Training human brain cells for compute (YC S26)

Joined May 2026
Parasma retweeted
A glimpse into the future!
This week’s Paper Club is all about alternative compute. Modern AI has been shaped by a tight coupling between transformers, backpropagation, and GPUs. But as compute efficiency starts to plateau, there may be very different ways to build the machines that come next. We explore what AI compute could look like beyond conventional digital hardware through optical systems that use light to perform computation, neuromorphic architectures inspired by the brain, and experiments teaching living brain cells to play Doom. 00:07 — @FrancoisChauba1: Why Alternative Compute? 03:38 — Beyond Backpropagation 08:08 — Zero-Order Optimization and SOMA 15:06 — Ilker Oguz: Computing With Light 19:27 — Why Optical Computing Isn’t Everywhere Yet 22:23 — Building a Diffusion Model With Light 30:03 — Optical Computing Q&A 39:00 — @AlokVasudev: What Is Neuromorphic Computing? 45:23 — What the Brain Can Teach Us About Chips 49:35 — Where Neuromorphic Computing Stands Today 54:24 — Neuromorphic Computing Q&A 1:04:24 — @vytalow: Teaching Brain Cells to Play Doom 1:07:48 — Training Biological Neurons With Reinforcement Learning 1:12:28 — How Brain Cells Learn From Feedback 1:15:40 — Biological Computing Q&A
1
4
40
9,769
Parasma retweeted
Parasma Founder & CEO @vytalow, who previously went viral for training human brain cells to play Doom, says that using them for compute could be far more energy-efficient than today's silicon chips. "Regardless of how efficient we make silicon, we still haven't solved the efficiency aspect of it, in terms of power efficiency." "I think human brains are extremely power efficient in comparison to silicon." "There are things that we can harness [with human brain cells] on top of other stuff like sample efficiency and continual learning."
9
13
3
87
44,286
Parasma retweeted
Introducing Parasma. Previously, we trained human brain cells to play Doom. Now, we trained them to predict words in a sentence. We are unlocking human brain cells for compute. Learn more here: parasma.com/news/human-brain… @ParasmaAI
81
40
43
617
2,287,870
Parasma retweeted
hiring an intern @ParasmaAI - provably brilliant at information theory - strong at RL - excited about training brain cells if ur a furry, neurodivergent, or have something unique to add please apply point form, 60 words max, email careers [at] parasma [dot] com
17
3
94
17,556
Parasma retweeted
Training human brain cells for compute got me into the @ycombinator S26 batch! Solve really hard problems and change the world I am also looking to grow the team, if you love RL leave a comment and DM me so I see it!
39
4
2
135
62,721
Parasma retweeted
Could we write intelligence to brains quicker than a human could learn it using external optimization methods? I went on @LBC to talk about brain cells, Doom, and some of the work we are doing at @ParasmaAI !
6
3
26
2,954