@OusalemF

Détermination

 Paris
Joined August 2020
  • Tweets136
  • Following70
  • Followers37
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REGULATION OF COLONIC MACROPHAGES AND TYPE-17 AND REGULATORY T CELLS IN DSS-COLITIS BY IBD-ASSOCIATED TRANSCRIPTION FACTOR, CREM biorxiv.org/content/10.64898… #biorxiv_immuno
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Careful selection of Cas13 variants and delivery methods minimizes collateral RNA degradation go.nature.com/4gEn95x rdcu.be/eZ8CF

Precise RNA targeting with CRISPR–Cas13d

Nature Biotechnology - Careful selection of Cas13 variants and delivery methods minimizes collateral RNA degradation.

nature.com
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Congratulations to Luce on your PhD paper! I’m very happy to be a co-author of this wonderful work. Congratulations to all the authors — the best is yet to come for us very soon. biorxiv.org/content/10.64898…
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Ousalem Farès retweeted
Sharma Lab@SharmaLab11 Apr 2025
We are happy to share our new paper on the #Campylobacter translatome and #smallproteins out now in @NatureComms. Many congrats to @KathiFroschauer & @campy_bara and all collaboration partners! @SPP__2002 nature.com/articles/s41467-0…

Complementary Ribo-seq approaches map the translatome and provide a small protein census in the...

Nature Communications - Bacterial genomes still contain many hidden and uncharacterized genes. Using complementary Ribo-seq approaches, Froschauer, Svensson et al. here annotate start and stop...

nature.com
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nature
@Nature26 Mar 2025
Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome go.nature.com/3FJLuu0
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Olivier Duss@OlivierDuss4 Dec 2024
First paper of our lab today @Nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl doi.org/10.1038/s41586-024-0…

Tracking transcription–translation coupling in real time

Nature - Single-molecule fluorescence microscopy experiments with a recombinant Escherichia coli transcription–translation system provides insights into the coordination of the transcription...

nature.com
Olivier Duss@OlivierDuss14 Dec 2023
Our new findings on how the ribosome couples with the RNA polymerase are summarized in a movie highlighting the dynamics of the process🎞️🎥 Thanks to Clemens Bretscher for the great animations! - behance.net/cbretscher @embl paper in @biorxivpreprint biorxiv.org/content/10.1101/…
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The paper is finally out in @NAR_Open ! doi.org/10.1093/nar/gkae1131 - We demonstrate that bacterial sRNA terminators get involved in really strong and specific gene expression regulation. Congrats to co-first author @_Eugenisimo and colleagues in Maude Guillier's lab @EgmIbpc
Dr Jonathan Jagodnik@JagodnikScience23 Jan 2024
New year, new preprint! A great pleasure to share our story of fepA repression by multiple small RNAs, with the unexpected implication of sRNA terminator loops! Great job from coworkers in Maude Guillier's lab, @_Eugenisimo , Alexey and Fanny. Summary will come with final version
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A CRISPR screen targeting RNA identifies essential lncRNAs in human cells, revealing lncRNAs whose expression correlates with the survival of tumors, identifying new biomarkers and potential targets for therapeutics cell.com/cell/fulltext/S0092… #NBThighlight

RETRACTED: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells

This article has been retracted: please see Elsevier policy on Article Withdrawal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal).This article has been retracted at the...

cell.com
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Green Lab@GreenLabJHMI13 Nov 2024
Excited to see our LARP1 manuscript published at The EMBO Journal. We show that LARP1 directly binds non-translating ribosomes and TOP mRNAs. An excellent collaboration with the @jingdongcheng lab! embopress.org/doi/full/10.10…
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An engineered E. coli optimizes production and delivery of neoepitope-containing peptide arrays, driving a potent T-cell mediated anticancer response that eliminates aggressive solid tumor growth in mice nature.com/articles/s41586-0… #NBThighlight

Probiotic neoantigen delivery vectors for precision cancer immunotherapy

Nature - Probiotic Escherichia coli Nissle 1917 is engineered as an antitumour vaccination platform optimized for enhanced production and cytosolic delivery of neoepitope-containing peptide arrays...

nature.com
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Global profiling of protein complex dynamics with an experimental library of protein interaction markers go.nature.com/4dQabQw
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WilsonLab@WilsonLab217 Oct 2024
Paenilamicins represent a promising new class of antibiotics : MIN Faculty : University of Hamburg min.uni-hamburg.de/en/ueber-…

Paenilamicins represent a promising new class of antibiotics

min.uni-hamburg.de
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A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy go.nature.com/4eEVVvo
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Escherichia coli engineered to display cytokines destroy hard-to-treat tumors by boosting the activity of local native and adoptive immune effector cells #NBTNV go.nature.com/3XRyVSv rdcu.be/dWuJ3

Bacteria displaying cytokines heat up the tumor microenvironment

Nature Biotechnology - Escherichia coli engineered to display cytokines destroy hard-to-treat tumors by boosting the activity of local native and adoptive immune effector cells.

nature.com
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The Nobel Prize
@NobelPrize9 Oct 2024
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Vasili Hauryliuk@hauryliuk10 Sep 2024
biorxiv.org/content/10.1101/…

Novel RNA-binding protein YebC enhances translation of proline-rich amino acid stretches in bacteria

The ribosome employs a set of highly conserved translation factors to efficiently synthesise proteins. Some translation factors interact with the ribosome in a transient manner and are thus challen...

biorxiv.org
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biorxiv.org/content/10.1101/…

CodonTransformer: a multispecies codon optimizer using context-aware neural networks

The genetic code is degenerate allowing a multitude of possible DNA sequences to encode the same protein. This degeneracy impacts the efficiency of heterologous protein production due to the codon...

biorxiv.org
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I am pleased to share my work on Global regulation via modulation of ribosome pausing by the ABC-F protein EttA, which I carried out in @BoelLab laboratory. Congratulations to all the authors. nature.com/articles/s41467-0…

Global regulation via modulation of ribosome pausing by the ABC-F protein EttA

Nature Communications - The physiological function of the ABC-F translation factor has remained elusive. Here, the authors show that one of them, EttA, regulates the translation of mRNAs encoding...

nature.com
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The human mitochondrial translation factor TACO1 alleviates mitoribosome stalling at polyproline stretches - PubMed pubmed.ncbi.nlm.nih.gov/3903…

The human mitochondrial translation factor TACO1 alleviates mitoribosome stalling at polyproline...

The prokaryotic translation elongation factor P (EF-P) and the eukaryotic/archaeal counterparts eIF5A/aIF5A are proteins that serve a crucial role in mitigating ribosomal stalling during the transl...

pubmed.ncbi.nlm.nih.gov
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CNRS Alsace@CNRS_Alsace4 Jun 2024
Toutes nos félicitations ! 👏👏👏
Académie des sciences@AcadSciences4 Jun 2024
🔴 EN DIRECT | Cérémonie de réception des nouveaux membres 🌿« STRUCTURE DES RIBOSOMES » Marat YUSUPOV, Directeur de recherche au @CNRS, Institut de génétique et de biologie moléculaire et cellulaire, section de #BiologieMoléculaireCellulaireGénomique 👉 youtube.com/live/ChRvAxZ8WVY
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