@OhataLab
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Protein Chemistry Research Group @NCState
Raleigh, NC
Joined May 2020
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Want to improve your writing at a word level? Try the CASPArS method! It's free!
This method visualizes how and how often a word of interest is used in a certain context.
Virtually applicable for any given science field.
doi.org/10.1021/acs.jchemed.…
Somebody told you not to put enzymes in nonaqueous conditions? Our opinion paper described the "wild" approaches of nonaqueous enzymology for various purposes related to pharma, food, energy, etc. Part of special issue Biocatalysis and Biotransformation
sciencedirect.com/science/ar…
Submit your paper to the latest special issue of
@BioconjChem, "Targeted Protein and Nucleic Acid Degradation: From Molecular Design to Therapeutic Translation"!
axial.acs.org/biological-che…
Jun is now an Early Career Board member of the @BioconjChem journal! If you have any ideas to make the bioconjugation and relevant fields better, feel free to reach out to him!!
axial.acs.org/biological-che…
When there was a challenge to reproduce mechanochemistry experiments to make a dehydroalanine peptide, we found liquid-assisted grinding helps obtain the product more reliably for this particular case! Published in @OrgBiomolChem doi.org/10.1039/D6OB00662K
By borrowing awesome mechanochemical Birch reduction of Profs. Kubota and @haj19932469, we tried chemical modification of phenylalanine in peptides! Diels-Alder reaction to potentially label the reduced aromatic ring. @JOC_OL doi.org/10.1021/acs.joc.5c02…
Diketopiperazines are peptides and also heterocycles like nucleobases. They often show up in prebiotic chemistry research, but are they really important? Check out a review from our group @AsianJOrgChem
dx.doi.org/10.1002/ajoc.7039…
Ohata Lab retweeted
Holy electrophilic amine 🤯!!! Excited to have my *first* first-author paper live in ACS Cat today. I can’t wait to see what our lab and others continue to do with N-halamines!
KFB Lab Alert: Our first efforts in biocatalytic chlorination of aliphatic amines is now online @ACSCatalysis! Huge congratulations to @EJGChem, @sp3intermediate, Sophie, @Logan_Zane97, and John!
pubs.acs.org/doi/10.1021/acs…
It may sound weird but recent bioconjugation methods often rely on a gas... Check out our collaborative review with @BallResearch. Published @ChemEurJ
doi.org/10.1002/chem.2025035…
A classical Friedel-Crafts reaction may not be biocompatible partly because acid catalysts are needed. Our work @JACS_Au showed a boron unit makes it "catalyst-free" for tryptophan bioconjugation! The century-old reaction still has a lot going on!
doi.org/10.1021/jacsau.5c011…
A cyclic peptide found in meteorite may undergo mechanochemical reactions with formaldehyde! The first prebiotic chemistry paper from our group published in ACS Bio&Med Chem Au. doi.org/10.1021/acsbiomedche…
Our writing method CASPArS is available in Japanese now! We thank @chemstation to make this happen. Hope this will be helpful for Japanese learners. Original article: pubs.acs.org/doi/10.1021/acs…
Our collaborative review paper with the @K_Oisaki & Sato labs about catalysis of protein bioconjugation was published @ChemCatChem
See how 7 types of catalysis were used for modification of proteins!
doi.org/10.1002/cctc.2024021…
Serine has diverse roles in living systems, but development of serine labeling tools has been a challenge. Our work published @ChemEurJ achieved chemoselective serine acylation in an unbiased manner!
doi.org/10.1002/chem.2024040…
The beginning of a professor job can be difficult. Fortunately for Jun, Laura (laura4acs.org) has been in the same department, providing great support and wisdom. You wouldn’t regret voting for her for the ACS president! (Please repost this to support her if possible!)
Our metal-free tryptophan labeling paper by @NuruzzamanNibir and @bcolella219 is published in @rsc_chembio
as part of the Emerging Investigators collection!
Cell lysate modification in HFIP was compared with aqueous lysine and cysteine modification.
doi.org/10.1039/D4CB00142G
Many bioconjugation methods started using fluoroalcohols TFE and HFIP. Check out our review by @NuruzzamanNibir @ZeinabNizam published in @TetrahedronChem as part of their special issue "Biomolecule Synthesis and Modification".
doi.org/10.1016/j.tchem.2024…
Ohata Lab retweeted
KFB Lab Alert: Congratulations to @EJGChem on her News & Views Article @NatureSynthesis covering a pair of fantastic reports on a new biocatalytic strategy for radical fluorination by @pengliu_group, @yang2biocat, Yunfang Yang, @MarcGBQ, @xiongyih!
Now online:
News & Views on the Articles by @pengliu_group @yang2biocat Yunfang Yang @MarcGBQ @xiongyih
nature.com/articles/s44160-0… ($)
nature.com/articles/s44160-0… ($)
A radical development for enzymatic fluorination by @EJGChem & @KFBChem @EmoryChem
nature.com/articles/s44160-0… ($)
Ohata Lab retweeted
New JCE ASAP article! We surveyed industry chemists from 80 companies about the undergraduate instrumentation experience / skill development that best prepared them for chemical industry.
Happy first pub day to @DavidTHamilton and Alyssa Castillo!
pubs.acs.org/doi/10.1021/acs…
