Our newest paper is out today in Nature showing how sensitive children’s immune responses are to bias from past immunity.
news.weill.cornell.edu/news/…
nature.com/articles/s41586-0…
Congratulations and completely expected to @victora_lab for becoming an HHMI investigator
hhmi.org/news/hhmi-invests-o…
PatWilsonLab retweeted
Gut of newborns has unique bacteria that produce serotonin and promote the development of immune cells that may prevent allergic reactions to food and beneficial gut microbes, according to a preclinical study from @WCMpeds.
bit.ly/3PjJDhi
Great job Josh! This was a "hunch" project that turned out to be so interesting once Josh dug in.
In a nutshell: How do you balance the need for maximum antibody diversity and adaptability with the requirement for maintaining the ability of an antibody to express well?
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This is an amazing and intuitive approach as @stutangye has done so well for decades
PatWilsonLab retweeted
Most recent work from the lab just out @Nature. By combining ancient DNA work, population genomics, and in vitro infections we show that the Black Death shaped the evolution of immune genes. Kuddos to co-first authors @TaurVil and Jennifer Klunk. nature.com/articles/s41586-0…
PatWilsonLab retweeted
A curated set of human immunoglobulin germline genes/alleles for better annotation of sequences encoding antibodies and antibody repertoires. It has potential to solve annotation problems you have not been aware of! #antibody #AIRRseq #repertoire
biorxiv.org/content/10.1101/…
PatWilsonLab retweeted
Antibodies are the product of evolution on two timescales: over millions of years in vertebrate populations, and within weeks of infection or 💉 in populations of B cells. We ask how those timescales interact in our paper out in @PLOSPathogens 🧵 1/n t.ly/U84Un
PatWilsonLab retweeted
2/ Hi friends - please RT the following 2 ads. We are looking for talented people to join our HI3 team. Help us prepare for future pandemics jobs.utoronto.ca/job/Toronto…
PatWilsonLab retweeted
1/ Hi friends - please RT the following 2 ads. We are looking for talented people to join our HI3 team. Help us prepare for future pandemics! jobs.utoronto.ca/job/Toronto…
Many thanks to the thoughtful and comprehensive commentary from @ShivPillai4 on our paper led by @SirirukCh about broadly protective mAbs against SARS-CoV-2, both out today in the JCI:
Comment:jci.org/articles/view/168080
Paper:jci.org/articles/view/166844
What a cool paper. I wonder if there are any active mutator mechanisms involved, analogous to AID in B cells.
Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9… 1/10
Great to see you hanging out behind my apartment! Haha lets grab lunch or dinner or at least a beer:
[email protected] – at Queens, NY
Check out our new paper led by @SirirukCh in collaboration with @HalfmannPeter from Yoshi Kawaoka's lab and Hejun Liu from Ina Wilson's lab describing a broadly cross reactive mAb to all SARS-CoV-2 variants. Overview:news.weill.cornell.edu/news/… paper: jci.org/articles/view/166844…
Congrats Florian!
In case you missed it, Dr. Florian Krammer (@florian_krammer), co-PI of SEM CIVIC, was recently elected to the American Academy of Microbiology for his achievements in vaccinology and influenza biology! Check out our CIVICs News post to learn more: ow.ly/Y8w550NyUlu
PatWilsonLab retweeted
Celebrating the new boss, @SesmaLab ! With @VivianaSimonLab @jeanklim @mschotsaert and many others from our department. Cheers to Ana and to a bright future for Mount Sinai Microbiology!
Thanks to Daniel Caughey for organizing this!
PatWilsonLab retweeted
Thanks Florian and Viviana for organizing it! I could not be happier about the opportunity to lead this AMAZING department! Feeling supported by this great group of colleagues is wonderful 🥰. Taking the torch from the great Peter Palese and carrying it forward! #SinaiMicro
Celebrating the new boss, @SesmaLab ! With @VivianaSimonLab @jeanklim @mschotsaert and many others from our department. Cheers to Ana and to a bright future for Mount Sinai Microbiology!
Thanks to Daniel Caughey for organizing this!