-3

academic.oup.com
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Lorenza Penengo Lab retweeted
Doksani Lab@DoksaniLab
24 Mar 2023
A new substrate for Telomerase? By visualizing telomerase activity on telomeric replication forks we provide strong evidence in support of a hypothesis that has been lingering for a while in the field. @ScienceAdvances @luchenlab_FCCC science.org/doi/10.1126/scia…

The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats

Fork collapse during replication of telomeric repeats generates 3'-DNA ends that are elongated by telomerase.

science.org
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After first showing some of these new, exciting data from the lab @CSHL Replication 2021, we now share a full story on the impact of IFN signaling and ISG15 on replication fork integrity, proliferation and chemoresistance in BRCA-deficient cells biorxiv.org/content/10.1101/… Please RT!

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process...

biorxiv.org
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Great collaborative effort with Shyam Sharan and @Arnab_RC1. Thrilled to hear opinions and suggestions!
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Important follow-up of the first link between ISG15 and replication fork progression that we reported in 2020 pubmed.ncbi.nlm.nih.gov/3259…

Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal...

DNA replication is highly regulated by the ubiquitin system, which plays key roles upon stress. The ubiquitin-like modifier ISG15 (interferon-stimulated gene 15) is induced by interferons, bacterial...

pubmed.ncbi.nlm.nih.gov
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Excited about the next speaker at our Monday Seminar (MoSe) series!!
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